Details of the Drug Reposition

General Information of This Drug (ID: DMP6SC2)

• Drug Name: Irinotecan (DMP6SC2)
• Synonyms: Biotecan; Camptosar; Irinotecanum; IRINOTECAN HYDROCHLORIDE Trihydrate; Irinotecan Hcl; Irinotecan hydrochloride; CP0; Biotecan (TN); Campto (TN); Camptosar (TN); Irinotecan (INN); Irinotecan [INN:BAN]; Irinotecanum [INN-Latin]; IRINOTECAN, CPT-11; Camptosar, Campto, CPT-11, Irinotecan; (+)-Irinotecan; (4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE; (4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-9-yl 4-piperidylpiperidinecarboxylate; Irinotecan (TOPO1 inhibitor); Onivyde
• Therapeutic Class: Anticancer Agents
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

13 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Rectum mucinous adenocarcinoma	DIS75WFS	N.A.	Approved	[1]
Rectal neoplasm	DISB4UZ0	N.A.	Approved	[1]
Peritoneal neoplasm	DIS2ZMIF	N.A.	Approved	[1]
Metastasis from malignant tumor of colon	DIS175N9	N.A.	Approved	[1]
Kidney neoplasm	DISBNZTN	N.A.	Approved	[1]
Endocrine gland neoplasm	DISGQU9D	N.A.	Approved	[1]
Colon adenocarcinoma	DISDRE0J	N.A.	Approved	[1]
Brain glioma	DISE8B6O	N.A.	Approved	[1]
Appendiceal neoplasm	DIS2XZ0U	N.A.	Approved	[1]
Astrocytoma	DISL3V18	2A00.0Y	Approved	[1]
Advanced cancer	DISAT1Z9	2A00-2F9Z	Approved	[1]
Rectal adenocarcinoma	DIS8R9VO	2B92	Approved	[1]
Adenocarcinoma	DIS3IHTY	2D40	Approved	[1]

3 Discontinued in Phase 3 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Colorectal adenocarcinoma	DISPQOUB	N.A.	Discontinued in Phase 3	[2]
Ewing sarcoma	DISQYLV3	2B52	Discontinued in Phase 3	[3]
Colorectal cancer	DISNH7P9	2B91.Z	Discontinued in Phase 3	[4]

1 Discontinued in Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Colonic neoplasm	DISSZ04P	N.A.	Discontinued in Phase 2	[5]

2 Discontinued in Phase 1 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Rectal signet ring cell adenocarcinoma	DISORL5H	N.A.	Discontinued in Phase 1	[6]
Colorectal neoplasm	DISR1UCN	N.A.	Discontinued in Phase 1	[7]

6 Investigative Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Colon mucinous adenocarcinoma	DISXZXEI	N.A.	Investigative	[1]
Adult glioblastoma	DISVP4LU	N.A.	Investigative	[1]
Gastric cancer	DISXGOUK	2B72	Investigative	[1]
Colon cancer	DISVC52G	2B90.Z	Investigative	[1]
Neuroblastoma	DISVZBI4	2D11.2	Investigative	[1]
Diarrhea	DISWTJQL	ME05.1	Investigative	[1]

References

• [1] Irinotecan FDA Label
• [2] STATIN-VAP STATIN-VAP - STATINs and Ventilator-Associated Pneumonia
• [3] Study of the Use of Niaspan for Treatment of Dyslipidemia in Diabetic Nephropathy
• [4] Multi-center Study to Evaluate the Efficacy and Safety of Maintenance Therapy With Valrubicin Versus no Maintenance, in Subjects Treated With Valrubicin Induction for Carcinoma in Situ (CIS) of the Bladder
• [5] Treatment of a Cancerous Disease of the Peritoneum With Complete Cytoreductive Surgery and Intraperitoneal Chemohyperthermia
• [6] A Trial of Inflammatory Markers, Depressive Symptoms, and Heart Disease
• [7] A Study of the Safety and Pharmacokinetics of AGS-8M4 Given in Combination With Chemotherapy in Women With Ovarian Cancer