Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB1WF3)

• Drug Name: OPC-14523 Drug Info
• Synonyms: OPC-14523; UNII-1981OTB4DS; 1981OTB4DS; CHEMBL294144; 145969-30-8; OPC-14523 free base; SCHEMBL5022801; ZINC598353; BDBM50005656; 1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-methoxy-3,4-dihydro-2-quinolinone; L001554; 2(1H)-Quinolinone, 1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-3,4-dihydro-5-methoxy-

Indication

Disease Entry	ICD 11	Status	REF
Bulimia nervosa	6B81	Phase 2	[1]
Mood disorder	6A60-6E23	Phase 2	[1]
Female sexual arousal dysfunction	HA01.1	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 9892540
  CAS Number: CAS 145969-30-8
  TTD Drug ID: DMB1WF3

Molecule-Related Drug Atlas

Drug(s) Targeting Opioid receptor sigma 1 (OPRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[3]
Dextromethorphan Polistirex	DMEHCY5	Dry cough	MD12	Approved	[4]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[5]
AVP-786	DMV1SOR	Alzheimer disease	8A20	Phase 3	[6]
ADX N05	DMLBYRA	Mood disorder	6A60-6E23	Phase 3	[7]
Igmesine	DMH97XA	Major depressive disorder	6A70.3	Phase 2	[8]
ANAVEX 2-73	DM67OU4	Alzheimer disease	8A20	Phase 1	[9]
SSR-125047	DMSUFW6	Schizophrenia	6A20	Phase 1	[10]
SA-5845	DM6XZRL	Central nervous system disease	8A04-8D87	Phase 1	[11]
SSR-125329A	DMG6NI8	Immune System disease	4A01-4B41	Phase 1	[12]

Drug(s) Targeting 5-HT 1A receptor (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[4]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[13]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[14]
Vilazodone	DM4LECQ	Major depressive disorder	6A70.3	Approved	[15]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[16]
Gepirone	DMGX5Q0	Major depressive disorder	6A70.3	Approved	[17]
TERTATOLOL	DM2L3D5	Hypertension	BA00-BA04	Approved	[18]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[19]
Treximet	DMU54QB	Migraine	8A80	Approved	[20]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[5]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Modulator	[2]
Opioid receptor sigma 1 (OPRS1)	TT5TPI6	SGMR1_HUMAN	Modulator	[2]

References

• [1] Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today. 2007 Sep;12(17-18):757-66.
• [2] Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001 Dec;41(8):976-88.
• [3] Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. Drugs R D. 2005;6(3):174-7.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127)
• [6] Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
• [7] Clinical pipeline report, company report or official report of SK BioPhamaceuticals.
• [8] Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. J Pharmacol Exp Ther. 2006 Jun;317(3):1307-19.
• [9] 2011 Pipeline of Anavex.
• [10] The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
• [11] Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study. J Nucl Med. 2004 Nov;45(11):1939-45.
• [12] SSR125329A, a high affinity sigma receptor ligand with potent anti-inflammatory properties. Eur J Pharmacol. 2002 Dec 5;456(1-3):123-31.
• [13] Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. Handb Exp Pharmacol. 2005;(169):181-204.
• [14] Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors.Pharmacol Biochem Behav.2014 Sep;124:245-9.
• [15] 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
• [16] Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
• [17] Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.
• [18] Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993).
• [19] Urapidil. A reappraisal of its use in the management of hypertension. Drugs. 1998 Nov;56(5):929-55.
• [20] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).