Details of the Drug-Related molecule(s) Interaction Atlas

Diiodo-l-thyronine Drug Info

L-3,3'-Diiodothyronine; (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]propanoic acid; (S)-2-amino-3-(4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl)propanoic acid; 3,3'-DEIODO-THYROXINE; 3,3'-Diiodo-L-thyronine; 3,3'-Diiodothyronine; 3,3'-Diiodothyronine, L-; 3,3'-T2; 3,3'-Diiodo-l-thyronine; 3L9U2Z4602; 4604-41-5; AC1L32DA; CHEBI:45698; CHEMBL1236140; EINECS 225-005-7; MFCD01863378; O-(4-Hydroxy-3-iodophenyl)-3-iodo-L-tyrosine; Tyrosine, O-(4-hydroxy-3-iodophenyl)-3-iodo-; UNII-3L9U2Z4602

Cross-matching ID

PubChem CID

107564

ChEBI ID

CHEBI:45698

CAS Number

CAS 4604-41-5

TTD Drug ID

DM917FE

INTEDE Drug ID

DR1949

General Information of Drug (ID: DM917FE)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

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Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[2]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[3]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[5]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[6]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[7]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[8]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[1]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[9]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sulfotransferase 1A1 (SULT1A1)^{Main DME}	DEYWLRK	ST1A1_HUMAN	Substrate	[1]

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References

1	Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
2	Progestagenic effects of tibolone are target gene-specific in human endometrial cells. J Soc Gynecol Investig. 2006 Sep;13(6):459-65.
3	Tamoxifen-induced adduct formation and cell stress in human endometrial glands. Drug Metab Dispos. 2010 Jan;38(1):200-7.
4	Proposed role of the sulfotransferase/sulfatase pathway in modulating yolk steroid effects. Integr Comp Biol. 2008 Sep;48(3):419-27.
5	Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65.
6	Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
7	Natural products isolated from Mexican medicinal plants: novel inhibitors of sulfotransferases, SULT1A1 and SULT2A1. Phytomedicine. 2001 Nov;8(6):481-8.
8	Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. 2010 Mar;40(3):184-94.
9	Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. Biochem Biophys Res Commun. 2005 Sep 23;335(2):417-23.
10	Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4.