Details of Disease

General Information of Disease (ID: DISKAXY9)

Disease Name	Cluster headache
Synonyms	headaches, cluster; cluster headaches, episodic; episodic cluster headaches; cluster headaches, chronic; cluster headache, episodic; cluster headache, chronic; episodic cluster headache; syndrome, Horton's; neuralgia, ciliary; headaches, episodic cluster; headaches, chronic cluster; syndrome, Horton; headache syndromes, cluster; headache, chronic cluster; cluster headaches, atypical; atypical cluster headache; chronic cluster headaches; headache, episodic cluster; cluster headache syndromes; neuralgic migraine; headache syndrome, cluster; atypical cluster headaches; cluster headaches; headache, cluster; cluster headache, atypical; syndrome, cluster headache; chronic cluster headache; neuralgic migraines; vasomotor headache; headache, atypical cluster; syndromes, cluster headache; headaches, atypical cluster; beuralgias, ciliary; cluster migraine; histamine headache; Horton's neuralgia; histamine cephalgias; erythroprosopalgia of bing; Cephalgia, histamine; ciliary neuralgias; Hortons syndrome; erythromelalgia of the head; cluster headache syndrome; Horton's headache; Horton's syndrome; ciliary neuralgia; migraines, neuralgic; migraine, neuralgic; Cephalgias, histamine; histamine cephalgia; migrainous neuralgia; Horton syndrome; cluster headache; red migraine; Horton headache
Disease Class	8A81: Tension-type headache
Definition	A headache disorder that is characterized by periodic severe, unilateral orbital, supraorbital, and/or temporal pain, and is associated with ipsilateral cranial autonomic symptoms.
Disease Hierarchy	DISMBYHZ: Trigeminal autonomic cephalalgia DIS6ZC3X: Brain disease DISKAXY9: Cluster headache
ICD Code	ICD-11 ICD-11: 8A81.0 ICD-10 ICD-10: G44.0 Expand ICD-11 '8A81.0 Expand ICD-10 'G44.0
Disease Identifiers	MONDO ID MONDO_0043537 MESH ID D003027 UMLS CUI C0009088 MedGen ID 3503 HPO ID HP:0012199 SNOMED CT ID 193031009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 5 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Caffeine	DMKBJWP	Approved	Small molecular drug	[1]
Dihydroergotamine	DM5IKUF	Approved	Small molecular drug	[2]
Ergotamine	DMKR3C5	Approved	Small molecular drug	[3]
Phenobarbital	DMXZOCG	Approved	Small molecular drug	[4]
Sumatriptan	DMVYXR8	Approved	Small molecular drug	[5]
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This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PF-05280586	DMNZOCK	Phase 3	NA	[6]
Telcagepant	DMFT5D6	Phase 2	Small molecular drug	[7]
BF-1	DM7RPSG	Phase 1	Small molecular drug	[8]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ALGRX 2872	DM9Y5M5	Investigative	NA	[9]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADCYAP1	TTW4LYC	Limited	Biomarker	[10]
CACNA1A	TTX4QDJ	Limited	Biomarker	[11]
S100A12	TTQ4ESF	moderate	Biomarker	[12]
CALCA	TTVSFJW	Strong	Genetic Variation	[10]
HCRT	TTU5HJP	Strong	Genetic Variation	[13]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ADH4	DEOCWU3	Limited	Genetic Variation	[14]
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This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CLOCK	OTNEOJY7	Strong	Genetic Variation	[15]
NRXN3	OTJ0I7HJ	Strong	Genetic Variation	[16]
RBM3	OTAJ7R31	Strong	Biomarker	[17]
TRAF3IP2	OTLLZERL	Strong	Biomarker	[18]
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References

1	Caffeine FDA Label
2	Dihydroergotamine FDA Label
3	Ergotamine FDA Label
4	Phenobarbital FDA Label
5	Sumatriptan FDA Label
6	ClinicalTrials.gov (NCT02213263) A Study Of PF-05280586 (Rituximab-Pfizer) Or MabThera (Rituximab-EU) For The First-Line Treatment Of Patients With CD20-Positive, Low Tumor Burden, Follicular Lymphoma (REFLECTIONS B328-06). U.S. National Institutes of Health.
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 703).
8	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8424).
9	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
10	Calcitonin-gene related peptide and disease activity in cluster headache.Cephalalgia. 2019 Apr;39(5):575-584. doi: 10.1177/0333102419837154. Epub 2019 Mar 9.
11	No involvement of the calcium channel gene (CACNA1A) in a family with cluster headache.Cephalalgia. 2001 Dec;21(10):959-62. doi: 10.1046/j.1468-2982.2001.00283.x.
12	Treatment of the Patient with Refractory Headache.Curr Pain Headache Rep. 2018 Mar 19;22(4):23. doi: 10.1007/s11916-018-0677-5.
13	Linking Cigarette Smoking/Tobacco Exposure and Cluster Headache: A Pathogenesis Theory.Headache. 2018 Jul;58(7):1096-1112. doi: 10.1111/head.13338. Epub 2018 Jul 16.
14	Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.J Mol Neurosci. 2020 Mar;70(3):467-474. doi: 10.1007/s12031-019-01439-0. Epub 2019 Nov 25.
15	Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study.J Headache Pain. 2018 Jan 9;19(1):1. doi: 10.1186/s10194-017-0831-1.
16	Molecular analysis of cluster headache.Clin J Pain. 2015 Jan;31(1):52-7. doi: 10.1097/AJP.0000000000000075.
17	Preliminary Transcriptome Analysis in Lymphoblasts from Cluster Headache and Bipolar Disorder Patients Implicates Dysregulation of Circadian and Serotonergic Genes.J Mol Neurosci. 2015 Jul;56(3):688-95. doi: 10.1007/s12031-015-0567-9. Epub 2015 Apr 28.
18	Differential efficacy of non-invasive vagus nerve stimulation for the acute treatment of episodic and chronic cluster headache: A meta-analysis.Cephalalgia. 2019 Jul;39(8):967-977. doi: 10.1177/0333102419856607. Epub 2019 Jun 10.