Details of Disease

General Information of Disease (ID: DISXVSAE)

• Disease Name: Contraception
• Disease Class: QA21: Contraceptive management
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISXVSAE: Contraception
• ICD Code: ICD-11: ICD-11: QA21

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 13 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Copper	DMTJMDK	Approved	Small molecular drug	[1]
Desogestrel	DM27U4Y	Approved	Small molecular drug	[2]
Drospirenone	DM1A9W3	Approved	Small molecular drug	[3]
Ethynodiol Diacetate	DMZM84R	Approved	Small molecular drug	[4]
Etonogestrel	DMKA8J4	Approved	Small molecular drug	[5]
Levonorgestrel	DM1DP7T	Approved	Small molecular drug	[6]
Mestranol	DMG3F94	Approved	Small molecular drug	[7]
Nonoxynol-9	DM6WWOT	Approved	Small molecular drug	[1]
Norgestimate	DMYP4XC	Approved	Small molecular drug	[8]
Oestradiol valerate and dienogest	DMZK0FQ	Approved	Small molecular drug	[1]
Progesterone	DMUY35B	Approved	Small molecular drug	[9]
Segesterone acetate; ethinyl estradiol	DMFEGB0	Approved	NA	[10]
Ulipristal	DMBNI20	Approved	Small molecular drug	[11]

This Disease is Treated as An Indication in 9 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
LCS 16	DMV5EYE	Phase 3	NA	[12]
Polyacrylic acid	DMFMU4A	Phase 2/3	Small molecular drug	[13]
Juvenile chondrocyte grafts	DM2W0XU	Phase 2	NA	[14]
MK-8175A	DMKPKHD	Phase 2	NA	[15]
MK-8342	DMD6E5W	Phase 2	NA	[15]
MK-8342B	DM1WN3R	Phase 2	NA	[15]
Tosagestin	DM2HDTM	Phase 2	Small molecular drug	[16]
ATD transdermal gel	DMIMH8L	Phase 1	NA	[17]
TESTOSTERONE BUCICLATE	DM3DUHL	Phase 1	Small molecular drug	[18]

This Disease is Treated as An Indication in 4 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ORG-33628	DMWZXF7	Discontinued in Phase 2	Small molecular drug	[19]
Org-31710	DMZKTU5	Discontinued in Phase 1	Small molecular drug	[20]
HCG contraceptive vaccine	DM2LQMQ	Terminated	NA	[22]
Zona pellucida contraceptive vaccine	DM0TRUV	Terminated	NA	[23]

This Disease is Treated as An Indication in 1 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Prevecon	DM5E1DL	Preclinical	NA	[21]

This Disease is Treated as An Indication in 4 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
FSHR NAM	DMPRMOD	Investigative	NA	[24]
HRA-081025	DMZ29MN	Investigative	NA	[25]
HRA-081035	DMAGY9B	Investigative	NA	[25]
Protectaid	DM059Z3	Investigative	NA	[25]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7065).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2874).
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7072).
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7590).
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2881).
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7087).
• [8] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7091).
• [9] ClinicalTrials.gov (NCT00822900) Progesterone for the Treatment of Traumatic Brain Injury III. U.S. National Institutes of Health.
• [10] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [11] Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
• [12] ClinicalTrials.gov (NCT00528112) Levonorgestrel Contraceptive Intrauterine Systems (LCS) Pearl Index Study. U.S. National Institutes of Health.
• [13] ClinicalTrials.gov (NCT00065858) Effectiveness of BufferGel as a Vaginal Contraceptive. U.S. National Institutes of Health.
• [14] Clinical pipeline report, company report or official report of ISTO Technologies.
• [15] Clinical pipeline report, company report or official report of Merck (May 7, 2015).
• [16] Excretion balance and metabolism of the progestagen Org 30659 in healthy postmenopausal women. J Steroid Biochem Mol Biol. 2000 May;73(1-2):39-48.
• [17] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024900)
• [18] Testosterone buciclate (20 Aet-1) in hypogonadal men: pharmacokinetics and pharmacodynamics of the new long-acting androgen ester. J Clin Endocrinol Metab. 1992 Nov;75(5):1204-10.
• [19] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018847)
• [20] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002550)
• [21] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011649)
• [22] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015099)
• [23] Contraceptive vaccines based on the zona pellucida glycoproteins for dogs and other wildlife population management. Am J Reprod Immunol. 2011 Jul;66(1):51-62.
• [24] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 253).
• [25] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [26] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016303)