Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO4GPK)

• Drug Name: Lactose Drug Info
• Synonyms: Aletobiose; D-(+)-Lactose; D-Lactose; Fast-flo; Fast-flo Lactose; Galactinum; Lactin; Lactobiose; Lactose; Lactose [JAN]; Lactose anhydrous; Lactosum anhydricum; Milk sugar; Pharmatose 450M; Saccharum lactin; beta-D-Lactose; beta-Lactose; (+)-Lactose; .beta.-Lactose; 4-(beta-D-Galactosido)-D-glucose; 4-O-beta-D-Galactopyranosyl-D-glucose; 4-O-beta-D-Galactopyranosyl-beta-D-glucopyranose; 5965-66-2; D-Glucose, 4-O-beta-D-galactopyranosyl; EINECS 227-751-9; UNII-13Q3A43E0S; beta-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6134
  ChEBI ID: CHEBI:36218
  CAS Number: CAS 5965-66-2
  TTD Drug ID: DMO4GPK
  INTEDE Drug ID: DR2807

Molecule-Related Drug Atlas

Drug(s) Targeting Influenza Neuraminidase (Influ NA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oseltamivir	DMGO72P	Influenza	1E30-1E32	Approved	[4]
Zanamivir	DMFMBZ4	Influenza	1E30-1E32	Approved	[4]
Peramivir	DMNXY5K	Influenza virus infection	1E30-1E32	Approved	[5]
UX-001	DMD2O0L	Hereditary inclusion body myositis	4A41.2	Phase 3	[1]
CS-8958	DM4CSDH	Influenza virus infection	1E30-1E32	Phase 3	[5]
DAS-181	DM0Y8JP	Influenza virus infection	1E30-1E32	Phase 2	[6]
GS-3435	DMV7JC6	Influenza virus infection	1E30-1E32	Terminated	[7]
BCX-140	DMBJERO	Influenza virus infection	1E30-1E32	Terminated	[8]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[1]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[1]

Drug(s) Metabolized By Cellobiose 2-epimerase (CE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[3]
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[3]
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[3]
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[3]
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[3]

Drug(s) Metabolized By Beta-galactosidase (bgaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PNA-D-glucopyranoside	DMPUC8I	N. A.	N. A.	Investigative	[2]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Influenza Neuraminidase (Influ NA)	TT50QJ3	NRAM_I33A0	Inhibitor	[1]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-galactosidase (bgaB)	DEQB4LT	A0A2U1B4D0_9BACT	Substrate	[2]
Cellobiose 2-epimerase (CE)	DEGLW18	A0A173SS24_9FIRM	Substrate	[3]
Cellobiose 2-epimerase (CE)	DENTGJO	A0A173Z970_9FIRM	Substrate	[3]
Cellobiose 2-epimerase (CE)	DE4XLDR	A0A174ZCD1_9FIRM	Substrate	[3]
Cellobiose 2-epimerase (CE)	DEGBVKJ	A9KK53_LACP7	Substrate	[3]
Cellobiose 2-epimerase (CE)	DEDY9F6	CEEP_EUBCE	Substrate	[3]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] Identification and characterization of a novel beta-galactosidase from Victivallis vadensis ATCC BAA-548, an anaerobic fecal bacterium. J Microbiol. 2012 Dec;50(6):1034-40.
• [3] Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40.
• [4] Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102.
• [5] Developing new antiviral agents for influenza treatment: what does the future hold Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13.
• [6] Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein. PLoS One. 2009 Nov 6;4(11):e7838.
• [7] US patent application no. 2010,0081,713, Compositions and methods for treating viral infections.
• [8] CN patent application no. 104447481, Benzoic acid thiourea anti-influenza virus compounds as well as preparation method and use thereof.