Details of Disease

General Information of Disease (ID: DISSVWOE)

Disease Name	Retinal vein occlusion
Synonyms	occlusion, of retinal vein; retinal vein occlusion
Disease Class	9B74: Retinal vascular occlusion
Definition	An occlusion of the retinal vein.
Disease Hierarchy	DISRC604: Retinal vascular occlusion DISSVWOE: Retinal vein occlusion
ICD Code	ICD-11 ICD-11: 9B74
Disease Identifiers	MONDO ID MONDO_0006951 MESH ID D012170 UMLS CUI C0035328 MedGen ID 19763 HPO ID HP:0012636 SNOMED CT ID 1237532002

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
RG7921	DMCF71C	Phase 1	NA	[1]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 10 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AQP1	TTSF1KH	Limited	Biomarker	[2]
KCNJ10	TTG140O	Limited	Biomarker	[2]
VEGFB	TTPJQHE	Limited	Biomarker	[2]
F2	TT6L509	Strong	Genetic Variation	[3]
F5	TT1O264	Strong	Genetic Variation	[4]
FGF2	TTGKIED	Strong	Biomarker	[5]
ITGA2	TTSJ542	Strong	Biomarker	[6]
MAPKAP1	TTWDKCL	Strong	Biomarker	[7]
VEGFA	TT3LJ9K	Strong	Biomarker	[8]
VKORC1	TTEUC8H	Definitive	Genetic Variation	[9]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 DTT(s)

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AQP4	OTA9MYD5	Limited	Biomarker	[2]
HYLS1	OT3SW5UC	Limited	Genetic Variation	[10]
TDRD9	OTS4UBI8	Limited	Genetic Variation	[10]
CCL13	OTNX0JD0	Strong	Altered Expression	[11]
CCL25	OTLWJ8CJ	Strong	Altered Expression	[11]
PPP1R12A	OT4AVU95	Strong	Posttranslational Modification	[12]
RPTOR	OT4TQZ9F	Strong	Biomarker	[7]
TNPO1	OT7W2CM8	Strong	Biomarker	[7]
------------------------------------------------------------------------------------


⏷ Show the Full List of 8 DOT(s)

References

1	Clinical pipeline report, company report or official report of Roche
2	Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion.Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1175-83. doi: 10.1007/s00417-011-1683-z. Epub 2011 Apr 13.
3	Genetic correlation between Prothrombin G20210A polymorphism and retinal vein occlusion risk.Braz J Med Biol Res. 2019 Apr 8;52(4):e8217. doi: 10.1590/1414-431X20198217.
4	Association of retinal vein occlusion, homocysteine, and the thrombophilic mutations in a Turkish population: A case-control study.Ophthalmic Genet. 2017 Jul-Aug;38(4):352-356. doi: 10.1080/13816810.2016.1235716. Epub 2017 Jan 13.
5	Alterations in protein tyrosine kinase pathways following retinal vein occlusion in the rat.Curr Eye Res. 1999 Mar;18(3):231-9. doi: 10.1076/ceyr.18.3.231.5369.
6	The platelet glycoprotein Ia/IIa gene polymorphism C807T/G873A: a novel risk factor for retinal vein occlusion.Eye (Lond). 2003 Aug;17(6):772-7. doi: 10.1038/sj.eye.6700452.
7	The anti-inflammatory and anti-oxidative effects of conbercept in treatment of macular edema secondary to retinal vein occlusion.Biochem Biophys Res Commun. 2019 Jan 22;508(4):1264-1270. doi: 10.1016/j.bbrc.2018.12.049. Epub 2018 Dec 15.
8	Association of Disorganization of Retinal Inner Layers With Visual Acuity Response to Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema Secondary to Retinal Vein Occlusion.JAMA Ophthalmol. 2019 Jan 1;137(1):38-46. doi: 10.1001/jamaophthalmol.2018.4484.
9	Predictive value of the vitamin K epoxide reductase complex subunit 1 G-1639A and C1173T single nucleotide polymorphisms in retinal vein occlusion.Clin Exp Ophthalmol. 2012 Sep-Oct;40(7):743-8. doi: 10.1111/j.1442-9071.2012.02780.x. Epub 2012 May 17.
10	Low health literacy levels in patients with chronic retinal disease.BMC Ophthalmol. 2019 Aug 8;19(1):174. doi: 10.1186/s12886-019-1191-1.
11	Comprehensive analysis of vitreous chemokines involved in ischemic retinal vein occlusion.Mol Vis. 2019 Nov 15;25:756-765. eCollection 2019.
12	Effects of ripasudil, a ROCK inhibitor, on retinal edema and nonperfusion area in a retinal vein occlusion murine model.J Pharmacol Sci. 2018 Jun;137(2):129-136. doi: 10.1016/j.jphs.2018.06.010. Epub 2018 Jun 19.