Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNGW1A)

• Drug Name: 2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile Drug Info
• Synonyms: CHEMBL305128

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 14537253
  TTD Drug ID: DMNGW1A

Molecule-Related Drug Atlas

Drug(s) Targeting Protein kinase C epsilon (PRKCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meprobamate	DMHM93Y	Anxiety		Approved	[2]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[3]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[4]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
CDE-6960	DMA0DKI	Inflammation	1A00-CA43.1	Terminated	[6]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione	DMDO175	Discovery agent	N.A.	Investigative	[8]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[8]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[8]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Protein kinase C alpha (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[9]
Sotrastaurin acetate	DME53YS	Renal transplantation	NE84	Phase 2	[10]
PMID28460551-Compound-3	DMA1FRM	N. A.	N. A.	Patented	[11]
ISIS 3521	DMZFS69	N. A.	N. A.	Discontinued in Phase 2	[12]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[13]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[4]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
Acteoside	DM0YHKB	Nephritis	GB40	Terminated	[14]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[15]

Drug(s) Targeting Protein kinase C theta (PRKCQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sotrastaurin acetate	DME53YS	Renal transplantation	NE84	Phase 2	[10]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[4]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
CDE-6960	DMA0DKI	Inflammation	1A00-CA43.1	Terminated	[6]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[16]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[17]
[2,2':5',2'']Terthiophen-4-yl-methanol	DMRQC1F	Discovery agent	N.A.	Investigative	[18]
4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol	DM8IYG1	Discovery agent	N.A.	Investigative	[1]
[2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde	DMWDNLI	Discovery agent	N.A.	Investigative	[18]

Drug(s) Targeting Protein kinase C beta (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[19]
RUBOXISTAURIN HYDROCHLORIDE	DMQOCD8	Lymphoma	2A80-2A86	Phase 3	[20]
Sotrastaurin acetate	DME53YS	Renal transplantation	NE84	Phase 2	[10]
LY333531	DMGMC8H	Solid tumour/cancer	2A00-2F9Z	Phase 2	[21]
MS-553	DM7ER9J	Chronic lymphocytic leukaemia	2A82.0	Phase 1	[22]
Linetastine	DMF8B62	Rhinitis	FA20	Discontinued in Phase 2	[23]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[13]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[4]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]

Drug(s) Targeting Protein kinase C delta (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KAI-9803	DMELJDI	Acute myocardial infarction	BA41	Phase 1/2	[24]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[4]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
AD 198	DMJFY2I	N. A.	N. A.	Terminated	[25]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[16]
PROSTRATIN	DM1HMJ5	Human immunodeficiency virus infection	1C62	Investigative	[26]
[2,2':5',2'']Terthiophen-4-yl-methanol	DMRQC1F	Discovery agent	N.A.	Investigative	[18]
4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol	DM8IYG1	Discovery agent	N.A.	Investigative	[1]
[2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde	DMWDNLI	Discovery agent	N.A.	Investigative	[18]

Drug(s) Targeting Protein kinase C gamma (PRKCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[27]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[13]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[4]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[28]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione	DMDO175	Discovery agent	N.A.	Investigative	[8]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[8]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[8]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Protein kinase C zeta (PRKCZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methyl 2-amino-4-phenylthiophene-3-carboxylate	DM9BYJ0	N. A.	N. A.	Patented	[29]
Y-9680	DMHAVYS	N. A.	N. A.	Patented	[29]
US8889696, 39	DMKXRJ4	N. A.	N. A.	Patented	[30]
US8889672, 252-036-001	DM8B1Q4	N. A.	N. A.	Patented	[29]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[4]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[31]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[16]
[2,2':5',2'']Terthiophen-4-yl-methanol	DMRQC1F	Discovery agent	N.A.	Investigative	[18]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Protein kinase C alpha (PRKCA)	TTFJ8Q1	KPCA_HUMAN	Inhibitor	[1]
Protein kinase C beta (PRKCB)	TTYPXQF	KPCB_HUMAN	Inhibitor	[1]
Protein kinase C delta (PRKCD)	TT9WJ8U	KPCD_HUMAN	Inhibitor	[1]
Protein kinase C epsilon (PRKCE)	TTBZ7OD	KPCE_HUMAN	Inhibitor	[1]
Protein kinase C gamma (PRKCG)	TTRFOXJ	KPCG_HUMAN	Inhibitor	[1]
Protein kinase C theta (PRKCQ)	TT8QL1J	KPCT_HUMAN	Inhibitor	[1]
Protein kinase C zeta (PRKCZ)	TTUWGRA	KPCZ_HUMAN	Inhibitor	[1]

References

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