Details of Disease

General Information of Disease (ID: DISKOGZP)

• Disease Name: Corneal neovascularization
• Disease Class: 9A76-9A78: Corneal disease
• Definition: New blood vessels originating from the corneal veins and extending from the limbus into the adjacent corneal stroma. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as trachoma, viral interstitial keratitis, microbial keratoconjunctivitis, and the immune response elicited by corneal transplantation.
• Disease Hierarchy:
  DISMFOEI: Keratitis
  DISKOGZP: Corneal neovascularization
• ICD Code: ICD-11: ICD-11: 9A78
• Disease Identifiers:
  MONDO ID: MONDO_0006713
  MESH ID: D016510
  UMLS CUI: C0085109
  MedGen ID: 43103
  HPO ID: HP:0011496
  SNOMED CT ID: 246925003

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Patented Agent(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Antibodie derivative 9	DMDRJ31	Patented	Antibody	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
VEGFA	TT3LJ9K	moderate	Biomarker	[2]
ARF1	TT70KXY	Strong	Biomarker	[3]
FGF2	TTGKIED	Strong	Altered Expression	[4]
FLT1	TT1VAUK	Strong	Biomarker	[5]
ITGAV	TTT1R2L	Strong	Biomarker	[6]
LYVE1	TTG8DNU	Strong	Biomarker	[7]

This Disease Is Related to 15 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ADAMTS9	OTV3Q0DS	Strong	Biomarker	[8]
ANGPT4	OT881M3K	Strong	Biomarker	[9]
ANGPTL1	OTXIN6V5	Strong	Biomarker	[9]
ECM1	OT1K65VW	Strong	Altered Expression	[10]
IL1F10	OTJAASGC	Strong	Biomarker	[11]
KRT13	OTTYSKGX	Strong	Altered Expression	[12]
KRT3	OT5U1Y8L	Strong	Altered Expression	[12]
MUC4	OTLT11V1	Strong	Biomarker	[13]
MXRA7	OTVQLYIY	Strong	Altered Expression	[10]
NRF1	OTOXWNV8	Strong	Altered Expression	[14]
NTN4	OTDRRMP3	Strong	Altered Expression	[15]
PROX1	OT68R6IO	Strong	Biomarker	[16]
SEMA3F	OTQFMS8S	Strong	Biomarker	[17]
TRAM1	OT3I0H8E	Strong	Biomarker	[18]
EMP2	OTPS2H0L	Definitive	Biomarker	[19]

References

• [1] VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004.
• [2] lncRNA MIAT suppression alleviates corneal angiogenesis through regulating miR-1246/ACE.Cell Cycle. 2019 Mar-Apr;18(6-7):661-669. doi: 10.1080/15384101.2019.1578143. Epub 2019 Mar 5.
• [3] ADP-ribosylation factor as a novel target for corneal neovascularization regression.Mol Vis. 2012;18:2947-53. Epub 2012 Dec 12.
• [4] B-cell leukemia/lymphoma 10 promotes angiogenesis in an experimental corneal neovascularization model.Eye (Lond). 2018 Jul;32(7):1220-1231. doi: 10.1038/s41433-018-0039-x. Epub 2018 Mar 8.
• [5] MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells.Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2321-2329. doi: 10.1167/iovs.18-26277.
• [6] Inhibition of corneal neovascularization by alpha(v)-integrin antagonists in the rat.Graefes Arch Clin Exp Ophthalmol. 2000 Jan;238(1):88-93. doi: 10.1007/s004170050015.
• [7] Corneal Neovascularization: A Combined Approach of Bevacizumab and Suramin Showed Increased Antiangiogenic Effect Through Downregulation of BFGF and P(2)X(2).Curr Eye Res. 2018 Apr;43(4):466-473. doi: 10.1080/02713683.2017.1416146. Epub 2017 Dec 21.
• [8] ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells.Am J Pathol. 2010 Mar;176(3):1494-504. doi: 10.2353/ajpath.2010.090655. Epub 2010 Jan 21.
• [9] Biological characterization of angiopoietin-3 and angiopoietin-4.FASEB J. 2004 Aug;18(11):1200-8. doi: 10.1096/fj.03-1466com.
• [10] Public data mining plus domestic experimental study defined involvement of the old-yet-uncharacterized gene matrix-remodeling associated 7 (MXRA7) in physiopathology of the eye.Gene. 2017 Oct 20;632:43-49. doi: 10.1016/j.gene.2017.08.018. Epub 2017 Aug 26.
• [11] The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization.Curr Mol Med. 2019;19(8):589-596. doi: 10.2174/1566524019666190627122655.
• [12] The Impact of Limbal Mesenchymal Stromal Cells on Healing of Acute Ocular Surface Wounds Is Improved by Pre-cultivation and Implantation in the Presence of Limbal Epithelial Cells.Cell Transplant. 2019 Sep-Oct;28(9-10):1257-1270. doi: 10.1177/0963689719858577. Epub 2019 Jun 17.
• [13] Muc4 expression during blood vessel formation in damaged rat cornea.Curr Eye Res. 2006 Dec;31(12):1011-4. doi: 10.1080/02713680601052155.
• [14] Tetramethylpyrazine in a Murine Alkali-Burn Model Blocks NFB/NRF-1/CXCR4-Signaling-Induced Corneal Neovascularization.Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2133-2141. doi: 10.1167/iovs.17-23712.
• [15] Netrin-4 Mediates Corneal Hemangiogenesis but Not Lymphangiogenesis in the Mouse-Model of Suture-Induced Neovascularization.Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1387-1396. doi: 10.1167/iovs.16-19249.
• [16] Limited versus total epithelial debridement ocular surface injury: Live fluorescence imaging of hemangiogenesis and lymphangiogenesis in Prox1-GFP/Flk1::Myr-mCherry mice.Biochim Biophys Acta. 2016 Oct;1860(10):2148-56. doi: 10.1016/j.bbagen.2016.05.027. Epub 2016 May 24.
• [17] Semaphorin 3F Modulates Corneal Lymphangiogenesis and Promotes Corneal Graft Survival.Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):5277-5284. doi: 10.1167/iovs.18-24287.
• [18] Blockade of the intermediate-conductance Ca(2+)-activated K+ channel inhibits the angiogenesis induced by epidermal growth factor in the treatment of corneal alkali burn.Exp Eye Res. 2013 May;110:76-87. doi: 10.1016/j.exer.2013.02.015. Epub 2013 Mar 7.
• [19] Epithelial Membrane Protein-2 (EMP2) Antibody Blockade Reduces Corneal Neovascularization in an In Vivo Model.Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):245-254. doi: 10.1167/iovs.18-24345.