Details of Disease

General Information of Disease (ID: DISV1F5R)

• Disease Name: Hypogonadism, male
• Synonyms: hypogonadism and testicular atrophy; hypogonadism, male
• Definition: Editor note: check OMIM
• Disease Hierarchy:
  DISYKSRF: Genetic disease
  DISICMNI: Hypogonadism
  DISV1F5R: Hypogonadism, male
• Disease Identifiers:
  MONDO ID: MONDO_0009421
  MESH ID: D005058
  UMLS CUI: C0151721
  OMIM ID: 241100
  MedGen ID: 57480
  HPO ID: HP:0000026
  SNOMED CT ID: 48723006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Fluoxymesterone	DMUHCF1	Approved	Small molecular drug	[1]
Methyltestosterone	DMWLFGO	Approved	Small molecular drug	[2]
Testosterone	DM7HUNW	Approved	Small molecular drug	[3]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Androgen	DM19A89	Investigative	Small molecular drug	[4]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
KISS1R	TT3KBZY	moderate	Biomarker	[5]
NR0B1	TTTK36V	moderate	Biomarker	[6]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
G6PC3	DEE1B8O	Strong	Genetic Variation	[7]

This Disease Is Related to 10 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SRY	OT516T6D	moderate	Genetic Variation	[8]
AMH	OT5FH4BD	Strong	Biomarker	[9]
B4GALNT1	OTCY80HS	Strong	Biomarker	[10]
BOLL	OT5FAEJJ	Strong	Altered Expression	[11]
INSL3	OT7KUNTE	Strong	Altered Expression	[12]
L3MBTL2	OTKX1XIX	Strong	Biomarker	[13]
LHB	OT5GBOVJ	Strong	Genetic Variation	[14]
RXFP2	OT7SAT9U	Strong	Biomarker	[12]
SOHLH1	OT3RBLSK	Strong	Biomarker	[15]
SPAG5	OTCLJ56M	Strong	Genetic Variation	[16]

References

• [1] Fluoxymesterone FDA Label
• [2] Methyltestosterone FDA Label
• [3] Testosterone FDA Label
• [4] Diabetes Mellitus and Male Aging: Pharmacotherapeutics and Clinical Implications. Curr Pharm Des. 2017;23(30):4475-4483.
• [5] Downregulation of leptin receptor and kisspeptin/GPR54 in the murine hypothalamus contributes to male hypogonadism caused by high-fat diet-induced obesity.Endocrine. 2018 Oct;62(1):195-206. doi: 10.1007/s12020-018-1646-9. Epub 2018 Jun 13.
• [6] Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function.Nat Genet. 1996 Apr;12(4):404-9. doi: 10.1038/ng0496-404.
• [7] Testicular failure in a patient with G6PC3 deficiency.Pediatr Res. 2014 Aug;76(2):197-201. doi: 10.1038/pr.2014.64. Epub 2014 May 5.
• [8] Cytogenetic and molecular characterization of the derivative Y chromosome: a case study of an azoospermic patient.Clin Genet. 2007 Nov;72(5):460-3. doi: 10.1111/j.1399-0004.2007.00885.x.
• [9] Correlation of anti-Mullerian hormone with humanchorionic gonadotropin test in the evaluation of testicular function of children with 46 XY male hypogonadism: Use of anti-Mullerian hormone as abiomarker.J Paediatr Child Health. 2020 Mar;56(3):411-419. doi: 10.1111/jpc.14643. Epub 2019 Oct 15.
• [10] Loss of Enzyme Activity in Mutated B4GALNT1 Gene Products in Patients with Hereditary Spastic Paraplegia Results in Relatively Mild Neurological Disorders: Similarity with Phenotypes of B4galnt1 Knockout Mice.Neuroscience. 2019 Jan 15;397:94-106. doi: 10.1016/j.neuroscience.2018.11.034. Epub 2018 Dec 4.
• [11] Messenger RNA transcripts of the meiotic regulator BOULE in the testis of azoospermic men and their application in predicting the success of sperm retrieval.Hum Reprod. 2005 Mar;20(3):782-8. doi: 10.1093/humrep/deh647. Epub 2004 Dec 9.
• [12] Protective Role of Testicular Hormone INSL3 From Atrophy and Weakness in Skeletal Muscle.Front Endocrinol (Lausanne). 2018 Sep 28;9:562. doi: 10.3389/fendo.2018.00562. eCollection 2018.
• [13] L3MBTL2 regulates chromatin remodeling during spermatogenesis.Cell Death Differ. 2019 Nov;26(11):2194-2207. doi: 10.1038/s41418-019-0283-z. Epub 2019 Feb 13.
• [14] Homozygous nonsense mutation Trp28X in the LHB gene causes male hypogonadism.J Assist Reprod Genet. 2018 May;35(5):913-919. doi: 10.1007/s10815-018-1133-5. Epub 2018 Feb 23.
• [15] Mutations in SOHLH1 gene associate with nonobstructive azoospermia.Hum Mutat. 2010 Jul;31(7):788-93. doi: 10.1002/humu.21264.
• [16] Critical roles of Astrin in the mitosis of immature rat Sertoli cells.Biochem Biophys Res Commun. 2017 May 13;486(4):958-964. doi: 10.1016/j.bbrc.2017.03.137. Epub 2017 Mar 27.