General Information of Drug (ID: DMAH4P8)

Drug Name
Quinoline derivative 13 Drug Info
Synonyms PMID27724045-Compound-8
Cross-matching ID
PubChem CID
25015093
TTD Drug ID
DMAH4P8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
VESNARINONE DMBKX3C Cardiac failure BD10-BD13 Approved [2]
M100907 DM7ZFBA Sleep-wake disorder 7A00-7B2Z Phase 3 [3]
HP-184 DMNOMV2 Multiple sclerosis 8A40 Phase 2 [4]
NITD609 DMQHBSX Malaria 1F40-1F45 Phase 2 [5]
ABT-229 DMN3S1B Pain MG30-MG3Z Phase 2 [6]
ISOQUINE DMR17YI Malaria 1F40-1F45 Phase 1 [7]
Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 1 DMC8935 N. A. N. A. Patented [8]
Isoindoline derivative 5 DMIUTQW N. A. N. A. Patented [9]
Isoindoline derivative 3 DM2MYL9 N. A. N. A. Patented [9]
Isoindoline derivative 4 DMP1NKI N. A. N. A. Patented [9]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting P2X purinoceptor 7 (P2RX7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CE-224535 DMFCLT6 Arthralgia ME82 Phase 2/3 [10]
AZD9056 DMJGYPK Chronic obstructive pulmonary disease CA22 Phase 2 [11]
LY3857210 DMZO2V2 Pain MG30-MG3Z Phase 2 [12]
BIL010t DMV1EA9 Alzheimer disease 8A20 Phase 1/2 [13]
EVT 401 DMOG8IE Rheumatoid arthritis FA20 Phase 1 [14]
SGM-1019 DMDAHEL Inflammatory bowel disease DD72 Phase 1 [15]
GSK1482160 DMWDQOV Pain MG30-MG3Z Phase 1 [16]
JNJ-55308942 DM0QZJX Anhedonia MB24.2 Phase 1 [13]
JNJ-54175446 DMQ5ZVK Major depressive disorder 6A70.3 Phase 1 [17]
JNJ-479655 DMDU6GN Alzheimer disease 8A20 Clinical trial [18]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
P2X purinoceptor 7 (P2RX7) TT473XN P2RX7_HUMAN Antagonist [1]
Voltage-gated potassium channel Kv11.1 (KCNH2) TTQ6VDM KCNH2_HUMAN Antagonist [1]

References

1 P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267.
2 Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2773-5.
3 Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists ... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3708-12.
4 Emerging drugs for spinal cord injury. Expert Opin Emerg Drugs. 2008 Mar;13(1):63-80.
5 Spiroindolones, a potent compound class for the treatment of malaria. Science. 2010 Sep 3;329(5996):1175-80.
6 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety. Bioorg Med Chem. 2010 Nov 1;18(21):7651-8.
7 Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for ... J Med Chem. 2009 Mar 12;52(5):1408-15.
8 Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46.
9 The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663.
10 Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate. J Rheumatol. 2012 Apr;39(4):720-7.
11 Clinical pipeline report, company report or official report of AstraZeneca (2009).
12 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
13 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
14 Molecular and functional properties of P2X receptors ecent progress and persisting challenges. Purinergic Signal. 2012 September; 8(3): 375-417.
15 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
16 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
17 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
18 Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567. Br J Pharmacol. 2013 Oct;170(3):624-40.