Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5UFZX)

Drug Name

Diazaborines Drug Info

Synonyms

KBPMSEXASFSGEI-WRBBICKQSA-N; Neomycin B-arginine conjugate; NeoR; AC1LAWYH; Hexaarginine-Neomycin B Conjugate; [D-Streptamine, O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1fwdarw4)-O-[O-2,6-diamino-2,6-dideoxy-beta-L-idopyranyl- (1fwdarw3)-beta-D-ribofuranosyl-(1fwdarw5)]-2-deoxy]-arginine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 496913
TTD Drug ID: DM5UFZX

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Plasmodium Enoyl-ACP reductase (Malaria fabI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[4]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[5]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[5]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[6]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[6]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[6]
Thiolactomycin	DMBAWDG	Malaria	1F40-1F45	Investigative	[3]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[6]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[6]
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Drug(s) Targeting Human immunodeficiency virus TAR RNA (HIV TAR-RNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chimeric small nucleolar RNA-TAR decoy	DMJATBL	Discovery agent	N.A.	Investigative	[7]
2,4-diaminoquinozalines and quinoxaline-2,3-diones	DMS1YXL	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial NADH-dependent enoyl-ACP reductase 1 (Bact fabI1)	TTCH81V	FABI1_RHIME	Inhibitor	[2]
Bacterial NADH-dependent enoyl-ACP reductase 2 (Bact fabI2)	TT283NK	FABI2_RHIME	Inhibitor	[2]
Human immunodeficiency virus TAR RNA (HIV TAR-RNA)	TTNSXG2	NOUNIPROTAC	Inhibitor	[1]
Plasmodium Enoyl-ACP reductase (Malaria fabI)	TTNX2CS	Q965D5_PLAFA	Inhibitor	[2]

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References

1	Neomycin B-arginine conjugate, a novel HIV-1 Tat antagonist: synthesis and anti-HIV activities. Biochemistry. 2001 Dec 25;40(51):15612-23.
2	Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97.
3	Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
4	Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75.
5	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6	Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
7	A nucleolar TAR decoy inhibitor of HIV-1 replication. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14047-52.
8	RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86.