Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXZU73)

Drug Name

Carbapenem Drug Info

Synonyms

Carbapenem; Cis-carbapenem; (5R)-1-azabicyclo[3.2.0]hept-2-en-7-one; 2,3-didehydro-1-carbapenam; 67836-EP2275424A1; 67836-EP2295402A2; 67836-EP2305219A1; 67836-EP2308874A1; CHEBI:46765; SCHEMBL37243

Indication

Disease Entry	ICD 11	Status	REF
Cystitis	GC00	Phase 4	[1]

Cross-matching ID

PubChem CID: 13293131
ChEBI ID: CHEBI:46765
TTD Drug ID: DMXZU73
INTEDE Drug ID: DR2678

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Metabolized By Beta-lactamase (blaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cephalosporin	DM79XDW	Bacterial infection	1A00-1C4Z	Approved	[3]
Benzylpenicillin	DMS9503	N. A.	N. A.	Phase 3	[3]
Imipenem	DMI9FBP	Bacterial infection	1A00-1C4Z	Approved	[4]
Ampicillin	DMHWE7P	Bacterial infection	1A00-1C4Z	Approved	[5]
Ceftriaxone	DMCEW64	Bacterial infection	1A00-1C4Z	Approved	[5]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[4]
Ceftazidine	DMPZTRC	Meningitis	1D01	Phase 4	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-lactamase (blaB)	DEBKS91	A0A1B1FBM9_ACIBA	Substrate	[2]
Beta-lactamase (blaB)	DESIWFO	Q8GQK7_9FLAO	Substrate	[3]

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References

1	National Center for Advancing Translational Science-Inxight: drug (GL970841YS)
2	Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil. Rev Soc Bras Med Trop. 2019 Dec 20;53:e20190044.
3	EBR-1, a novel Ambler subclass B1 beta-lactamase from Empedobacter brevis. Antimicrob Agents Chemother. 2002 Oct;46(10):3223-7.
4	A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit. PLoS One. 2018 Dec 28;13(12):e0209367.
5	Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection. Chin Med J (Engl). 2010 Sep;123(18):2571-5.