Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9UCJK)

• Drug Name: Doripenem Drug Info
• Synonyms: Doribax; S 4661; S-4661; Doripenem (USAN/INN); (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Cholecystitis		Approved	[1]
Pyelonephritis		Approved	[1]
Urinary tract infection	GC08	Approved	[2]
Gram-positive bacterial infection	1B74-1G40	Phase 3	[3]

• Cross-matching ID:
  PubChem CID: 73303
  ChEBI ID: CHEBI:135928
  CAS Number: CAS 148016-81-3
  TTD Drug ID: DM9UCJK
  INTEDE Drug ID: DR0534

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Dihydropteroate synthetase (Bact folP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[6]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[7]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[8]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[9]
Sulfisoxazole	DMXLT8C	Acute otitis media	AB00	Approved	[10]
Sulfapyridine	DMIUYFH	Dermatitis herpetiformis	EB44	Approved	[11]
Gramicidin D	DMPT74U	Bacterial infection	1A00-1C4Z	Approved	[12]
Oritavancin	DM28D05	Bacterial infection	1A00-1C4Z	Approved	[3]
Faropenem	DMX7A5V	Gram-positive bacterial infection	1B74-1G40	Approved	[3]
Daptomycin	DMFDQ3I	Bacterial infection	1A00-1C4Z	Approved	[13]

Drug(s) Metabolized By Beta-lactamase (blaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[5]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[5]
Ertapenem	DM4S3O8	Bacterial infection	1A00-1C4Z	Approved	[5]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Dihydropteroate synthetase (Bact folP)	TT4ILYC	DHPS_ECOLI	Inhibitor	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Dehydropeptidase-I (DPEP1)	DEAMVR3	DPEP1_HUMAN	Substrate	[4]
Beta-lactamase (blaB)	DEC3G7M	A0A1S7IV31_ENTAS	Substrate	[5]

References

• [1] Doripenem FDA Label
• [2] 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
• [3] Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
• [4] Disposition, metabolism, and excretion of [14C]doripenem after a single 500-milligram intravenous infusion in healthy men. Antimicrob Agents Chemother. 2008 Oct;52(10):3478-83.
• [5] FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan. J Antimicrob Chemother. 2018 Nov 1;73(11):2969-2972.
• [6] In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52.
• [7] Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling. Bioorg Med Chem. 2008 May 15;16(10):5788-94.
• [8] Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. Ann Pharmacother. 1999 Sep;33(9):960-7.
• [9] The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
• [10] Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63.
• [11] A confirmatory method for the simultaneous extraction, separation, identification and quantification of Tetracycline, Sulphonamide, Trimethoprim an... J Chromatogr A. 2009 Nov 13;1216(46):8110-6.
• [12] Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles. Biochemistry. 2001 Oct 2;40(39):11676-86.
• [13] Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem Biol. 2004 Jul;11(7):949-57.