Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUMQZ0)

• Drug Name: Clidinium Drug Info
• Synonyms: clidinium; N-Methyl quinuclidinyl benzilate; 7020-55-5; 3-hydroxy-1-methylquinuclidinium benzilate ester; 3-{[hydroxy(diphenyl)acetyl]oxy}-1-methyl-1-azoniabicyclo[222]octane; Ro-23773; 3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-methyl-1-azonia-bicyclo[222]octane; 1-Azoniabicyclo(222)octane, 3-((hydroxydiphenylacetyl)oxy)-1-methyl-; [3H]clidinium; (-)MQNB; Clidinium bromid; (1-methyl-1-azoniabicyclo[222]octan-8-yl) 2-hydroxy-2,2-di(phenyl)acetate; 3-Hydroxy-1-methylquinuclidinium benzilate (ester); Quinuclidinium,; Librax (TN); Benzilic acid, ester with 3-hydroxy-1-methylquinuclidinium; Quinuclidinium, 3-hydroxy-1-methyl-, benzilate (ester); (1-methyl-1-azoniabicyclo[222]octan-3-yl) 2-hydroxy-2,2-diphenylacetate

Indication

Disease Entry	ICD 11	Status	REF
Abdominal stomach pain	DD91.4	Approved	[1] , [2] , [3]
Irritable bowel syndrome	DD91.0	Approved	[1] , [2] , [3]

• Therapeutic Class: Analgesics
• Cross-matching ID:
  PubChem CID: 2784
  ChEBI ID: CHEBI:3743
  CAS Number: CAS 7020-55-5
  TTD Drug ID: DMUMQZ0
  VARIDT Drug ID: DR01421

Molecule-Related Drug Atlas

Drug(s) Transported By Organic cation transporter 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[7]
Cisplatin	DMRHGI9	Solid tumour/cancer	2A00-2F9Z	Approved	[8]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[9]
Oxaliplatin	DMQNWRD	Colorectal cancer	2B91.Z	Approved	[10]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[11]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[12]
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[13]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[14]
Dopamine	DMPGUCF	Parkinson disease	8A00.0	Approved	[15]
Propranolol	DM79NTF	Migraine	8A80	Approved	[16]

Drug(s) Targeting Muscarinic acetylcholine receptor (CHRM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[17]
Tiotropium	DMFDC0Q	Chronic obstructive pulmonary disease	CA22	Approved	[18]
Darifenacin	DMWXLYZ	Overactive bladder	GC50.0	Approved	[19]
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[20]
Oxybutynin hydrochloride	DMF2KLU	Urinary incontinence	MF50.2	Approved	[21]
Incruse ellipta	DM32GSJ	Chronic obstructive pulmonary disease	CA22	Approved	[22]
Revefenacin	DMMP5SI	Chronic obstructive pulmonary disease	CA22	Approved	[23]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[24]
Isopropamide iodide	DMQYV60	Allergic rhinitis	CA08.0	Approved	[25]
SUN-101	DMXNZQK	Chronic obstructive pulmonary disease	CA22	Phase 3	[26]

Drug(s) Targeting Muscarinic acetylcholine receptor M1 (CHRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[27]
Fesoterodine fumarate	DM13495	Overactive bladder	GC50.0	Approved	[3]
SMT-D002	DM1I93C	Seborrhea	ED91.2	Approved	[28]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[29]
Oxyphenonium	DMMQHOZ	Visceral spasms	MD81.4	Approved	[30]
Benztropine	DMGZOVN	Parkinson disease	8A00.0	Approved	[31]
Glycopyrrolate	DM2M3ZA	Anaesthesia	9A78.6	Approved	[32]
Pirenzepine	DMP6M1N	Peptic ulcer	DA61	Approved	[33]
Cycrimine	DM8C43Q	Parkinson disease	8A00.0	Approved	[34]
Dicyclomine	DMZSDGX	Functional bowel syndrome	DD91.0	Approved	[35]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor (CHRM)	TTOXS3C	NOUNIPROTAC	Antagonist	[4]
Muscarinic acetylcholine receptor M1 (CHRM1)	TTZ9SOR	ACM1_HUMAN	Antagonist	[5]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[6]

References

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• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
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• [16] Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145.
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• [18] Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. J Pharmacol Exp Ther. 2013 May;345(2):260-70.
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• [21] Effects of propiverine hydrochloride (propiverine) on the muscarinic receptor binding affinity in guinea pig tissues and on salivation in conscious dogs. Nihon Yakurigaku Zasshi. 1999 Mar;113(3):157-66.
• [22] Clinical pipeline report, company report or official report of GlaxoSmithKline.
• [23] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [24] The amygdala modulates morphine-induced state-dependent memory retrieval via muscarinic acetylcholine receptors. Neuroscience. 2009 May 5;160(2):255-63.
• [25] Competitive and non-competitive antagonism exhibited by 'selective' antagonists at atrial and ileal muscarinic receptor subtypes. Br J Pharmacol. 1987 Apr;90(4):701-7.
• [26] Long-acting bronchodilators in COPD: Where are we now and where are we going Breathe 06/2014; 10(2):110-120.
• [27] Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7.
• [28] Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder. J Urol. 2004 Nov;172(5 Pt 1):2059-64.
• [29] The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic dr... Psychopharmacology (Berl). 2009 Apr;203(2):295-301.
• [30] Ultraviolet spectroscopic estimation of microenvironments and bitter tastes of oxyphenonium bromide in cyclodextrin solutions. J Pharm Sci. 1999 Aug;88(8):759-62.
• [31] Formulation and biopharmaceutical evaluation of transdermal patch containing benztropine. Int J Pharm. 2008 Jun 5;357(1-2):55-60.
• [32] Autonomic cardiovascular control during a novel pharmacologic alternative to ganglionic blockade. Clin Pharmacol Ther. 2008 May;83(5):692-701.
• [33] Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate. Neurosci Lett. 2009 Aug 14;459(3):127-31.
• [34] Capillary gas chromatography of trihexyphenidyl, procyclidine and cycrimine in biological fluids. J Chromatogr. 1989 Sep 29;494:135-42.
• [35] [Characterization of muscarinic receptors in undifferentiated thyroid cells in Fisher rats]. Endocrinol Nutr. 2009 Mar;56(3):106-11.