Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZA45C)

• Drug Name: BX-912 Drug Info
• Synonyms: BX 912; BX912

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 11754511
  ChEBI ID: CHEBI:91357
  CAS Number: CAS 702674-56-4
  TTD Drug ID: DMZA45C

Molecule-Related Drug Atlas

Drug(s) Targeting Phosphoinositide dependent protein kinase-1 (PDPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AR-12	DM4RK6P	Lymphoma	2A80-2A86	Phase 1	[3]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[4]
PMID20005102C1	DMMESBW	Discovery agent	N.A.	Investigative	[5]
BX-795	DMRIMLJ	Discovery agent	N.A.	Investigative	[2]
PHT-427	DMI96Y3	Discovery agent	N.A.	Investigative	[6]
PF-5177624	DMUOFT0	Solid tumour/cancer	2A00-2F9Z	Investigative	[7]
GSK-2334470	DM3BI7R	Solid tumour/cancer	2A00-2F9Z	Investigative	[8]

Drug(s) Targeting Checkpoint kinase-1 (CHK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY2603618	DMCXRZF	Pancreatic cancer	2C10	Phase 2	[9]
UCN-01	DMUNJZB	Non-small-cell lung cancer	2C25.Y	Phase 2	[10]
SCH-900776	DM67EMK	Solid tumour/cancer	2A00-2F9Z	Phase 2	[11]
LY2606368	DM4XMF7	Ovarian cancer	2C73	Phase 2	[12]
LY2880070	DMADEHZ	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[13]
RG7741	DMK6P9J	Lymphoma	2A80-2A86	Phase 1	[14]
GDC-0425	DMDZ26X	Lymphoma	2A80-2A86	Phase 1	[15]
AZD7762	DM1FW0C	Solid tumour/cancer	2A00-2F9Z	Phase 1	[16]
MK-8776	DMAS1RB	Hodgkin lymphoma	2B30	Phase 1	[17]
Diamidothiazole derivative 1	DM02V5Q	N. A.	N. A.	Patented	[18]

Drug(s) Targeting Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
R-roscovitine	DMSH108	Non-small-cell lung cancer	2C25.Y	Phase 2	[19]
Ro 31-7453	DM83QCL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[20]
PHA848125	DMS2Q9G	Thymic cancer	2C27	Phase 2	[21]
TG02	DMZFIGQ	Anaplastic astrocytoma	2A00.0	Phase 1/2	[22]
NUV-422	DMQJQNT	Malignant glioma	2A00.0	Phase 1/2	[23]
RGB-286638	DMEGOQP	Haematological malignancy	2B33.Y	Phase 1	[24]
FN-1501	DM7BMD6	Solid tumour/cancer	2A00-2F9Z	Phase 1	[25]
AG-024322	DMY4WVK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]
PHA-793887	DM2Y4FG	Solid tumour/cancer	2A00-2F9Z	Phase 1	[26]
SNS-032	DMEITAS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[27]

Drug(s) Targeting Glycogen synthase kinase-3 beta (GSK-3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMO-02	DMJRU3A	Myotonic dystrophy	8C71.0	Phase 2/3	[28]
LY2090314	DMTBFE4	Acute myeloid leukaemia	2A60	Phase 2	[29]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[30]
Tideglusib	DME4LA1	Alzheimer disease	8A20	Phase 2	[31]
9-ING-41	DM57TY3	Myelofibrosis	2A20.2	Phase 2	[32]
Neu-120	DMXKOUC	Parkinson disease	8A00.0	Phase 1/2	[33]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[34]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[35]
TDZD-8	DMG6Q45	Malignant glioma	2A00.0	Patented	[36]
AR-A014418	DMUPN01	Ovarian cancer	2C73	Patented	[37]

Drug(s) Targeting Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[38]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[39]
Regorafenib	DMHSY1I	Gastrointestinal stromal tumour	2B5B	Approved	[40]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[41]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[42]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[20]
Pazopanib HCl	DM6U9CQ	Renal cell carcinoma	2C90	Approved	[43]
Fruquintinib	DMHOSCQ	Colorectal cancer	2B91.Z	Approved	[44]
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[45]
Tivozanib	DMUKC5L	Renal cell carcinoma	2C90	Approved	[46]

Drug(s) Targeting Fungal Protein kinase A (Fung ypkA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[47]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[48]
Ro-4396686	DM5DMCH	Discovery agent	N.A.	Investigative	[49]
PMID20005102C1	DMMESBW	Discovery agent	N.A.	Investigative	[5]
[3H]cAMP	DMZRQU7	Discovery agent	N.A.	Investigative	[50]
PMID19364658C33	DMSE1C3	Discovery agent	N.A.	Investigative	[51]
BX-795	DMRIMLJ	Discovery agent	N.A.	Investigative	[2]
chelerythrine	DMCP1G9	Discovery agent	N.A.	Investigative	[52]
PMID21742770C1	DME3JMH	Discovery agent	N.A.	Investigative	[53]
Rp-adenosine 3',5'-cyclic monophosphothioate triethylamine (Rp-cAMPS)	DM1JWGH	Discovery agent	N.A.	Investigative	[54]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Checkpoint kinase-1 (CHK1)	TTTU902	CHK1_HUMAN	Inhibitor	[2]
Cyclin-dependent kinase 2 (CDK2)	TT7HF4W	CDK2_HUMAN	Inhibitor	[2]
Fungal Protein kinase A (Fung ypkA)	TTYVI76	Q56921_YEREN	Inhibitor	[2]
Glycogen synthase kinase-3 beta (GSK-3B)	TTRSMW9	GSK3B_HUMAN	Inhibitor	[2]
Phosphoinositide dependent protein kinase-1 (PDPK1)	TT9QBI6	PDPK1_HUMAN	Inhibitor	[2]
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[2]

References

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