Details of Disease

General Information of Disease (ID: DISOLUZ1)

• Disease Name: Conduct disorder
• Definition: A disorder diagnosed in childhood or adolescence age group characterized by aggressive behavior, deceitfulness, destruction of property or violation of rules that is persistent and repetitive, and within a one year period.
• Disease Hierarchy:
  DISLR2HH: Specific developmental disorder
  DISOLUZ1: Conduct disorder
• Disease Identifiers:
  MONDO ID: MONDO_0005352
  MESH ID: D019955
  UMLS CUI: C0149654
  MedGen ID: 56196
  SNOMED CT ID: 430909002

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AVPR1A	TT4TFGN	Limited	Biomarker	[1]
DRD5	TTS2PH3	Limited	Biomarker	[2]
OPRD1	TT27RFC	Limited	Biomarker	[3]
PDE10A	TTJW4LU	Limited	Genetic Variation	[4]
SLC6A3	TTVBI8W	Strong	Biomarker	[5]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
GLDC	DEIN8FB	Limited	Genetic Variation	[6]

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
C1QTNF7	OTN1IFTK	Limited	Genetic Variation	[4]
EFNA5	OTOH4DRR	Limited	Biomarker	[7]
FGD1	OTV3T64P	Limited	Genetic Variation	[8]
FOXK2	OTFXDZ3R	Limited	Biomarker	[9]
OXT	OT48M72Z	Limited	Genetic Variation	[10]
ROBO2	OTFJ9FQW	Limited	Genetic Variation	[11]
CAMK2A	OTJGX19T	Strong	Genetic Variation	[12]
OSR1	OTB19LEQ	Strong	Biomarker	[13]

References

• [1] Genetic influences on conduct disorder.Neurosci Biobehav Rev. 2018 Aug;91:91-101. doi: 10.1016/j.neubiorev.2016.06.034. Epub 2016 Jun 24.
• [2] Testing for gene x environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior.Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 5;147B(1):49-53. doi: 10.1002/ajmg.b.30571.
• [3] Psychopathology, Dissociation and Somatic Symptoms in Adolescents Who Were Exposed to Traumatic Experiences.Front Psychol. 2018 Dec 4;9:2390. doi: 10.3389/fpsyg.2018.02390. eCollection 2018.
• [4] Genome-wide association study of conduct disorder symptomatology.Mol Psychiatry. 2011 Aug;16(8):800-8. doi: 10.1038/mp.2010.73. Epub 2010 Jun 29.
• [5] Interactions between early parenting and a polymorphism of the child's dopamine transporter gene in predicting future child conduct disorder symptoms.J Abnorm Psychol. 2011 Feb;120(1):33-45. doi: 10.1037/a0021133.
• [6] Clinical and molecular delineation of duplication 9p24.3q21.11 in a patient with psychotic behavior.Gene. 2015 Apr 10;560(1):124-7. doi: 10.1016/j.gene.2015.02.010. Epub 2015 Feb 7.
• [7] Family factors and sampling approach differentially influence attention deficit/hyperactivity disorder subtypes.Mol Psychiatry. 2004 Mar;9(3):260-3. doi: 10.1038/sj.mp.4001406.
• [8] Should childhood conduct disorder be necessary to diagnose antisocial personality disorder in adults?.Ann Clin Psychiatry. 2019 Feb;31(1):36-44.
• [9] Altered White-Matter Microstructure in Conduct Disorder Is Specifically Associated with Elevated Callous-Unemotional Traits.J Abnorm Child Psychol. 2018 Oct;46(7):1451-1466. doi: 10.1007/s10802-017-0375-5.
• [10] Variation in the Oxytocin Receptor Gene Is Associated With Social Cognition and ADHD.J Atten Disord. 2019 May;23(7):702-711. doi: 10.1177/1087054717706757. Epub 2017 May 6.
• [11] Replication of a ROBO2 polymorphism associated with conduct problems but not psychopathic tendencies in children.Psychiatr Genet. 2013 Dec;23(6):251-4. doi: 10.1097/YPG.0b013e3283650f83.
• [12] Association of ADAM10 and CAMK2A polymorphisms with conduct disorder: evidence from family-based studies.J Abnorm Child Psychol. 2011 Aug;39(6):773-82. doi: 10.1007/s10802-011-9524-4.
• [13] The role of effortful control in the development of ADHD, ODD, and CD symptoms.J Pers Soc Psychol. 2020 Jun;118(6):1226-1246. doi: 10.1037/pspp0000243. Epub 2019 Mar 28.