Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZFVGC)

• Drug Name: PGH2 Drug Info
• Synonyms: Prostaglandin h2; prostaglandin h2; 9,11-Epoxymethano-pgh2; Endoperoxide H2; Prostaglandin R2; 42935-17-1; UNII-J670X3LRU2; prostaglandin-H2; J670X3LRU2; CHEBI:15554; 9S,11R-epidioxy-15S-hydroxy-5Z,13E-prostadienoic acid; (15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoic acid; 15-Hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid; (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate; (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate; prostaglandin H2; U46609

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 445049
  ChEBI ID: CHEBI:15554
  CAS Number: CAS 42935-17-1
  TTD Drug ID: DMZFVGC

Molecule-Related Drug Atlas

Drug(s) Targeting Thromboxane A2 receptor (TBXA2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alprostadil	DMWH7NQ	Aorta coarctation		Approved	[4]
Ridogrel	DMWH9CN	Acute myocardial infarction	BA41	Approved	[5]
LAROPIPRANT	DM5FABJ	Coronary heart disease	BA80.Z	Phase 4	[6]
Ramatroban	DMB8UQ3	Perennial allergic rhinitis	CA08.03	Phase 2/3	[7]
KP-496	DMCO8UZ	Asthma	CA23	Phase 2	[8]
FK-070	DMJSD5W	Angina pectoris	BA40	Phase 2	[9]
TAK-128	DMHPEFS	Diabetic neuropathy	8C0Z	Phase 2	[10]
Ifetroban sodium	DMZP84Y	Thrombosis	DB61-GB90	Phase 2	[11]
Ifetroban	DMEV39E	Aspirin-induced asthma	CA23.20	Phase 2	[12]
YM-57158	DMS31YW	Allergic rhinitis	CA08.0	Phase 1	[13]

Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[18]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[19]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[20]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[21]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[22]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[23]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[18]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thromboxane A2 receptor (TBXA2R)	TT2O84V	TA2R_HUMAN	Agonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Glutathione S-transferase Mu 2 (GSTM2)	OTG4WT05	GSTM2_HUMAN	Regulation of Drug Effects	[3]
Glutathione S-transferase Mu 3 (GSTM3)	OTLA2WJT	GSTM3_HUMAN	Regulation of Drug Effects	[3]

References

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