Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXZU73)

• Drug Name: Carbapenem Drug Info
• Synonyms: Carbapenem; Cis-carbapenem; (5R)-1-azabicyclo[3.2.0]hept-2-en-7-one; 2,3-didehydro-1-carbapenam; 67836-EP2275424A1; 67836-EP2295402A2; 67836-EP2305219A1; 67836-EP2308874A1; CHEBI:46765; SCHEMBL37243
• Cross-matching ID:
  PubChem CID: 13293131
  ChEBI ID: CHEBI:46765
  TTD Drug ID: DMXZU73
  INTEDE Drug ID: DR2678

Molecule-Related Drug Atlas

Drug(s) Metabolized By Beta-lactamase (blaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cephalosporin	DM79XDW	Bacterial infection	1A00-1C4Z	Approved	[2]
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[2]
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[4]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[5]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[5]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[4]
Ceftazidine	DMPZTRC	N. A.	N. A.	Phase 4	[5]

Drug(s) Affected By Acylamino-acid-releasing enzyme (APEH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[6]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[12]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[14]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[15]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-lactamase (blaB)	DEBKS91	A0A1B1FBM9_ACIBA	Substrate	[1]
Beta-lactamase (blaB)	DESIWFO	Q8GQK7_9FLAO	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acylamino-acid-releasing enzyme (APEH)	OTX258QE	ACPH_HUMAN	Gene/Protein Processing	[3]

References

• [1] Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil. Rev Soc Bras Med Trop. 2019 Dec 20;53:e20190044.
• [2] EBR-1, a novel Ambler subclass B1 beta-lactamase from Empedobacter brevis. Antimicrob Agents Chemother. 2002 Oct;46(10):3223-7.
• [3] Identification of valproic acid glucuronide hydrolase as a key enzyme for the interaction of valproic acid with carbapenem antibiotics. Drug Metab Dispos. 2010 Sep;38(9):1538-44. doi: 10.1124/dmd.110.032938. Epub 2010 Jun 15.
• [4] A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit. PLoS One. 2018 Dec 28;13(12):e0209367.
• [5] Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection. Chin Med J (Engl). 2010 Sep;123(18):2571-5.
• [6] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [7] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [8] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [9] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [10] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [11] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [12] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [13] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [14] Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006 Oct 20;1116(1):39-49.
• [15] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.