Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7FZU2)

• Drug Name: 5-chloro-4-methyl-3,4-dihydroquinazolin-2-amine Drug Info
• Synonyms: CHEMBL270177; 918134-82-4; 2-Quinazolinamine, 5-chloro-1,4-dihydro-4-methyl-; 5-Chloro-4-methyl-1,4-dihydroquinazolin-2-amine; SCHEMBL1381915; CTK3H8599; DTXSID00581041; XFMPGBXLGWZMQP-UHFFFAOYSA-N; BDBM50371466

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 16006492
  CAS Number: CAS 918134-82-4
  TTD Drug ID: DM7FZU2

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT 1D receptor (HTR1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[2]
Eletriptan	DMW649X	Migraine	8A80	Approved	[3]
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[3]
Frovatriptan	DM7RE8P	Migraine	8A80	Approved	[3]
Sumatriptan	DMVYXR8	Cluster headache	8A81.0	Approved	[4]
Rizatriptan	DMDJMA3	Migraine	8A80	Approved	[5]
Almogran	DM7I64Z	Migraine	8A80	Approved	[6]
Neu-P11	DMIQDFW	Alzheimer disease	8A20	Phase 2	[7]
FKB01MD	DM2O7NM	N. A.	N. A.	Phase 2	[8]
NXN-188	DMMBAIH	Migraine	8A80	Phase 2	[9]

Drug(s) Targeting 5-HT 5A receptor (HTR5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[10]
(+/-)-nantenine	DM0L3GE	Discovery agent	N.A.	Investigative	[11]
SEROTONIN	DMOFCRY	Discovery agent	N.A.	Investigative	[12]
5-CT	DM260KD	Discovery agent	N.A.	Investigative	[13]
TFMPP	DMAC8TP	Discovery agent	N.A.	Investigative	[14]
5,6-dichloro-3,4-dihydroquinazolin-2-amine	DMN1S35	Discovery agent	N.A.	Investigative	[1]
MPDT	DMYX31S	Discovery agent	N.A.	Investigative	[15]
5-chloro-3,4-dihydroquinazolin-2-amine	DMKEFJ0	Discovery agent	N.A.	Investigative	[1]
EDMT	DMS3AXK	Discovery agent	N.A.	Investigative	[15]
[3H]5-CT	DMEAHFZ	Discovery agent	N.A.	Investigative	[16]

Drug(s) Targeting 5-HT 1A receptor (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[3]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[17]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[18]
Vilazodone	DM4LECQ	Major depressive disorder	6A70.3	Approved	[19]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[20]
Gepirone	DMGX5Q0	Major depressive disorder	6A70.3	Approved	[21]
TERTATOLOL	DM2L3D5	Hypertension	BA00-BA04	Approved	[22]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[23]
Treximet	DMU54QB	Migraine	8A80	Approved	[24]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[25]

Drug(s) Targeting 5-HT 7 receptor (HTR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[8]
JNJ-18038683	DMV1T59	Major depressive disorder	6A70.3	Phase 2	[26]
AVN-101	DMOGFNI	Cognitive impairment	6D71	Phase 2	[27]
ATI-9242	DM6GKMU	Schizophrenia	6A20	Phase 1	[28]
PMID30124346-Compound-34TABLE4	DM2G3VE	Attention deficit hyperactivity disorder	6A05.Z	Patented	[29]
PMID30124346-Compound-13TABLE4	DMHTJVA	Attention deficit hyperactivity disorder	6A05.Z	Patented	[29]
Carbamide derivative 2	DMW5GI3	N. A.	N. A.	Patented	[30]
4-oxadiazole derivative 1	DMWFHKR	N. A.	N. A.	Patented	[30]
SB-269970	DM8WTGA	Sleep-wake disorder	7A00-7B2Z	Terminated	[31]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one	DMM9X0G	Discovery agent	N.A.	Investigative	[32]

Drug(s) Targeting 5-HT 2C receptor (HTR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[33]
Lorcaserin	DMG6OYJ	Obesity	5B81	Approved	[34]
Tramadol	DMRQD04	Osteoarthritis	FA00-FA05	Approved	[35]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[36]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[37]
Methysergide	DM1EF73	Migraine	8A80	Approved	[38]
Eltoprazine	DMW6C81	Attention deficit hyperactivity disorder	6A05.Z	Phase 3	[39]
M100907	DM7ZFBA	Sleep-wake disorder	7A00-7B2Z	Phase 3	[40]
SR46349B	DM1ODMR	Primary insomnia	7A00	Phase 3	[41]
Vabicaserin	DM9GZW6	Psychotic disorder	6A20-6A25	Phase 2	[42]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]
5-HT 1D receptor (HTR1D)	TT6MSOK	5HT1D_HUMAN	Inhibitor	[1]
5-HT 2C receptor (HTR2C)	TTWJBZ5	5HT2C_HUMAN	Inhibitor	[1]
5-HT 5A receptor (HTR5A)	TTRUFDT	5HT5A_HUMAN	Inhibitor	[1]
5-HT 7 receptor (HTR7)	TTO9X1H	5HT7R_HUMAN	Inhibitor	[1]

References

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