Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKN345)

• Drug Name: Charybdotoxin Drug Info
• Synonyms: ChTX; CTX Toxin; Quinquestriatus Toxin; Charybdotoxin (reduced); Toxin, CTX; Toxin, Quinquestriatus

Indication

Disease Entry	ICD 11	Status	REF
Scorpion envenoming syndrome	8D43	Approved	[1]

• Cross-matching ID:
  PubChem CID: 56842037
  CAS Number: CAS 95751-30-7
  TTD Drug ID: DMKN345

Molecule-Related Drug Atlas

Drug(s) Targeting Calcium-activated potassium channel (KCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlorzoxazone	DMCYVDT	Acute pain	MG31	Approved	[4]
ICA-17043	DMRFY7I	Alzheimer disease	8A20	Phase 2	[5]
4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one	DMKMH5L	Discovery agent	N.A.	Investigative	[6]
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	DMQEJVU	Conjunctival fibrosis	9A61.3	Investigative	[6]
4-fluorophenyl-2,2-diphenylacetamide	DMI03KV	Discovery agent	N.A.	Investigative	[5]
N-methyl-2,2,2-triphenylacetamide	DMQGRMO	Discovery agent	N.A.	Investigative	[5]
TRIPHENYLMETHANAMINE	DM3CQIZ	Discovery agent	N.A.	Investigative	[5]
N,N-dimethyl-2,2,2-triphenylacetamide	DM9XZJN	Discovery agent	N.A.	Investigative	[5]
(2-fluorophenyl)-(4-fluorophenyl)phenylacetamide	DMFV76H	Discovery agent	N.A.	Investigative	[5]
2,2,2-tris-(3-fluorophenyl)-acetamide	DMJXAF7	Discovery agent	N.A.	Investigative	[5]

Drug(s) Affected By Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Chlorzoxazone	DMCYVDT	Acute pain	MG31	Approved	[8]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Clotrimazole	DMMFCIH	Cutaneous candidiasis	1F23.14	Approved	[8]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[10]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[13]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[14]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[15]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium-activated potassium channel (KCN)	TTMNI76	NOUNIPROTAC	Blocker	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)	OTQKQ346	KCNN4_HUMAN	Gene/Protein Processing	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2328).
• [2] Reversible inhibition of the platelet procoagulant response through manipulation of the Gardos channel. Blood. 2006 Oct 1;108(7):2223-8.
• [3] 4-Chlorobenzo[F]isoquinoline (CBIQ), a novel activator of CFTR and DeltaF508 CFTR. Eur J Pharmacol. 2005 Jun 1;516(2):118-24. doi: 10.1016/j.ejphar.2005.04.037.
• [4] Chlorzoxazone inhibits contraction of rat thoracic aorta. Eur J Pharmacol. 2006 Sep 18;545(2-3):161-6.
• [5] Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82.
• [6] Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2299-304.
• [7] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [8] Functional and molecular identification of intermediate-conductance Ca(2+)-activated K(+) channels in breast cancer cells: association with cell cycle progression. Am J Physiol Cell Physiol. 2004 Jul;287(1):C125-34. doi: 10.1152/ajpcell.00488.2003. Epub 2004 Feb 25.
• [9] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [10] Decitabine up-regulates S100A2 expression and synergizes with IFN-gamma to kill uveal melanoma cells. Clin Cancer Res. 2007 Sep 1;13(17):5219-25. doi: 10.1158/1078-0432.CCR-07-0816.
• [11] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [12] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [13] Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
• [14] A novel long noncoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer. Toxicol Appl Pharmacol. 2015 Jun 1;285(2):79-88.
• [15] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.