Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT95T48Q)

• DOT Name: Costars family protein ABRACL (ABRACL)
• Synonyms: ABRA C-terminal-like protein
• Gene Name: ABRACL
• Related Disease:
  Gastric cancer
  Stomach cancer
• UniProt ID: ABRAL_HUMAN
• PDB ID: 2L2O
• Pfam ID: PF14705
• Sequence:
  MNVDHEVNLLVEEIHRLGSKNADGKLSVKFGVLFRDDKCANLFEALVGTLKAAKRRKIVT
  YPGELLLQGVHDDVDIILLQD

Molecular Interaction Atlas (MIA) of This DOT

2 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Gastric cancer	DISXGOUK	Definitive	Altered Expression	[1]
Stomach cancer	DISKIJSX	Definitive	Altered Expression	[1]

4 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate decreases the methylation of Costars family protein ABRACL (ABRACL).	[2]
Fulvestrant	DM0YZC6	Approved	Fulvestrant increases the methylation of Costars family protein ABRACL (ABRACL).	[11]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the methylation of Costars family protein ABRACL (ABRACL).	[13]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A decreases the methylation of Costars family protein ABRACL (ABRACL).	[11]

11 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Ciclosporin	DMAZJFX	Approved	Ciclosporin increases the expression of Costars family protein ABRACL (ABRACL).	[3]
Tretinoin	DM49DUI	Approved	Tretinoin increases the expression of Costars family protein ABRACL (ABRACL).	[4]
Acetaminophen	DMUIE76	Approved	Acetaminophen decreases the expression of Costars family protein ABRACL (ABRACL).	[5]
Estradiol	DMUNTE3	Approved	Estradiol decreases the expression of Costars family protein ABRACL (ABRACL).	[6]
Ivermectin	DMDBX5F	Approved	Ivermectin decreases the expression of Costars family protein ABRACL (ABRACL).	[7]
Quercetin	DM3NC4M	Approved	Quercetin affects the expression of Costars family protein ABRACL (ABRACL).	[3]
Testosterone	DM7HUNW	Approved	Testosterone decreases the expression of Costars family protein ABRACL (ABRACL).	[8]
Carbamazepine	DMZOLBI	Approved	Carbamazepine affects the expression of Costars family protein ABRACL (ABRACL).	[9]
Marinol	DM70IK5	Approved	Marinol increases the expression of Costars family protein ABRACL (ABRACL).	[10]
Urethane	DM7NSI0	Phase 4	Urethane decreases the expression of Costars family protein ABRACL (ABRACL).	[12]
Milchsaure	DM462BT	Investigative	Milchsaure affects the expression of Costars family protein ABRACL (ABRACL).	[14]

References

• [1] High Expression of ABRACL Is Associated with Tumorigenesis and Affects Clinical Outcome in Gastric Cancer.Genet Test Mol Biomarkers. 2019 Feb;23(2):91-97. doi: 10.1089/gtmb.2018.0195. Epub 2019 Jan 24.
• [2] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [3] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [4] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [5] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [6] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [7] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [8] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [9] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [10] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [11] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [12] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [13] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [14] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.