Details of Disease

General Information of Disease (ID: DISQGN78)

• Disease Name: Social phobia
• Synonyms: social anxiety disorder
• Disease Class: 6B04: Social anxiety disorder
• Definition: An anxiety disorder characterized by an intense, irrational fear of one or more social or performance situations in which the individual believes that he or she will be scrutinized by others. Exposure to social situations immediately provokes an anxiety response. In adults, the social phobia is recognized as excessive or unreasonable.
• Disease Hierarchy:
  DISX6DUL: Phobic disorder
  DISQGN78: Social phobia
• ICD Code:
  ICD-11: ICD-11: 6B04
  ICD-10: ICD-10: F40.1
• Disease Identifiers:
  MONDO ID: MONDO_0001247
  MESH ID: D000072861
  UMLS CUI: C0031572
  MedGen ID: 19254
  SNOMED CT ID: 25501002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
FKW00GA	DMPXH7N	Phase 2	NA	[1]
TGWOOAA	DMI57ZA	Phase 2	NA	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SLC2A9	TTIF3GB	Limited	Genetic Variation	[3]
OXTR	TTSCIUP	moderate	Genetic Variation	[4]
GAD1	TTKGEP3	Strong	Biomarker	[5]
RGS2	TTKB7T3	Strong	Biomarker	[6]
SLC6A4	TT3ROYC	Strong	Genetic Variation	[7]

This Disease Is Related to 6 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DYNLL2	OTLIT58K	Limited	Biomarker	[8]
FMR1	OTWEV0T5	moderate	Genetic Variation	[9]
MANEA	OTV7L8I6	Strong	Biomarker	[10]
PDSS1	OTXGVHAB	Strong	Biomarker	[11]
SEPHS1	OTZ19I59	Strong	Biomarker	[11]
TBX4	OTW58FG4	Strong	Biomarker	[11]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Clinical pipeline report, company report or official report of Fabre-Kramer Pharmaceuticals.
• [3] Associations of serum uric acid and SLC2A9 variant with depressive and anxiety disorders: a population-based study.PLoS One. 2013 Oct 29;8(10):e76336. doi: 10.1371/journal.pone.0076336. eCollection 2013.
• [4] Attachment style and oxytocin receptor gene variation interact in influencing social anxiety.World J Biol Psychiatry. 2016;17(1):76-83. doi: 10.3109/15622975.2015.1091502. Epub 2015 Oct 21.
• [5] Treatment of anxiety and mood comorbidities in cognitive-behavioral and psychodynamic therapies for panic disorder.J Psychiatr Res. 2019 Jul;114:34-40. doi: 10.1016/j.jpsychires.2019.04.009. Epub 2019 Apr 12.
• [6] Influence of RGS2 on sertraline treatment for social anxiety disorder.Neuropsychopharmacology. 2014 May;39(6):1340-6. doi: 10.1038/npp.2013.301. Epub 2013 Oct 24.
• [7] High social support buffers the effects of 5-HTTLPR genotypes within social anxiety disorder.Eur Arch Psychiatry Clin Neurosci. 2014 Aug;264(5):433-9. doi: 10.1007/s00406-013-0481-5. Epub 2014 Jan 10.
• [8] An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders.Biol Psychiatry. 2008 Oct 15;64(8):672-680. doi: 10.1016/j.biopsych.2008.06.002. Epub 2008 Jul 17.
• [9] Social anxiety and autism spectrum traits among adult FMR1 premutation carriers.Clin Genet. 2017 Jan;91(1):111-114. doi: 10.1111/cge.12791. Epub 2016 May 26.
• [10] The -endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder.Transl Psychiatry. 2014 Jan 28;4(1):e353. doi: 10.1038/tp.2013.122.
• [11] Factors associated with social anxiety in South Korean adults with epilepsy.Epilepsy Behav. 2019 Dec;101(Pt A):106569. doi: 10.1016/j.yebeh.2019.106569. Epub 2019 Oct 30.