Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFYCB4)

• Drug Name: carnosine Drug Info
• Synonyms: beta-alanyl-L-histidine; L-carnosine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 439224
  ChEBI ID: CHEBI:15727
  CAS Number: CAS 305-84-0
  TTD Drug ID: DMFYCB4
  VARIDT Drug ID: DR00645
  INTEDE Drug ID: DR2076

Molecule-Related Drug Atlas

Drug(s) Transported By Peptide transporter 1 (SLC15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[4]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[5]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[6]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[7]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[8]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[9]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[10]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[5]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[7]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[7]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Carnosine N-methyltransferase (CARNMT1) Main DME	DECY3P8	CARME_HUMAN	Substrate	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4559).
• [2] Transforming dietary peptides in promising lead compounds: the case of bioavailable carnosine analogs. Amino Acids. 2012 Jul;43(1):111-26.
• [3] UPF0586 protein C9orf41 homolog is anserine-producing methyltransferase. J Biol Chem. 2015 Jul 10;290(28):17190-205.
• [4] Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55.
• [5] Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18.
• [6] Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. Res Microbiol. 2017 Jun;168(5):443-449.
• [7] High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9.
• [8] The intestinal H+/peptide symporter PEPT1: structure-affinity relationships. Eur J Pharm Sci. 2004 Jan;21(1):53-60.
• [9] Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9.
• [10] Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61.