Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGCVT2)

Drug Name

9-anthroic acid Drug Info

Synonyms

anthracene-10-carboxylic acid; 9-AC

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2201
ChEBI ID: CHEBI:34507
CAS Number: CAS 723-62-6
TTD Drug ID: DMGCVT2

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Calcium-dependent chloride channel anoctamin (ANO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzbromarone	DMC3YUA	Gout	FA25	Approved	[7]
Crofelemer	DM4AMQZ	HIV-associated diarrhoea	1A2Z	Approved	[8]
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[2]
DIDS	DMKSQUB	Discovery agent	N.A.	Investigative	[2]
SITS	DMCMIUG	Discovery agent	N.A.	Investigative	[2]
DCDPC	DMG9BFR	Discovery agent	N.A.	Investigative	[2]
tannic acid	DM52WGH	Discovery agent	N.A.	Investigative	[2]
Ins(3,4,5,6)P4	DMAQU71	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Volume regulated chloride channel (VRAC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[4]
DIDS	DMKSQUB	Discovery agent	N.A.	Investigative	[4]
GTPgammaS	DMJUXKY	Discovery agent	N.A.	Investigative	[4]
1,9-dideoxyforskolin	DMW613U	Discovery agent	N.A.	Investigative	[4]
diBA-(5)-C4	DM9KPHZ	Discovery agent	N.A.	Investigative	[4]
IAA-94	DMFSAK3	Discovery agent	N.A.	Investigative	[4]
DCPIB	DM9NMIY	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Targeting Chloride channel protein 1 (ClC-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
S-(-)CPP	DME9QR0	Discovery agent	N.A.	Investigative	[3]
S-(-)CPB	DMXUBIK	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[9]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[10]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[11]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[12]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[13]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[14]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
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Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivacaftor	DMZC1HS	Cystic fibrosis	CA25	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Miglustat	DM5J64S	Niemann-Pick disease type C		Approved	[23]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[24]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[21]
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[25]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
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⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium-dependent chloride channel anoctamin (ANO)	TTOJI4S	ANO1_HUMAN	Blocker (channel blocker)	[2]
Chloride channel protein 1 (ClC-1)	TTUYAF3	CLCN1_HUMAN	Blocker (channel blocker)	[3]
Volume regulated chloride channel (VRAC)	TT0FC1V	NOUNIPROTAC	Blocker (channel blocker)	[4]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[5]
Cystic fibrosis transmembrane conductance regulator (CFTR)	OT6B22QH	CFTR_HUMAN	Gene/Protein Processing	[6]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4113).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 698).
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710).
5	Interaction of anthracene and its oxidative derivatives with human serum albumin. Acta Biochim Pol. 2006;53(1):101-12. Epub 2006 Jan 9.
6	Direct effects of 9-anthracene compounds on cystic fibrosis transmembrane conductance regulator gating. Pflugers Arch. 2004 Oct;449(1):88-95. doi: 10.1007/s00424-004-1317-y.
7	Anoctamin Channels in Human Myometrium: A Novel Target for Tocolysis.Reprod Sci. 2018 Nov;25(11):1589-1600.
8	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
9	Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
10	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
11	A protein-coated magnetic beads as a tool for the rapid drug-protein binding study. J Pharm Biomed Anal. 2010 Jul 8;52(3):420-4. doi: 10.1016/j.jpba.2009.06.023. Epub 2009 Jun 18.
12	The three recombinant domains of human serum albumin. Structural characterization and ligand binding properties. J Biol Chem. 1999 Oct 8;274(41):29303-10. doi: 10.1074/jbc.274.41.29303.
13	Exploring binding properties of sertraline with human serum albumin: Combination of spectroscopic and molecular modeling studies. Chem Biol Interact. 2015 Dec 5;242:235-46. doi: 10.1016/j.cbi.2015.10.006. Epub 2015 Oct 22.
14	Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
15	Use of peak decay analysis and affinity microcolumns containing silica monoliths for rapid determination of drug-protein dissociation rates. J Chromatogr A. 2011 Apr 15;1218(15):2072-8. doi: 10.1016/j.chroma.2010.09.070. Epub 2010 Oct 16.
16	[Colchicine in chronic liver disease of alcoholic etiology. Double-blind, randomized study of its effects on blood levels of plasma proteins and clinical course in patients]. Rev Assoc Med Bras (1992). 1995 May-Jun;41(3):207-12.
17	Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7.
18	Covalent binding of the flavonoid quercetin to human serum albumin. J Agric Food Chem. 2005 May 18;53(10):4194-7. doi: 10.1021/jf050061m.
19	Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation. N Engl J Med. 2010 Nov 18;363(21):1991-2003. doi: 10.1056/NEJMoa0909825.
20	Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
21	Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells. Am J Respir Cell Mol Biol. 2003 Sep;29(3 Pt 1):410-8. doi: 10.1165/rcmb.2002-0247OC. Epub 2003 Apr 24.
22	Modulation of deltaF508 cystic fibrosis transmembrane regulator trafficking and function with 4-phenylbutyrate and flavonoids. Am J Respir Cell Mol Biol. 2004 Sep;31(3):351-7. doi: 10.1165/rcmb.2002-0086OC. Epub 2004 Jun 10.
23	Proteasome-dependent pharmacological rescue of cystic fibrosis transmembrane conductance regulator revealed by mutation of glycine 622. J Pharmacol Exp Ther. 2008 Apr;325(1):89-99. doi: 10.1124/jpet.107.134502. Epub 2008 Jan 29.
24	Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004. J Membr Biol. 2003 Jul 15;194(2):109-17. doi: 10.1007/s00232-003-2030-z.
25	Reversible silencing of CFTR chloride channels by glutathionylation. J Gen Physiol. 2005 Feb;125(2):127-41. doi: 10.1085/jgp.200409115. Epub 2005 Jan 18.
26	Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.