Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVYSLE)

• Drug Name: Cefalotin Drug Info
• Synonyms: Cefalothin; Cefalotina; Cefalotine; Cefalotinum; Cemastin; Cephalothinum; Cephalotin; Coaxin; Cefalotina fabra; Cephalothin Monosodium Salt; Averon-1; Cefalotin (BAN); Cefalotina [INN-Spanish]; Cefalotina fabra (TN); Cefalotine [INN-French]; Cefalotinum [INN-Latin]; Keflin (TN); (6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 3-(Acetoxymethyl)-8-oxo-7-(2-(2-thienyl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid; 3-(Hydroxymethyl)-8-oxo-7-(2-(2-thienyl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid acetate; 3-ACETOXYMETHYL-8-OXO-7-(2-THIOPHEN-2-YL-ACETYLAMINO)-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID; 3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-(2-(2-thienyl)acetamido)-, acetate (ester); 6R-trans-3-((Acetyloxy)methyl)-8-oxo-7-((2-thienylacetyl)amino)-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-carboxylic acid; 7-(2-(2-Thienyl)acetylamido)cephalosporanic acid; 7-(2-Thienylacetamido)cephalosporanic acid; 7-(Thiophene-2-acetamido)cephalosporanic acid; 7-(Thiophene-2-acetamido)cephalosporin; 7beta-(thiophen-2-ylacetamido)-3-acetoxymethyl-3,4-didehydrocepham-4-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Bacteremia	1A73	Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Pneumonia	CA40	Approved	[3]
Urinary tract infection	GC08	Approved	[4]

• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 6024
  ChEBI ID: CHEBI:124991
  CAS Number: CAS 153-61-7
  TTD Drug ID: DMVYSLE
  INTEDE Drug ID: DR2178

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial DD-carboxypeptidase (Bact vanYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
B-Lactams	DMR8YD6	Bacterial infection	1A00-1C4Z	Approved	[10]
Cephalosporin	DM79XDW	Bacterial infection	1A00-1C4Z	Approved	[11]
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[12]
TD-1792	DMGKBZH	Skin infection	1F28-1G0Z	Phase 3	[13]
Phenyl Boronic acid	DMFZH49	Discovery agent	N.A.	Investigative	[14]
Cephalosporin C	DMYW3ZG	Discovery agent	N.A.	Investigative	[15]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[16]
D-Alanine	DMVIDQL	Discovery agent	N.A.	Investigative	[16]
3-boronobenzoic acid	DMRCJW0	Discovery agent	N.A.	Investigative	[14]
NITROCEFIN	DM7M5VY	Discovery agent	N.A.	Investigative	[17]

Drug(s) Metabolized By Beta-lactamase (blaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[18]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[6]
Piperacillin	DMTBKF3	Acute gonococcal cervicitis		Approved	[6]
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[6]
Cephaloridine	DM4Y95F	Gram-positive bacterial infection	1B74-1G40	Withdrawn from market	[6]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[18]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[18]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[18]
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[19]

Drug(s) Metabolized By AmpC beta-lactamase (ampC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[8]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[8]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[24]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[25]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[26]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[28]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[29]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[30]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[31]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[33]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[34]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[35]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[38]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[39]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial DD-carboxypeptidase (Bact vanYB)	TTLP6GN	VANY_ENTFA	Inhibitor	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-lactamase (blaB)	DET9I1W	BLAC_BACUN	Substrate	[6]
Beta-lactamase (blaB)	DENJ2SQ	BLAB_BACFG	Substrate	[7]
AmpC beta-lactamase (ampC)	DERI7LO	A0A0H3KQ39_BURM1	Substrate	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[9]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[9]

References

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