Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS3AXK)

• Drug Name: EDMT Drug Info
• Synonyms: 2-Ethyl-5-methoxy-N,N-dimethyltryptamine; EMDT; 2-ethyl-5-methoxy-N,N-dimethyltryptamine; CHEMBL267615; 2-(2-ethyl-5-methoxy-1H-indol-3-yl)-N,N-dimethylethanamine; AC1OCFIZ; GTPL12; SCHEMBL2537573; BDBM34142; ZINC13805803; PDSP1_001417; PDSP2_001401; AKOS027422828; NCGC00387149-01; N,N-Dimethyl-2-ethyl-5-methoxy-1H-indole-3-ethanamine; [2-(2-ethyl-5-methoxy-1H-indol-3-yl)ethyl]dimethylamine,

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1] , [2]

• Cross-matching ID:
  PubChem CID: 6918513
  TTD Drug ID: DMS3AXK

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT 1D receptor (HTR1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[4]
Eletriptan	DMW649X	Migraine	8A80	Approved	[5]
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[5]
Frovatriptan	DM7RE8P	Migraine	8A80	Approved	[5]
Sumatriptan	DMVYXR8	Migraine	8A80	Approved	[6]
Rizatriptan	DMDJMA3	Migraine	8A80	Approved	[7]
Almogran	DM7I64Z	Migraine	8A80	Approved	[8]
Neu-P11	DMIQDFW	Alzheimer disease	8A20	Phase 2	[9]
FKB01MD	DM2O7NM	N. A.	N. A.	Phase 2	[10]
NXN-188	DMMBAIH	Migraine	8A80	Phase 2	[11]

Drug(s) Targeting 5-HT 5A receptor (HTR5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[12]
(+/-)-nantenine	DM0L3GE	Discovery agent	N.A.	Investigative	[13]
Serotonin	DMOFCRY	Discovery agent	N.A.	Investigative	[14]
5-CT	DM260KD	Discovery agent	N.A.	Investigative	[15]
TFMPP	DMAC8TP	Discovery agent	N.A.	Investigative	[16]
5,6-dichloro-3,4-dihydroquinazolin-2-amine	DMN1S35	Discovery agent	N.A.	Investigative	[17]
MPDT	DMYX31S	Discovery agent	N.A.	Investigative	[3]
5-chloro-3,4-dihydroquinazolin-2-amine	DMKEFJ0	Discovery agent	N.A.	Investigative	[17]
5-chloro-4-methyl-3,4-dihydroquinazolin-2-amine	DM7FZU2	Discovery agent	N.A.	Investigative	[17]
[3H]5-CT	DMEAHFZ	Discovery agent	N.A.	Investigative	[18]

Drug(s) Targeting 5-HT 6 receptor (HTR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LU AE58054	DMWGRQD	Schizophrenia	6A20	Phase 3	[19]
SB-742457	DM6L4ZT	Alzheimer disease	8A20	Phase 3	[20]
AVN 211	DMVB4OS	Schizophrenia	6A20	Phase 2/3	[21]
SYN120	DMDF7XB	Parkinson disease	8A00.0	Phase 2	[22]
AVN 101	DMJFLBC	Alzheimer disease	8A20	Phase 2	[21]
SYN-120	DMPW0UL	Alzheimer disease	8A20	Phase 2	[23]
PF-05212377	DMPVQYR	Alzheimer disease	8A20	Phase 2	[24]
AVN 322	DMK2LGM	Cognitive impairment	6D71	Phase 2	[20]
SAM-531	DMHVJZ6	Alzheimer disease	8A20	Phase 2	[25]
SUVN-502	DMQD753	Alzheimer disease	8A20	Phase 2	[26]

Drug(s) Targeting 5-HT 1A receptor (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[5]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[27]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[28]
Vilazodone	DM4LECQ	Major depressive disorder	6A70.3	Approved	[29]
Flibanserin	DM70DTN	Mood disorder	6A60-6E23	Approved	[30]
Tertatolol	DM2L3D5	Hypertension	BA00-BA04	Approved	[31]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[32]
Treximet	DMU54QB	Migraine	8A80	Approved	[33]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[34]
Eltoprazine	DMW6C81	Attention deficit hyperactivity disorder	6A05.Z	Phase 3	[35]

Drug(s) Targeting 5-HT 7 receptor (HTR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[10]
JNJ-18038683	DMV1T59	Major depressive disorder	6A70.3	Phase 2	[36]
AVN-101	DMOGFNI	Cognitive impairment	6D71	Phase 2	[37]
ATI-9242	DM6GKMU	Schizophrenia	6A20	Phase 1	[38]
PMID30124346-Compound-34TABLE4	DM2G3VE	Attention deficit hyperactivity disorder	6A05.Z	Patented	[39]
PMID30124346-Compound-13TABLE4	DMHTJVA	Attention deficit hyperactivity disorder	6A05.Z	Patented	[39]
Carbamide derivative 2	DMW5GI3	N. A.	N. A.	Patented	[40]
4-oxadiazole derivative 1	DMWFHKR	N. A.	N. A.	Patented	[40]
SB-269970	DM8WTGA	Sleep-wake disorder	7A00-7B2Z	Terminated	[41]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one	DMM9X0G	Discovery agent	N.A.	Investigative	[42]

Drug(s) Targeting 5-HT 1E receptor (HTR1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[43]
5-CT	DM260KD	Discovery agent	N.A.	Investigative	[43]
TFMPP	DMAC8TP	Discovery agent	N.A.	Investigative	[43]
1-naphthylpiperazine	DM6BIWK	Discovery agent	N.A.	Investigative	[43]
BRL-15572	DMM61Y2	Discovery agent	N.A.	Investigative	[44]
2-methyl-5-HT	DM1S5CB	N. A.	N. A.	Investigative	[45]
alpha-methyl-5-HT	DMCAYXF	Discovery agent	N.A.	Investigative	[43]
m-chlorophenylpiperazine	DMM1J2D	Discovery agent	N.A.	Investigative	[43]
9-OH-risperidone	DMGORXQ	Discovery agent	N.A.	Investigative	[46]
[3H]5-HT	DMYJXV7	Discovery agent	N.A.	Investigative	[47]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Agonist	[3]
5-HT 1D receptor (HTR1D)	TT6MSOK	5HT1D_HUMAN	Agonist	[3]
5-HT 1E receptor (HTR1E)	TTCPG9S	5HT1E_HUMAN	Agonist	[3]
5-HT 5A receptor (HTR5A)	TTRUFDT	5HT5A_HUMAN	Agonist	[3]
5-HT 6 receptor (HTR6)	TTJS8PY	5HT6R_HUMAN	Inhibitor	[3] , [2]
5-HT 7 receptor (HTR7)	TTO9X1H	5HT7R_HUMAN	Agonist	[3]

References

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