Details of Disease

General Information of Disease (ID: DISNZNTG)

Disease Name	Gastric disease
Synonyms	gastric disease; stomach disorder; stomach disease or disorder; stomach disease; gastropathy; disorder of stomach; disease or disorder of stomach; disease of stomach
Disease Class	DA40-DA7Z: Gastric disease
Definition	A disease involving the stomach.
Disease Hierarchy	DISWD40R: Disease DIS7JDYJ: Gastrointestinal disease DISNZNTG: Gastric disease
ICD Code	ICD-11 ICD-11: DA40-DA7Z
Disease Identifiers	MONDO ID MONDO_0004298 MESH ID D013272 UMLS CUI C0038354 MedGen ID 21329 SNOMED CT ID 29384001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SprayGel	DMNGQL2	Approved	NA	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 8 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ANXA1	TTUCK4B	Strong	Therapeutic	[2]
CALCA	TTVSFJW	Strong	Biomarker	[3]
FKBP10	TT4P8O2	Strong	Biomarker	[4]
FKBP1A	TTMW94E	Strong	Biomarker	[4]
FKBP7	TTO1ENI	Strong	Biomarker	[4]
GCG	TT6Y4PN	Strong	Therapeutic	[5]
HSD17B13	TTDJYZR	Strong	Altered Expression	[6]
MUC5AC	TTEL90S	Strong	Therapeutic	[7]
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⏷ Show the Full List of 8 DTT(s)

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
HSD17B7	DEDMWFX	Strong	Altered Expression	[6]
SMOX	DEOH5V3	Strong	Biomarker	[8]
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This Disease Is Related to 15 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DHRS11	OTU3J0ZL	Strong	Altered Expression	[6]
ERCC8	OT0T4WKI	Strong	Altered Expression	[9]
FKBP1B	OT8CMPB2	Strong	Biomarker	[4]
FKBP2	OTHBZHX0	Strong	Biomarker	[4]
FKBP3	OT7ETKPE	Strong	Biomarker	[4]
FKBP9	OTGRFVKZ	Strong	Biomarker	[4]
IL26	OT2WYCW4	Strong	Altered Expression	[10]
MIB2	OTJCC3HS	Strong	Genetic Variation	[11]
NKTR	OTIADJNW	Strong	Biomarker	[4]
PPIL1	OTS5S837	Strong	Biomarker	[4]
PPIL2	OTL9Y4IO	Strong	Biomarker	[4]
PPIL3	OT0GPU73	Strong	Biomarker	[4]
PPIL4	OTFTLFJS	Strong	Biomarker	[4]
PPIL6	OTOZQMQE	Strong	Biomarker	[4]
PPP1R12A	OT4AVU95	Strong	Biomarker	[12]
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⏷ Show the Full List of 15 DOT(s)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Annexin-1 is an endogenous gastroprotective factor against indomethacin-induced damage.Am J Physiol Gastrointest Liver Physiol. 2005 Mar;288(3):G481-6. doi: 10.1152/ajpgi.00299.2004. Epub 2004 Oct 7.
3	The protective effects of calcitonin gene-related peptide on gastric mucosa injury after cerebral ischemia reperfusion in rats.Regul Pept. 2010 Feb 25;160(1-3):121-8. doi: 10.1016/j.regpep.2009.11.008. Epub 2009 Nov 10.
4	Differential Proteomic Analysis Reveals Protein Networks and Pathways that May Contribute to Helicobacter pylori FKBP-Type PPIase-Associated Gastric Diseases.Proteomics Clin Appl. 2018 May;12(3):e1700127. doi: 10.1002/prca.201700127. Epub 2017 Dec 5.
5	Central effects of glucagon-like peptide-1 on cold-restraint stress-induced gastric mucosal lesions.Turk J Gastroenterol. 2007 Sep;18(3):150-6.
6	Sex steroid metabolism in human gastric mucosa: 17 beta-hydroxysteroid dehydrogenase type 2 in normal, inflamed and neoplastic gastric tissues.Anticancer Res. 2003 Sep-Oct;23(5A):3889-97.
7	Effect of Bifidobacterium bifidum BF-1 on gastric protection and mucin production in an acute gastric injury rat model.J Dairy Sci. 2013 Feb;96(2):832-7. doi: 10.3168/jds.2012-5950. Epub 2012 Nov 29.
8	Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases.Curr Top Microbiol Immunol. 2017;400:27-52. doi: 10.1007/978-3-319-50520-6_2.
9	Epistatic SNP interaction of ERCC6 with ERCC8 and their joint protein expression contribute to gastric cancer/atrophic gastritis risk.Oncotarget. 2017 Jun 27;8(26):43140-43152. doi: 10.18632/oncotarget.17814.
10	Investigation on correlations of serum IL-26 with diagnosis and staging of gastric cancer.J BUON. 2019 Jan-Feb;24(1):215-220.
11	MIB2 variants altering NOTCH signalling result in left ventricle hypertrabeculation/non-compaction and are associated with Mntrier-like gastropathy.Hum Mol Genet. 2017 Jan 1;26(1):33-43. doi: 10.1093/hmg/ddw365.
12	The mechanical binding strengths of Helicobacter pylori BabA and SabA adhesins using an adhesion binding assay-ELISA, and its clinical relevance in Japan.Microbiol Immunol. 2010 Aug;54(8):442-51. doi: 10.1111/j.1348-0421.2010.00237.x.