Details of Disease

General Information of Disease (ID: DISZFTMH)

• Disease Name: Hantavirus infection
• Synonyms: infections, Hantavirus; disease caused by hantavirus; Hantavirus disease or disorder; disease due to hantavirus; Hantavirus caused disease or disorder; Hantavirus infectious disease; Hantavirus infection
• Disease Class: 1D62: Hantavirus disease
• Definition: Any infection caused by a virus of the genus Hantavirus, which is transmitted by aerosolized rodent excreta or rodent bites, that can result in a variety of clinical manifestations from hemorrhagic fever with renal syndrome to a pulmonary syndrome.
• Disease Hierarchy:
  DISNGS35: Bunyaviridae infectious disease
  DISEM33Q: Infectious disease
  DISZFTMH: Hantavirus infection
• ICD Code: ICD-11: ICD-11: 1D62
• Disease Identifiers:
  MONDO ID: MONDO_0005780
  MESH ID: D018778
  UMLS CUI: C0242994
  MedGen ID: 67028
  SNOMED CT ID: 359761005

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Youerjian	DMSCXJ5	Approved	NA	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
MUTYH	TTNB0ZK	Limited	Biomarker	[2]
PRDX5	TTLPJWH	Strong	Altered Expression	[3]
PTGDR2	TTQDMX5	Strong	Biomarker	[4]
TFF1	TTNOJIZ	Strong	Biomarker	[5]

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC24A5	DTAWCS9	Strong	Altered Expression	[6]
SLC35D3	DT63MZQ	Strong	Biomarker	[7]

This Disease Is Related to 22 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
HPS6	OTXL5KQW	moderate	Biomarker	[8]
MREG	OT0LUIRG	moderate	Biomarker	[9]
SH2D1A	OTLU49I5	moderate	Biomarker	[10]
AP3B1	OTYTIH5Q	Strong	Biomarker	[5]
AP3D1	OTJLI0IM	Strong	Genetic Variation	[11]
ATF5	OT03QCLM	Strong	Biomarker	[10]
BLOC1S6	OT96NE03	Strong	Biomarker	[12]
BMPER	OTBYON4H	Strong	Altered Expression	[13]
CD63	OT2UGZA9	Strong	Biomarker	[14]
DMP1	OTBWBWW7	Strong	Biomarker	[15]
DTNBP1	OT9UQT2S	Strong	Biomarker	[16]
ETV1	OT6PMJIK	Strong	Altered Expression	[17]
FGL1	OTT0QHQ1	Strong	Genetic Variation	[18]
HPS1	OTKS5I7T	Strong	Genetic Variation	[19]
HPS3	OTAKROK7	Strong	Genetic Variation	[19]
HPS4	OTBTW01J	Strong	Genetic Variation	[20]
HPS5	OTLO2374	Strong	Biomarker	[21]
MBD4	OTWR9YXE	Strong	Genetic Variation	[22]
RIMS2	OTQASWDH	Strong	Genetic Variation	[23]
RNPC3	OTW5MKC1	Strong	Biomarker	[24]
SFTPB	OTOHS07E	Strong	Biomarker	[25]
PCDH1	OT7KDEL3	Definitive	Biomarker	[26]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Colorectal polyposes: from phenotype to diagnosis.Pathol Res Pract. 2008;204(7):431-47. doi: 10.1016/j.prp.2008.03.008. Epub 2008 Jun 9.
• [3] Hermansky-Pudlak syndrome in a Swiss population.Dermatology. 1993;187(4):248-56. doi: 10.1159/000247258.
• [4] Chitinase 3-like-1 and its receptors in Hermansky-Pudlak syndrome-associated lung disease.J Clin Invest. 2015 Aug 3;125(8):3178-92. doi: 10.1172/JCI79792. Epub 2015 Jun 29.
• [5] Different functions of biogenesis of lysosomal organelles complex 3 subunit 1 (Hps1) and adaptor-related protein complex 3, beta 1 subunit (Ap3b1) genes on spermatogenesis and male fertility.Reprod Fertil Dev. 2019 Apr;31(5):972-982. doi: 10.1071/RD18339.
• [6] Exome sequencing identifies SLC24A5 as a candidate gene for nonsyndromic oculocutaneous albinism. J Invest Dermatol. 2013 Jul;133(7):1834-40. doi: 10.1038/jid.2013.49. Epub 2013 Jan 30.
• [7] SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.Blood. 2012 Jul 12;120(2):404-14. doi: 10.1182/blood-2011-11-389551. Epub 2012 May 18.
• [8] The ophthalmic presentation of Hermansky-Pudlak syndrome 6.Br J Ophthalmol. 2016 Nov;100(11):1521-1524. doi: 10.1136/bjophthalmol-2015-308067. Epub 2016 Jan 28.
• [9] Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis.PLoS One. 2012;7(9):e42446. doi: 10.1371/journal.pone.0042446. Epub 2012 Sep 11.
• [10] Up-regulation of activating transcription factor-5 suppresses SAP expression to activate T cells in hemophagocytic syndrome associated with Epstein-Barr virus infection and immune disorders.Am J Pathol. 2008 Nov;173(5):1397-405. doi: 10.2353/ajpath.2008.080440. Epub 2008 Oct 2.
• [11] Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome. Blood. 2016 Feb 25;127(8):997-1006. doi: 10.1182/blood-2015-09-671636. Epub 2016 Jan 7.
• [12] A BLOC-1 mutation screen reveals that PLDN is mutated in Hermansky-Pudlak Syndrome type 9. Am J Hum Genet. 2011 Jun 10;88(6):778-787. doi: 10.1016/j.ajhg.2011.05.009.
• [13] Cyclooxygenase-2 promotes pulmonary intravascular macrophage accumulation by exacerbating BMP signaling in rat experimental hepatopulmonary syndrome.Biochem Pharmacol. 2017 Aug 15;138:205-215. doi: 10.1016/j.bcp.2017.06.117. Epub 2017 Jun 19.
• [14] Novel mutation in two brothers with Hermansky Pudlak syndrome type 3.Blood Cells Mol Dis. 2017 Sep;67:75-80. doi: 10.1016/j.bcmd.2017.03.001. Epub 2017 Mar 6.
• [15] Dentin matrix protein 1 correlates with the severity of hemorrhagic fever with renal syndrome and promotes hyper-permeability of endothelial cells infected by Hantaan virus.Microbes Infect. 2019 Aug-Sep;21(7):321-327. doi: 10.1016/j.micinf.2019.01.003. Epub 2019 Feb 5.
• [16] Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex. Blood. 2004 Nov 15;104(10):3181-9. doi: 10.1182/blood-2004-04-1538. Epub 2004 Jul 20.
• [17] ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes.Sci Rep. 2018 Jul 2;8(1):9944. doi: 10.1038/s41598-018-28239-7.
• [18] Instability of BLOC-2 and BLOC-3 in Chinese patients with Hermansky-Pudlak syndrome.Pigment Cell Melanoma Res. 2019 May;32(3):373-380. doi: 10.1111/pcmr.12748. Epub 2018 Nov 22.
• [19] Hermansky-Pudlak syndrome and oculocutaneous albinism in Chinese children with pigmentation defects and easy bruising.Orphanet J Rare Dis. 2019 Feb 21;14(1):52. doi: 10.1186/s13023-019-1023-7.
• [20] A novel mutation causes Hermansky-Pudlak syndrome type 4 with pulmonary fibrosis in 2 siblings from China.Medicine (Baltimore). 2019 Aug;98(33):e16899. doi: 10.1097/MD.0000000000016899.
• [21] Hermansky-Pudlak syndrome subtype 5 (HPS-5) novel mutation in a 65 year-old with oculocutaneous hypopigmentation and mild bleeding diathesis: The importance of recognizing a subtle phenotype.Platelets. 2018 Jan;29(1):91-94. doi: 10.1080/09537104.2017.1361019. Epub 2017 Nov 1.
• [22] Hyperplastic polyposis syndrome: phenotypic presentations and the role of MBD4 and MYH.Gastroenterology. 2006 Jul;131(1):30-9. doi: 10.1053/j.gastro.2006.03.046.
• [23] rim2 (recombination-induced mutation 2) is a new allele of pearl and a mouse model of human Hermansky-Pudlak syndrome (HPS): genetic and physical mapping.Mamm Genome. 1998 Jan;9(1):2-7. doi: 10.1007/s003359900670.
• [24] Genetic properties of medium (M) and small (S) genomic RNA segments of Seoul hantavirus isolated from Rattus norvegicus and antigenicity analysis of recombinant nucleocapsid protein.Virus Genes. 2007 Jan;34(1):23-30. doi: 10.1007/s11262-006-0005-8. Epub 2006 Aug 22.
• [25] Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes.Am J Respir Cell Mol Biol. 2018 May;58(5):566-574. doi: 10.1165/rcmb.2017-0324MA.
• [26] Hantavirus entry: Perspectives and recent advances.Adv Virus Res. 2019;104:185-224. doi: 10.1016/bs.aivir.2019.07.002. Epub 2019 Aug 7.