Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMI84K)

• Drug Name: Beta-Lapachone Drug Info
• Synonyms: ARQ 501; SL 11001; A-lapachone; LAPACHONE, BETA; AK-693/21096016; 2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione; 3,4-Dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione; 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-B]pyran-5,6-dione

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 3885
  ChEBI ID: CHEBI:10429
  CAS Number: CAS 4707-32-8
  TTD Drug ID: DMMI84K
  INTEDE Drug ID: DR1869

Molecule-Related Drug Atlas

Drug(s) Targeting DNA topoisomerase I (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[5]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[5]
B-Lactams	DMR8YD6	Bacterial infection	1A00-1C4Z	Approved	[6]
Belotecan hydrocholoride	DM3SRJZ	Small-cell lung cancer	2C25.Y	Approved	[7]
Topetecan	DMAE6LK	Small-cell lung cancer	2C25.Y	Approved	[8]
Karenitecin	DMCRGY4	Lung cancer	2C25.0	Phase 3	[9]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]
Exatecan	DMCA7FN	Solid tumour/cancer	2A00-2F9Z	Phase 3	[11]
Edotecarin	DM3ZL7D	Gastric adenocarcinoma	2B72	Phase 3	[12]
Rubitecan	DMDWU1S	Human immunodeficiency virus infection	1C62	Phase 3	[13]

Drug(s) Metabolized By Quinone reductase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[15]
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[15]
CB1954	DMVP4YK	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[16]
Nitrobenzanthrone	DMN6L70	N. A.	N. A.	Investigative	[17]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[22]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[23]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[24]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[25]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[27]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[36]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[37]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[43]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[45]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase I (TOP1)	TTGTQHC	TOP1_HUMAN	Modulator	[1]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Quinone reductase 1 (NQO1) Main DME	DENP5RY	NQO1_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Drug Response	[3]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Biotransformations	[4]
Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)	OTVT4YA1	ATG7_HUMAN	Drug Response	[3]

References

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