Details of Disease

General Information of Disease (ID: DISPU3H9)

• Disease Name: Plasmodium vivax malaria
• Synonyms: malaria by Plasmodium vivax; vivax malaria
• Disease Class: 1F40-1F45: Malaria
• Definition: Malaria resulting from infection by Plasmodium vivax.
• Disease Hierarchy:
  DISQ9Y50: Malaria
  DISPU3H9: Plasmodium vivax malaria
• ICD Code: ICD-11: ICD-11: 1F41
• Disease Identifiers:
  MONDO ID: MONDO_0005921
  MESH ID: D016780
  UMLS CUI: C0024537
  MedGen ID: 6186
  SNOMED CT ID: 27052006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Tafenoquine	DM1XT4N	Approved	Small molecular drug	[1]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Plasmodium vivax vaccine	DM3DF9G	Phase 1/2	NA	[2]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
IMX-MSP4	DMU74WJ	Investigative	NA	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ACKR1	TTKY2NS	Strong	Biomarker	[4]
CYP2D6	TTVG215	Strong	Genetic Variation	[5]
G6PD	TTKN8W0	Strong	Biomarker	[6]
SLCO1A2	TTUGD21	Strong	Genetic Variation	[7]
SLCO2B1	TTDL3UZ	Strong	Genetic Variation	[7]

This Disease Is Related to 9 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
COIL	OTP4I4DL	Strong	Biomarker	[8]
COQ2	OTDAKEY4	Strong	Biomarker	[9]
DDX39B	OTEVCFVU	Strong	Biomarker	[10]
DNAJC5	OTCZDXAL	Strong	Biomarker	[11]
FYB1	OT6345CH	Strong	Genetic Variation	[12]
GYPC	OTOEDR7O	Strong	Biomarker	[13]
MLC1	OTCNZLSP	Strong	Biomarker	[14]
TOLLIP	OTYEO4NR	Strong	Genetic Variation	[15]
ATAD1	OTJ02XFL	Definitive	Biomarker	[11]

References

• [1] Tafenoquine: First Global Approval.Drugs. 2018 Sep;78(14):1517-1523.
• [2] ClinicalTrials.gov (NCT01157897) Study of VMP001 and AS01B in Healthy Malaria-Naive Adults. U.S. National Institutes of Health.
• [3] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [4] Neutrophil counts in persons of African origin.Curr Opin Hematol. 2014 Jan;21(1):50-7. doi: 10.1097/MOH.0000000000000007.
• [5] Multiple relapses of Plasmodium vivax malaria acquired from West Africa and association with poor metabolizer CYP2D6 variant: a case report.BMC Infect Dis. 2019 Aug 9;19(1):704. doi: 10.1186/s12879-019-4357-9.
• [6] Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia.Malar J. 2019 Apr 2;18(1):111. doi: 10.1186/s12936-019-2745-7.
• [7] SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria.Pharmacogenomics. 2017 Oct;18(15):1393-1400. doi: 10.2217/pgs-2017-0077. Epub 2017 Oct 4.
• [8] Natural immune response to Plasmodium vivax alpha-helical coiled coil protein motifs and its association with the risk of P. vivax malaria.PLoS One. 2017 Jun 26;12(6):e0179863. doi: 10.1371/journal.pone.0179863. eCollection 2017.
• [9] Soluble recombinant merozoite surface antigen-142kDa of Plasmodium vivax: An improved diagnostic antigen for vivax malaria.J Microbiol Methods. 2016 Apr;123:44-50. doi: 10.1016/j.mimet.2016.02.003. Epub 2016 Feb 3.
• [10] DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outcomes of patients with Plasmodium vivax malaria.Malar J. 2014 Jul 19;13:278. doi: 10.1186/1475-2875-13-278.
• [11] Study of the genetic discrimination between imported and autochthonous cases of malaria in South Korea.J Travel Med. 2011 Jan-Feb;18(1):63-6. doi: 10.1111/j.1708-8305.2010.00473.x. Epub 2010 Dec 16.
• [12] Duffy blood group genotypes among malaria Plasmodium vivax patients of Baoulch population in Southeastern Iran.Asian Pac J Trop Med. 2014 Mar;7(3):206-7. doi: 10.1016/S1995-7645(14)60021-3.
• [13] Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes.Blood. 2014 May 1;123(18):e100-9. doi: 10.1182/blood-2013-12-541698. Epub 2014 Mar 20.
• [14] Trials for the co-expression of the merozoite surface protein-1 and circumsporozoite protein genes of Plasmodium vivax.Exp Parasitol. 2011 Nov;129(3):227-33. doi: 10.1016/j.exppara.2011.08.014. Epub 2011 Aug 28.
• [15] TOLLIP gene variant is associated with Plasmodium vivax malaria in the Brazilian Amazon.Malar J. 2017 Mar 13;16(1):116. doi: 10.1186/s12936-017-1754-7.