Details of Disease

General Information of Disease (ID: DISO5XCZ)

Disease Name Asbestosis
Synonyms
idiopathic interstitial pneumonitis - from asbestos exposure; asbestos intoxication; pulmonary fibrosis - from asbestos exposure; asbestos pneumoconiosis; asbestos dust pneumoconiosis; asbestosis; asbestos intoxination; pneumoconiosis from asbestos dust
Disease Class CA60: Pneumoconiosis
Definition A lung disorder caused by inhalation of asbestos fibers. It results in fibrosis of the lung parenchyma. Signs and symptoms include coughing, shortness of breath and chest pain.
Disease Hierarchy
DISSJLBN: Pneumoconiosis
DISO5XCZ: Asbestosis
ICD Code
ICD-11
ICD-11: CA60.2
ICD-10
ICD-10: J61
Expand ICD-11
'CA60.2
Expand ICD-10
'J61
Disease Identifiers
MONDO ID
MONDO_0016466
MESH ID
D001195
UMLS CUI
C0003949
MedGen ID
2462
Orphanet ID
2302
SNOMED CT ID
22607003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
DasKloster 0039-01 DMKWCVL Investigative NA [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 8 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
NLRP3 TT4EN8X Limited Biomarker [2]
SERPINA1 TTA7UJC moderate Biomarker [3]
ARG1 TT7ZQEV Strong Biomarker [4]
CFD TT8D13I Strong Biomarker [5]
HSPA5 TTW26OG Strong Biomarker [6]
SLC40A1 TT6Y1PG Strong Biomarker [7]
SPP1 TT8ME6I Strong Biomarker [8]
NOS2 TTF10I9 Definitive Biomarker [9]
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⏷ Show the Full List of 8 DTT(s)
This Disease Is Related to 1 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
GSTT1 DE3PKUG Limited Genetic Variation [10]
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This Disease Is Related to 6 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ATF6 OTAFHAVI Strong Biomarker [6]
DDIT3 OTI8YKKE Strong Biomarker [6]
LYPD4 OTYNO8BS Strong Biomarker [11]
PRDX1 OTZ3BEC4 Strong Biomarker [12]
PRDX2 OTLWCY9T Strong Biomarker [12]
TPM4 OTN4YLYR Strong Biomarker [12]
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⏷ Show the Full List of 6 DOT(s)

References

1 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2 Genes involved in innate immunity associated with asbestos-related fibrotic changes.Occup Environ Med. 2014 Jan;71(1):48-54. doi: 10.1136/oemed-2013-101555. Epub 2013 Oct 4.
3 Pi*S and Pi*Z alpha 1 antitrypsin polymorphism and the risk for asbestosis in occupational exposure to asbestos.Toxicol Lett. 2002 Nov 15;136(1):9-17. doi: 10.1016/s0378-4274(02)00283-7.
4 Cu,Zn-Superoxide Dismutase-Mediated Redox Regulation of Jumonji Domain Containing 3 Modulates Macrophage Polarization and Pulmonary Fibrosis.Am J Respir Cell Mol Biol. 2016 Jul;55(1):58-71. doi: 10.1165/rcmb.2015-0183OC.
5 Adipokine adipsin is associated with the degree of lung fibrosis in asbestos-exposed workers.Respir Med. 2012 Oct;106(10):1435-40. doi: 10.1016/j.rmed.2012.07.003. Epub 2012 Jul 24.
6 Asbestos-induced disruption of calcium homeostasis induces endoplasmic reticulum stress in macrophages.J Biol Chem. 2014 Nov 28;289(48):33391-403. doi: 10.1074/jbc.M114.579870. Epub 2014 Oct 16.
7 Iron and Iron-Related Proteins in Asbestosis.J Environ Pathol Toxicol Oncol. 2015;34(4):277-85. doi: 10.1615/jenvironpatholtoxicoloncol.2015013397.
8 Osteopontin modulates inflammation, mucin production, and gene expression signatures after inhalation of asbestos in a murine model of fibrosis.Am J Pathol. 2011 May;178(5):1975-85. doi: 10.1016/j.ajpath.2011.01.048.
9 Dual role of inducible nitric oxide synthase in acute asbestos-induced lung injury.Free Radic Biol Med. 2002 Aug 15;33(4):491-501. doi: 10.1016/s0891-5849(02)00844-4.
10 Glutathione S-transferases GSTM1 and GSTT1 polymorphisms and asbestosis.J Occup Environ Med. 2007 Jun;49(6):667-71. doi: 10.1097/JOM.0b013e318065b855.
11 Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy.Environ Health. 2019 Aug 7;18(1):71. doi: 10.1186/s12940-019-0510-6.
12 Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure.Lung Cancer. 2012 Aug;77(2):450-9. doi: 10.1016/j.lungcan.2012.03.024. Epub 2012 Apr 24.