General Information of Disease (ID: DISL3V18)

Disease Name Astrocytoma
Synonyms astrocytoma
Disease Class 2A00: Brain cancer
Definition
A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma.|This class denotes astrocytomas proper which excludes GBM. See https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/23
Disease Hierarchy
DISFADP9: Astrocytic tumor
DISL3V18: Astrocytoma
ICD Code
ICD-11
ICD-11: 2A00.0Y
Disease Identifiers
MONDO ID
MONDO_0019781
MESH ID
D001254
UMLS CUI
C0004114
MedGen ID
438
HPO ID
HP:0009592
SNOMED CT ID
1157043006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 4 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Aminolevulinic acid hci DMS4BLQ Approved Small molecular drug [1]
Dacarbazine DMNPZL4 Approved Small molecular drug [2]
Irinotecan DMP6SC2 Approved Small molecular drug [3]
Temozolomide DMKECZD Approved Small molecular drug [4]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
LB-100 DMC04SR Phase 2 Small molecular drug [5]
TVB-2640 DM19GUH Phase 2 NA [6]
TVI-Brain-1 cancer vaccine DM776EU Phase 2 NA [6]
CC-90010 DMKH3Z9 Phase 1 NA [7]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 159 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ACVR1 TTJNBQA Limited Biomarker [8]
ANGPT1 TTWNQ1T Limited Altered Expression [9]
AOX1 TT3MOS2 Limited Biomarker [10]
ATP2A2 TTE6THL Limited Biomarker [11]
BRAF TT0EOB8 Limited Genetic Variation [12]
CD160 TTOFEAS Limited Altered Expression [13]
FGFR1 TTRLW2X Limited Altered Expression [14]
GDNF TTF23ML Limited Biomarker [15]
IFNB1 TT4TZ8J Limited Biomarker [16]
KCNA5 TTW0CMT Limited Altered Expression [17]
KRAS TTM8FR7 Limited Biomarker [18]
LATS2 TTML7FG Limited Posttranslational Modification [19]
MET TTNDSF4 Limited Biomarker [20]
MLH1 TTISG27 Limited Posttranslational Modification [21]
NCOA3 TT124R0 Limited Biomarker [22]
NOTCH1 TTB1STW Limited Biomarker [23]
PTPN11 TT7WUAV Limited Biomarker [24]
RGS2 TTKB7T3 Limited Altered Expression [25]
RGS4 TTGTKX9 Limited Altered Expression [25]
RICTOR TT143WL Limited Altered Expression [26]
ABCC3 TTVLG21 Disputed Biomarker [27]
AR TTKPW01 moderate Biomarker [22]
BMP1 TT0L58T moderate Altered Expression [28]
ESR1 TTZAYWL moderate Biomarker [22]
ESR2 TTOM3J0 moderate Biomarker [22]
FABP5 TTNT2S6 moderate Altered Expression [29]
G3BP1 TTG0R8Z moderate Biomarker [30]
HGF TT4V2JM moderate Biomarker [31]
NOTCH2 TT82FVD moderate Biomarker [23]
NTRK2 TTKN7QR moderate Biomarker [32]
S100A4 TTPR5SX moderate Altered Expression [33]
ADCY1 TTV1ZSQ Strong Biomarker [34]
ADH1A TT5AHZ0 Strong Biomarker [35]
ADK TTL732K Strong Biomarker [36]
AKR1C3 TT5ZWB6 Strong Biomarker [37]
ANXA1 TTUCK4B Strong Altered Expression [38]
AQP1 TTSF1KH Strong Altered Expression [39]
AQP9 TTQEI32 Strong Biomarker [40]
AURKB TT9RTBL Strong Altered Expression [41]
BIRC7 TTHZ8TA Strong Biomarker [42]
BST2 TT90BJT Strong Altered Expression [43]
CA12 TTSYM0R Strong Biomarker [44]
CA9 TT2LVK8 Strong Genetic Variation [45]
CALCR TTLWS2O Strong Altered Expression [46]
CD200 TT0BE68 Strong Altered Expression [47]
CD248 TTYJWT7 Strong Altered Expression [48]
CDC20 TTBKFDV Strong Altered Expression [49]
CDK2 TT7HF4W Strong Biomarker [50]
CDK4 TT0PG8F Strong Genetic Variation [51]
CHST15 TTFK7E1 Strong Biomarker [52]
CNP TT71P0H Strong Altered Expression [53]
CNTF TTGEM5Q Strong Altered Expression [54]
CNTN2 TT2Z1WB Strong Altered Expression [55]
CPE TTXPWO6 Strong Altered Expression [56]
CS TTZA6B3 Strong Biomarker [57]
CSF3R TTC70AJ Strong Altered Expression [58]
CTH TTLQUZS Strong Altered Expression [59]
CUL3 TTPCU0Q Strong Biomarker [60]
CYSLTR1 TTGKOY9 Strong Biomarker [61]
DLL3 TT1C9K6 Strong Biomarker [62]
DNPEP TTGMFY7 Strong Biomarker [63]
DUT TTH6MBO Strong Biomarker [64]
EGF TTED8JB Strong Altered Expression [65]
ENPEP TT9PBIL Strong Biomarker [63]
EPHA8 TTHZ2LW Strong Biomarker [66]
ERBB2 TTR5TV4 Strong Biomarker [67]
EYA2 TTUY9C6 Strong Altered Expression [68]
EZH1 TTNJA0C Strong Biomarker [69]
EZR TTE47YC Strong Biomarker [70]
F2RL2 TTVSEBF Strong Altered Expression [71]
FGFR4 TT1KX2S Strong Genetic Variation [72]
FPR2 TTOJ1NF Strong Altered Expression [38]
GAP43 TTSGLN5 Strong Altered Expression [73]
GAPDH TTUGSWA Strong Biomarker [74]
GAST TT4LRVO Strong Biomarker [75]
GFAP TTI6FFX Strong Altered Expression [76]
GLIPR1 TTEQF1O Strong Altered Expression [77]
GRIA2 TTWM461 Strong Biomarker [78]
GRM2 TTXJ47W Strong Biomarker [78]
GRM3 TT8A9EF Strong Altered Expression [79]
HDAC5 TTUELN5 Strong Posttranslational Modification [80]
HRH1 TTTIBOJ Strong Biomarker [81]
HTR1B TTK8CXU Strong Biomarker [82]
IGFBP2 TTU4QSN Strong Altered Expression [83]
IL13RA2 TTMPZ7V Strong Altered Expression [84]
ILK TT7ALZG Strong Altered Expression [85]
IMP3 TTEJA2R Strong Altered Expression [86]
KLK6 TTLPF4X Strong Altered Expression [87]
LAMP1 TTC214J Strong Altered Expression [88]
MBP TT2RY5P Strong Altered Expression [89]
MDM4 TT9OUDQ Strong Genetic Variation [90]
MELK TTBZOTY Strong Altered Expression [91]
MGMT TTJ8DV7 Strong Posttranslational Modification [92]
MKNK1 TTEZAUX Strong Altered Expression [93]
MMP15 TTNSTO3 Strong Altered Expression [94]
MMP16 TTNP4CU Strong Biomarker [94]
MYCBP TTVW4XU Strong Altered Expression [95]
NCR1 TTQNRJM Strong Altered Expression [96]
NES TTHZ752 Strong Biomarker [97]
NF2 TTZIK7P Strong Altered Expression [98]
OSM TTIVXSE Strong Altered Expression [99]
P2RX3 TT2THBD Strong Altered Expression [100]
P2RX4 TT1NLOA Strong Altered Expression [101]
P2RY1 TTA93TL Strong Altered Expression [102]
P2RY11 TTYXPCO Strong Genetic Variation [103]
P2RY12 TTZ1DT0 Strong Altered Expression [104]
P2RY6 TTNVSKA Strong Altered Expression [105]
PDE3B TTN34SQ Strong Altered Expression [53]
PDGFA TTSM78N Strong Altered Expression [106]
PDGFD TTSN0GA Strong Altered Expression [107]
PDGFRA TT8FYO9 Strong Biomarker [108]
PFKFB3 TTTHMQJ Strong Biomarker [109]
PGR TTUV8G9 Strong Altered Expression [110]
PLA2G2A TTO8QRU Strong Biomarker [111]
PLA2G4A TTT1JVS Strong Altered Expression [112]
PLCB1 TTLPGU7 Strong Altered Expression [113]
PLD1 TT3T17P Strong Biomarker [114]
PLD2 TTRLMKF Strong Altered Expression [114]
PPME1 TTXQ54R Strong Biomarker [115]
PSEN1 TTZ3S8C Strong Altered Expression [116]
PTGER3 TTPNGDE Strong Altered Expression [117]
PTN TTA9EJK Strong Biomarker [118]
PTPN13 TT405FP Strong Biomarker [119]
PTPN6 TT369M5 Strong Biomarker [60]
PTPRZ1 TT4SEA8 Strong Altered Expression [120]
RAC3 TT9BQ50 Strong Genetic Variation [121]
RAPGEF4 TTOS63B Strong Biomarker [34]
RGS6 TTJ96M8 Strong Biomarker [122]
RIPK2 TTCQ2E5 Strong Biomarker [123]
RNPEP TTD74YX Strong Biomarker [63]
RTN4R TTVRZUO Strong Biomarker [124]
SAA1 TTY0DN9 Strong Altered Expression [125]
SENP1 TTW9HY5 Strong Biomarker [126]
SERPINA6 TTJL8VG Strong Altered Expression [127]
SGPL1 TT618Q2 Strong Biomarker [128]
SIRPA TTBRJS9 Strong Altered Expression [129]
SLC1A2 TT2F078 Strong Altered Expression [130]
SLC6A12 TTQBMPI Strong Altered Expression [131]
SLC6A8 TTYUHB5 Strong Altered Expression [46]
SLC7A5 TTPH2JB Strong Biomarker [132]
SPHK2 TTCN0M9 Strong Biomarker [133]
SRC TT6PKBN Strong Biomarker [134]
ST8SIA4 TTDP8YM Strong Altered Expression [135]
TACR1 TTZPO1L Strong Altered Expression [136]
TBXA2R TT2O84V Strong Biomarker [137]
TLR6 TTWRI8V Strong Biomarker [138]
TNFRSF21 TT8UA0T Strong Biomarker [139]
TNKS TTVUSO7 Strong Biomarker [140]
TOP2B TT4NVEM Strong Biomarker [141]
TRH TT2Z39D Strong Altered Expression [142]
TXN TTZJ5U9 Strong Biomarker [143]
VEGFB TTPJQHE Strong Biomarker [144]
ZAP70 TTUMHT8 Strong Biomarker [145]
CACNA1F TTJ0SO4 Definitive Biomarker [146]
FTH1 TT975ZT Definitive Biomarker [147]
HIPK2 TTOB49C Definitive Altered Expression [148]
MSH2 TTCAWRT Definitive Altered Expression [21]
NCK1 TTMA3VF Definitive Biomarker [149]
NPM1 TTHBS98 Definitive Biomarker [150]
------------------------------------------------------------------------------------
⏷ Show the Full List of 159 DTT(s)
This Disease Is Related to 2 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC5A8 DTE3TAW Limited Posttranslational Modification [151]
SLC25A3 DTCRIWV Strong Genetic Variation [152]
------------------------------------------------------------------------------------
This Disease Is Related to 11 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ADH1C DEM1HNL Strong Biomarker [35]
ADH4 DEOCWU3 Strong Biomarker [35]
ADH6 DE017IC Strong Biomarker [35]
AKR7A2 DE4G629 Strong Biomarker [37]
CYP4F3 DEFCMPI Strong Genetic Variation [153]
EGLN3 DEMQTKH Strong Genetic Variation [154]
GSTM1 DEYZEJA Strong Genetic Variation [155]
MT1A DE5ME8A Strong Posttranslational Modification [156]
NT5C DE4E31Z Strong Biomarker [157]
NT5C2 DE1DOKJ Strong Altered Expression [158]
SULT2A1 DE0P6LK Strong Biomarker [145]
------------------------------------------------------------------------------------
⏷ Show the Full List of 11 DME(s)
This Disease Is Related to 269 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
A2M OTFTX90K Limited Altered Expression [159]
ADARB1 OTGKSZEV Limited Altered Expression [160]
ADARB2 OTDJKS39 Limited Biomarker [161]
ATF5 OT03QCLM Limited Altered Expression [162]
CDKN2B OTAG24N1 Limited Genetic Variation [163]
CHI3L1 OT2Z7VJH Limited Altered Expression [164]
DIRAS1 OT07F6PE Limited Biomarker [165]
DMBT1 OTVNU9D9 Limited Genetic Variation [166]
DOK2 OTIJ38UF Limited Biomarker [167]
ELFN2 OT9C5F0K Limited Biomarker [168]
EXO1 OTI87RS5 Limited Altered Expression [169]
GOLGA4 OTCMEHNJ Limited Altered Expression [170]
MPST OTCDPH5D Limited Biomarker [171]
MSH3 OTD3YPVL Limited Biomarker [27]
NEIL3 OTBCI2NS Limited Altered Expression [169]
NF1 OTC29NHH Limited Biomarker [172]
PCDHGA11 OTK9136T Limited Biomarker [173]
PFKFB4 OTQYEXL2 Limited Biomarker [109]
RGS3 OTYG5OXI Limited Altered Expression [25]
RPS15 OT0WYZYG Limited Biomarker [165]
RPS6 OTT4D1LN Limited Biomarker [174]
SH3BP4 OTVIRKW7 Limited Genetic Variation [175]
SHC3 OT305NPA Limited Biomarker [176]
TAC4 OTYWPPM3 Limited Biomarker [13]
TANK OTZSGFIK Limited Altered Expression [177]
TBX2 OTTOT7A9 Limited Altered Expression [178]
TNFRSF6B OTKAN9G7 Limited Biomarker [179]
TSC2 OT47LWI9 Limited Genetic Variation [180]
APOD OTT77XW8 Disputed Altered Expression [181]
ATP1B2 OTYTBYVU Disputed Altered Expression [181]
ATRN OTTCLOPV Disputed Altered Expression [182]
BDH2 OTDD7G8S Disputed Altered Expression [181]
DMXL1 OTWVL31L Disputed Altered Expression [181]
MARCKSL1 OT13J2FM Disputed Biomarker [27]
PSD3 OTTN9B9O Disputed Altered Expression [181]
ALDH1L1 OT15HOJX moderate Altered Expression [183]
CCDC88A OT3SSYYC moderate Biomarker [167]
CCNT1 OTDYVGCP moderate Altered Expression [184]
ECT2 OTQDUCT6 moderate Biomarker [30]
KIF14 OTXHT4JM moderate Biomarker [185]
LATS1 OTOOCG4R moderate Biomarker [186]
MATN2 OTVDR68G moderate Biomarker [187]
NDRG1 OTVO66BO moderate Biomarker [188]
RBP2 OTR8QG5V moderate Altered Expression [29]
ACSL5 OT3L9XO3 Strong Biomarker [128]
ACTN1 OTUCLNXH Strong Biomarker [189]
ADAM12 OTZKOTDB Strong Biomarker [190]
ADGRG1 OTQBB8NT Strong Altered Expression [191]
AKAP12 OTCVRDDX Strong Biomarker [192]
AMPD1 OTU17BCI Strong Biomarker [193]
ANKRD1 OTHJ7JV9 Strong Biomarker [194]
AP5M1 OTDLWEBL Strong Biomarker [195]
AP5Z1 OTXIPLFH Strong Biomarker [196]
AQP4 OTA9MYD5 Strong Altered Expression [197]
AQP8 OT99JKME Strong Biomarker [198]
ARHGEF28 OT3F32IU Strong Biomarker [123]
ARHGEF7 OT9BPJCL Strong Altered Expression [199]
ASCC1 OTH4VAP9 Strong Altered Expression [199]
ASCL1 OTI4X44G Strong Biomarker [200]
ATAD3B OTL508AF Strong Biomarker [201]
ATP23 OT303R2T Strong Biomarker [202]
ATRX OT77RSQW Strong Genetic Variation [203]
BCCIP OTFFKG79 Strong Biomarker [204]
BLCAP OTGJVU0C Strong Altered Expression [205]
BRINP1 OTEUVSCP Strong Altered Expression [206]
BTRC OT2EZDGR Strong Biomarker [207]
C2 OTHMF4YM Strong Altered Expression [208]
CA8 OT9Y8GA8 Strong Biomarker [194]
CAMTA1 OTAN1S5B Strong Genetic Variation [209]
CCL14 OT8QETQU Strong Biomarker [210]
CCNG2 OTII38K2 Strong Altered Expression [211]
CD63 OT2UGZA9 Strong Biomarker [212]
CD93 OT6HZT6H Strong Altered Expression [213]
CD99 OTPUZ5DE Strong Altered Expression [214]
CDC14B OTAESVOZ Strong Altered Expression [215]
CDCA5 OTZLCQ5U Strong Altered Expression [216]
CETN2 OTJTTGS0 Strong Altered Expression [217]
CETN3 OTG4PL7H Strong Altered Expression [217]
CIC OTFXCHNZ Strong Genetic Variation [218]
CIITA OTRJNZFO Strong Altered Expression [219]
CITED4 OTR6NHI2 Strong Genetic Variation [220]
COL6A1 OTYKSCOB Strong Altered Expression [221]
CPEB1 OTLCXC6H Strong Biomarker [222]
CT55 OTQC0H27 Strong Biomarker [204]
CTNNA1 OTFC725Z Strong Altered Expression [223]
CTNNA3 OT9Z0P1E Strong Altered Expression [223]
CXCL6 OTFTCQ4O Strong Altered Expression [170]
DCX OTISR7K3 Strong Altered Expression [224]
DIAPH2 OTBEYFEZ Strong Genetic Variation [225]
DSC3 OTYG47F8 Strong Biomarker [226]
DSTN OTMXO4YB Strong Biomarker [143]
DVL3 OTPRROHJ Strong Biomarker [227]
E2F4 OTB3JFH4 Strong Biomarker [228]
EIF3A OTFABY9G Strong Altered Expression [229]
EMC10 OTQ6S50X Strong Biomarker [230]
EMP3 OTODMJ1D Strong Biomarker [231]
EXT1 OTRPALJK Strong Biomarker [232]
FABP7 OTRE2H4G Strong Altered Expression [233]
FASTK OTTHFZMP Strong Altered Expression [234]
FCN2 OTTHJBKZ Strong Altered Expression [216]
FKTN OTQ9GCXL Strong Altered Expression [235]
FLII OT7G9JG6 Strong Biomarker [236]
FOCAD OT83QOSI Strong Biomarker [237]
FUBP1 OT77SC9N Strong Genetic Variation [238]
GCHFR OTEOT8GI Strong Altered Expression [216]
GLG1 OT7X0W3N Strong Biomarker [239]
GLS2 OT08MSHL Strong Altered Expression [162]
GNL3 OTILGYO4 Strong Altered Expression [240]
GOLPH3 OTDLGYM3 Strong Altered Expression [241]
GPR158 OTYOC1RQ Strong Altered Expression [242]
GPR162 OTK4LT3K Strong Biomarker [243]
H3-3B OT9XHQ3C Strong Altered Expression [244]
HAS2 OTTD3PAL Strong Biomarker [245]
HELLS OTVVV668 Strong Altered Expression [246]
HES5 OTW7JEHV Strong Altered Expression [247]
HES6 OTWO5SCF Strong Altered Expression [248]
HEY1 OTJQL0I3 Strong Biomarker [62]
HEY2 OTU4J3ZI Strong Biomarker [62]
HFE OTDD93KB Strong Biomarker [249]
HJV OT4235J2 Strong Biomarker [250]
HOXD9 OTZ4GVR1 Strong Altered Expression [251]
HRK OTR4GWJ0 Strong Posttranslational Modification [252]
ID4 OTPMJ39I Strong Altered Expression [253]
IFI35 OTV9RZ53 Strong Altered Expression [254]
IFIT1 OTXOQDSG Strong Altered Expression [255]
IFIT2 OTI4EOAR Strong Altered Expression [255]
IGFALS OTTWCZYM Strong Biomarker [160]
IGFBP4 OT2HZRBD Strong Altered Expression [256]
ING4 OT0VVG4V Strong Biomarker [257]
IRF7 OTC1A2PQ Strong Biomarker [258]
ITIH4 OT460OO1 Strong Biomarker [259]
IVNS1ABP OTYHL4I7 Strong Biomarker [24]
KAZALD1 OTSFOX2H Strong Biomarker [260]
KCNE1 OTZNQUW9 Strong Altered Expression [261]
KIAA1549 OTA5B18F Strong Genetic Variation [262]
KLF6 OTQY9S7F Strong Genetic Variation [263]
KPNA2 OTU7FOE6 Strong Biomarker [264]
LGALS4 OTKQCG0H Strong Altered Expression [265]
LGI1 OTPS77HO Strong Altered Expression [266]
LRRN2 OTGP2DCY Strong Biomarker [267]
LSM4 OTLKJB3A Strong Genetic Variation [268]
LSP1 OTSPSIFO Strong Biomarker [269]
LZTR1 OTIDM6XO Strong Biomarker [270]
MACC1 OTV3DLX0 Strong Altered Expression [271]
MAP1LC3B OTUYHB84 Strong Biomarker [272]
MAP9 OTZD5099 Strong Biomarker [63]
MATK OTVOJJLJ Strong Altered Expression [273]
MINDY3 OT6YZPWC Strong Biomarker [194]
MLC1 OTCNZLSP Strong Biomarker [274]
MMP19 OTLSTT2B Strong Altered Expression [275]
MMP26 OT9O89KU Strong Altered Expression [276]
MNAT1 OTXLOYCB Strong Altered Expression [216]
MRPL28 OT4LUTZU Strong Genetic Variation [277]
MVP OTJGHJRB Strong Altered Expression [278]
MXD1 OTS5CTHX Strong Biomarker [193]
MYBL1 OTBJMC2P Strong Biomarker [279]
NANOS3 OTGX9IQU Strong Altered Expression [280]
NAP1L1 OTI7WBZV Strong Altered Expression [281]
NAPSA OT6F8IAL Strong Altered Expression [282]
NCOA1 OTLIUJQD Strong Biomarker [134]
NCOA6 OTOMIGTV Strong Altered Expression [283]
NDRG2 OT5L6KD7 Strong Biomarker [284]
NEURL1 OT2C4P70 Strong Altered Expression [285]
NFATC3 OTYOORME Strong Altered Expression [286]
NFIA OTDHQ9CG Strong Altered Expression [287]
NFIB OTX94PD0 Strong Altered Expression [287]
NKX2-2 OTDCOYNG Strong Biomarker [200]
NLRC4 OTAIA3NA Strong Altered Expression [288]
NOVA1 OT6A9KHY Strong Biomarker [289]
NPAS3 OT8D1ILB Strong Biomarker [290]
NR1D2 OT9CVF41 Strong Biomarker [291]
NR2F2 OTJFS67N Strong Altered Expression [292]
NUFIP2 OTZBZ224 Strong Biomarker [293]
NUP98 OTNT12G2 Strong Altered Expression [160]
NUSAP1 OT85HIJ5 Strong Altered Expression [294]
NXT1 OT0VO6AY Strong Genetic Variation [277]
OLIG2 OTMCN6D3 Strong Biomarker [295]
OPTN OT2UXWH9 Strong Altered Expression [281]
PDIK1L OTISF4KG Strong Biomarker [296]
PEA15 OTKCKTSX Strong Biomarker [297]
PGAM1 OTZ5DB06 Strong Altered Expression [298]
PHF20 OTCBVH5P Strong Biomarker [299]
PHF3 OTNOYLG9 Strong Altered Expression [300]
PHLPP1 OTIFXW8D Strong Altered Expression [207]
PID1 OT5YJ7FI Strong Altered Expression [301]
PIEZO1 OTBG1FU4 Strong Genetic Variation [302]
PLA2G10 OTRZ2L5A Strong Biomarker [111]
PLEC OTU4XDEG Strong Altered Expression [303]
PLK5 OTW5YPKM Strong Posttranslational Modification [304]
PLP1 OT8CM9CX Strong Altered Expression [305]
PODXL OTPNQXF3 Strong Biomarker [306]
PPAN OT0UFQBZ Strong Genetic Variation [103]
PPP1R13L OTNCPLWE Strong Altered Expression [307]
PPP1R1A OTGTAGCV Strong Biomarker [308]
PRDM16 OT0BGA27 Strong Altered Expression [309]
PRND OTH4EEMI Strong Biomarker [310]
PROX1 OT68R6IO Strong Altered Expression [311]
PRPS1 OTN3A6CN Strong Biomarker [312]
PSMA5 OT38E6Y1 Strong Biomarker [196]
PTPRA OTZA82J1 Strong Altered Expression [278]
PTPRT OTV5TXNN Strong Altered Expression [313]
PTPRU OTHDO0QG Strong Genetic Variation [152]
QKI OTTAUGLB Strong Genetic Variation [32]
RAB23 OTBAKFBR Strong Biomarker [314]
RAB27B OTPF9D0K Strong Biomarker [315]
RAC2 OTAOHFNH Strong Altered Expression [316]
RASD1 OT2BAJHK Strong Altered Expression [317]
RASGRF1 OTNWJ7EN Strong Altered Expression [318]
RASL10A OTEXTN6I Strong Altered Expression [319]
RASSF10 OTGB7EBG Strong Posttranslational Modification [320]
RB1CC1 OTZK8PFX Strong Biomarker [210]
RBM10 OTES2MES Strong Altered Expression [321]
RBM3 OTAJ7R31 Strong Biomarker [321]
RBMX OTFZN66E Strong Altered Expression [321]
RGCC OTYJMLWM Strong Biomarker [322]
RNF138 OTPU0CO4 Strong Altered Expression [323]
RO60 OTLGM5A8 Strong Biomarker [324]
RPLP0 OT3XKD6Y Strong Altered Expression [325]
RYR2 OT0PF19E Strong Genetic Variation [326]
S100A13 OT582SUS Strong Altered Expression [327]
SAA2 OTYAVJWG Strong Altered Expression [125]
SCARB2 OTN929M8 Strong Biomarker [310]
SCG5 OTXSJMT1 Strong Posttranslational Modification [328]
SDC4 OTKUVUGZ Strong Biomarker [232]
SDHA OTOJ8QFF Strong Biomarker [329]
SEMA5A OTUOIOJV Strong Altered Expression [330]
SEPTIN2 OT3G33TM Strong Altered Expression [331]
SEPTIN4 OTD16B30 Strong Biomarker [312]
SERPINE2 OTYF5340 Strong Altered Expression [332]
SIAH1 OT29A838 Strong Biomarker [74]
SIX3 OTP5E3VU Strong Altered Expression [41]
SMARCA2 OTSGJ8SV Strong Biomarker [333]
SNRPN OTQB1ID1 Strong Altered Expression [334]
SOHLH1 OT3RBLSK Strong Altered Expression [335]
SOX10 OTF25ULQ Strong Biomarker [336]
SOX11 OT4LG7LA Strong Altered Expression [337]
SPAST OTIF3AJI Strong Altered Expression [338]
ST8SIA2 OTRBBBD8 Strong Altered Expression [135]
STARD13 OTB4U1HY Strong Biomarker [339]
STX1A OTSBUZB4 Strong Altered Expression [340]
SUB1 OTK71JYU Strong Genetic Variation [277]
TAC1 OTM842YW Strong Biomarker [341]
TARBP2 OT1QQ8H3 Strong Altered Expression [283]
TAT OT2CJ91O Strong Altered Expression [342]
TCF7 OT1ID822 Strong Altered Expression [227]
TFB1M OTFCUSAZ Strong Biomarker [343]
TFB2M OTG9DUU1 Strong Biomarker [343]
TFR2 OTMYCCEO Strong Biomarker [250]
TGFB1I1 OTIK337D Strong Altered Expression [344]
TGFBI OTR443C5 Strong Biomarker [345]
TIMP1 OTOXC51H Strong Biomarker [212]
TIMP4 OT8A68SW Strong Altered Expression [346]
TLE2 OT2KSZ9B Strong Altered Expression [347]
TM7SF2 OTILU5S7 Strong Biomarker [348]
TMPRSS13 OTMAOAP3 Strong Biomarker [349]
TOP3A OT3CKUI9 Strong Altered Expression [350]
TRAF3 OT5TQBGV Strong Biomarker [123]
TSC1 OTFF4YZ7 Strong Biomarker [351]
TSC22D1 OTN4GFWD Strong Altered Expression [352]
CRABP2 OTY01V9G Definitive Altered Expression [29]
EFNB1 OT7JJW8P Definitive Altered Expression [353]
EFNB2 OT0DCUOM Definitive Biomarker [353]
HLA-DRB4 OTNXIHQU Definitive Posttranslational Modification [354]
LHX9 OTDPEHC4 Definitive Posttranslational Modification [355]
MCPH1 OTYT3TT5 Definitive Altered Expression [356]
MSH6 OT46FP09 Definitive Biomarker [21]
NEFL OTQESJV4 Definitive Altered Expression [357]
RASSF5 OT6Q41I2 Definitive Biomarker [358]
SPAG9 OT45AHMB Definitive Biomarker [306]
------------------------------------------------------------------------------------
⏷ Show the Full List of 269 DOT(s)

References

1 Physical approaches to treat glioblastoma. Curr Opin Oncol. 2020 Nov;32(6):640-649.
2 Dacarbazine FDA Label
3 Irinotecan FDA Label
4 Temozolomide FDA Label
5 ClinicalTrials.gov (NCT03027388) Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma. U.S. National Institutes of Health.
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 ClinicalTrials.gov (NCT04047303) CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma. U.S. National Institutes of Health.
8 Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma.Nat Genet. 2014 May;46(5):462-6. doi: 10.1038/ng.2950. Epub 2014 Apr 6.
9 Regulation of the pathological vasculature of malignant astrocytomas by angiopoietin-1.Neoplasia. 2005 Dec;7(12):1081-90. doi: 10.1593/neo.05424.
10 Expression Profile of Genes Related to Drug Metabolism in Human Brain Tumors.PLoS One. 2015 Nov 18;10(11):e0143285. doi: 10.1371/journal.pone.0143285. eCollection 2015.
11 High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients.Oncol Rep. 2017 May;37(5):2865-2874. doi: 10.3892/or.2017.5528. Epub 2017 Mar 24.
12 Clinicopathological characteristics of circumscribed high-grade astrocytomas with an unusual combination of BRAF V600E, ATRX, and CDKN2A/B alternations.Brain Tumor Pathol. 2019 Jul;36(3):103-111. doi: 10.1007/s10014-019-00344-z. Epub 2019 Apr 10.
13 Hemokinin-1 has Substance P-like function in U-251 MG astrocytoma cells: a pharmacological and functional study.J Neuroimmunol. 2005 Jul;164(1-2):48-56. doi: 10.1016/j.jneuroim.2005.03.016.
14 FGFR1 Expression and Role in Migration in Low and High Grade Pediatric Gliomas.Front Oncol. 2019 Mar 13;9:103. doi: 10.3389/fonc.2019.00103. eCollection 2019.
15 Complementation of dopaminergic signaling by Pitx3-GDNF synergy induces dopamine secretion by multipotent Ntera2 cells.J Cell Biochem. 2020 Jan;121(1):200-212. doi: 10.1002/jcb.29109. Epub 2019 Jul 16.
16 Disappearance of gadolinium enhancement in a chemoresistant astrocytoma of the tectum after high-dose interferon beta.Tumori. 2008 Nov-Dec;94(6):853-5. doi: 10.1177/030089160809400614.
17 Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas.Neurosci Lett. 2003 Jul 31;346(1-2):33-6. doi: 10.1016/s0304-3940(03)00562-7.
18 Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.Nat Genet. 2013 Aug;45(8):927-32. doi: 10.1038/ng.2682. Epub 2013 Jun 30.
19 Promoter Hypermethylation of Genes Encoding for RASSF/Hippo Pathway Members Reveals Specific Alteration Pattern in Diffuse Gliomas.J Mol Diagn. 2019 Jul;21(4):695-704. doi: 10.1016/j.jmoldx.2019.03.007. Epub 2019 May 2.
20 Usefulness of [(11)C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma.Neurol Med Chir (Tokyo). 2019 May 15;59(5):176-183. doi: 10.2176/nmc.oa.2018-0287. Epub 2019 Apr 17.
21 Integrated analysis of mismatch repair system in malignant astrocytomas.PLoS One. 2013 Sep 20;8(9):e76401. doi: 10.1371/journal.pone.0076401. eCollection 2013.
22 Expression of estrogen receptors, androgen receptor and steroid receptor coactivator-3 is negatively correlated to the differentiation of astrocytic tumors.Cancer Epidemiol. 2014 Jun;38(3):291-7. doi: 10.1016/j.canep.2014.03.001. Epub 2014 Mar 27.
23 The different role of Notch1 and Notch2 in astrocytic gliomas.PLoS One. 2013;8(1):e53654. doi: 10.1371/journal.pone.0053654. Epub 2013 Jan 21.
24 Remodeling of the Actin Network Associated with the Non-Structural Protein 1 (NS1) of West Nile Virus and Formation of NS1-Containing Tunneling Nanotubes.Viruses. 2019 Sep 27;11(10):901. doi: 10.3390/v11100901.
25 Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells.PLoS One. 2015 Aug 11;10(8):e0134934. doi: 10.1371/journal.pone.0134934. eCollection 2015.
26 Evaluation of Akt and RICTOR Expression Levels in Astrocytomas of All Grades.J Histochem Cytochem. 2017 Feb;65(2):93-103. doi: 10.1369/0022155416675850. Epub 2016 Oct 28.
27 Comparison between cells and cancer stem-like cells isolated from glioblastoma and astrocytoma on expression of anti-apoptotic and multidrug resistance-associated protein genes.Neuroscience. 2008 Jun 23;154(2):541-50. doi: 10.1016/j.neuroscience.2008.03.054. Epub 2008 Apr 1.
28 LOX expression and functional analysis in astrocytomas and impact of IDH1 mutation.PLoS One. 2015 Mar 19;10(3):e0119781. doi: 10.1371/journal.pone.0119781. eCollection 2015.
29 CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid.Oncotarget. 2015 Mar 20;6(8):5889-902. doi: 10.18632/oncotarget.3334.
30 Epithelial Cell Transforming 2 and Aurora Kinase B Modulate Formation of Stress Granule-Containing Transcripts from Diverse Cellular Pathways in Astrocytoma?Cells. Am J Pathol. 2016 Jun;186(6):1674-87. doi: 10.1016/j.ajpath.2016.02.013. Epub 2016 Apr 20.
31 Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells.Brain Res Mol Brain Res. 2004 Feb 5;121(1-2):146-50. doi: 10.1016/j.molbrainres.2003.11.008.
32 Tyrosine receptor kinase B is a drug target in astrocytomas.Neuro Oncol. 2017 Jan;19(1):22-30. doi: 10.1093/neuonc/now139. Epub 2016 Jul 10.
33 S100A4 expression is closely linked to genesis and progression of glioma by regulating proliferation, apoptosis, migration and invasion.Asian Pac J Cancer Prev. 2015;16(7):2883-7. doi: 10.7314/apjcp.2015.16.7.2883.
34 Selective 2 adrenergic agonist increases Cx43 and miR-451 expression via cAMP-Epac.Mol Med Rep. 2014 Jun;9(6):2405-10. doi: 10.3892/mmr.2014.2120. Epub 2014 Apr 8.
35 The role of aldehyde reductase AKR1A1 in the metabolism of -hydroxybutyrate in 1321N1 human astrocytoma cells.Chem Biol Interact. 2011 May 30;191(1-3):303-7. doi: 10.1016/j.cbi.2011.01.018. Epub 2011 Jan 26.
36 Stable Knockdown of Adenosine Kinase by Lentiviral Anti-ADK miR-shRNAs in Wharton's Jelly Stem Cells.Cell J. 2018 Apr;20(1):1-9. doi: 10.22074/cellj.2018.4916. Epub 2017 Dec 1.
37 Inducible protection of human astrocytoma 1321N1 cells against hydrogen peroxide and aldehyde toxicity by 7-hydroxycoumarin is associated with the upregulation of aldo-keto reductases. Neurotoxicology. 2012 Oct;33(5):1368-74.
38 Expression of the Annexin A1 and its correlation with matrix metalloproteinases and the receptor for formylated peptide-2 in diffuse astrocytic tumors.Ann Diagn Pathol. 2018 Dec;37:62-66. doi: 10.1016/j.anndiagpath.2018.08.002. Epub 2018 Sep 3.
39 Aquaporin Positron Emission Tomography Differentiates Between Grade III and IV Human Astrocytoma.Neurosurgery. 2018 Jun 1;82(6):842-846. doi: 10.1093/neuros/nyx314.
40 AQP9 promotes astrocytoma cell invasion and motility via the AKT pathway.Oncol Lett. 2018 Nov;16(5):6059-6064. doi: 10.3892/ol.2018.9361. Epub 2018 Aug 23.
41 SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B.J Hematol Oncol. 2017 Jun 8;10(1):115. doi: 10.1186/s13045-017-0483-2.
42 Apoptosis and proliferation markers in diffusely infiltrating astrocytomas: profiling of 17 molecules.J Neuropathol Exp Neurol. 2006 Sep;65(9):905-13. doi: 10.1097/01.jnen.0000235857.79502.c3.
43 The expression of BST2 in human and experimental mouse brain tumors.Exp Mol Pathol. 2011 Aug;91(1):440-6. doi: 10.1016/j.yexmp.2011.04.012. Epub 2011 May 1.
44 Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas.Neuro Oncol. 2008 Apr;10(2):131-8. doi: 10.1215/15228517-2007-065. Epub 2008 Mar 5.
45 Hsp27 and its expression pattern in diffusely infiltrating astrocytomas.Histol Histopathol. 2014 Sep;29(9):1161-8. doi: 10.14670/HH-29.1161. Epub 2014 Mar 6.
46 Kinase inhibitors abrogate IFN-gamma-induced class II transactivator and class II MHC gene expression in astroglioma cell lines.J Neuroimmunol. 1998 May 15;85(2):174-85. doi: 10.1016/s0165-5728(98)00010-1.
47 Reduction of CD200 expression in glioma cells enhances microglia activation and tumor growth.J Neurosci Res. 2016 Dec;94(12):1460-1471. doi: 10.1002/jnr.23922. Epub 2016 Sep 15.
48 Characterization of TEM1/endosialin in human and murine brain tumors.BMC Cancer. 2009 Nov 30;9:417. doi: 10.1186/1471-2407-9-417.
49 CDC20 with malignant progression and poor prognosis of astrocytoma revealed by analysis on gene expression.J Neurooncol. 2017 May;133(1):87-95. doi: 10.1007/s11060-017-2434-8. Epub 2017 Apr 21.
50 CDKN2/p16 predicts survival in oligodendrogliomas: comparison with astrocytomas.J Neurooncol. 1999 Feb;41(3):205-11. doi: 10.1023/a:1006185220369.
51 Total copy number variation as a prognostic factor in adult astrocytoma subtypes.Acta Neuropathol Commun. 2019 Jun 10;7(1):92. doi: 10.1186/s40478-019-0746-y.
52 Role of GalNAc4S-6ST in astrocytic tumor progression.PLoS One. 2013;8(1):e54278. doi: 10.1371/journal.pone.0054278. Epub 2013 Jan 17.
53 Molecular markers that identify human astrocytomas and oligodendrogliomas.J Neuropathol Exp Neurol. 2002 Apr;61(4):329-38. doi: 10.1093/jnen/61.4.329.
54 Ciliary neurotrophic factor is a key sex-specific regulator of depressive-like behavior in mice.Psychoneuroendocrinology. 2019 Feb;100:96-105. doi: 10.1016/j.psyneuen.2018.09.038. Epub 2018 Sep 29.
55 Proinflammatory cytokine gene induction by human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 Tax in primary human glial cells.J Virol. 2007 Feb;81(4):1690-700. doi: 10.1128/JVI.01513-06. Epub 2006 Nov 22.
56 Carboxypeptidase E: elevated expression correlated with tumor growth and metastasis in pheochromocytomas and other cancers.Cell Mol Neurobiol. 2010 Nov;30(8):1377-81. doi: 10.1007/s10571-010-9592-y.
57 Treatment of human astrocytoma U87 cells with silicon dioxide nanoparticles lowers their survival and alters their expression of mitochondrial and cell signaling proteins.Int J Nanomedicine. 2010 Oct 5;5:715-23. doi: 10.2147/IJN.S5238.
58 Granulocyte colony-stimulating factor (G-CSF) production by astrocytoma cells and its effect on tumor growth.J Neurooncol. 1996 Jan;27(1):31-8. doi: 10.1007/BF00146081.
59 Cystathionine Promotes the Proliferation of Human Astrocytoma U373 Cells.Anticancer Res. 2018 Jun;38(6):3501-3505. doi: 10.21873/anticanres.12621.
60 Gene expression meta-analysis in diffuse low-grade glioma and the corresponding histological subtypes.Sci Rep. 2017 Sep 18;7(1):11741. doi: 10.1038/s41598-017-12087-y.
61 Expression of cysteinyl leukotriene receptor 1 in human traumatic brain injury and brain tumors.Neurosci Lett. 2004 Jun 17;363(3):247-51. doi: 10.1016/j.neulet.2004.03.088.
62 Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.Genes Cancer. 2010 Aug;1(8):822-35. doi: 10.1177/1947601910383564.
63 Differential Effects of Doxazosin on Renin-Angiotensin-System- Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells.CNS Neurol Disord Drug Targets. 2019;18(1):29-36. doi: 10.2174/1871527317666181029111739.
64 Immunohistochemical detection of dUTPase in intracranial tumors.Pathol Res Pract. 2005;201(11):727-32. doi: 10.1016/j.prp.2005.08.005. Epub 2005 Oct 19.
65 Epidermal growth factor receptor-mediated regulation of urokinase plasminogen activator expression and glioblastoma invasion via C-SRC/MAPK/AP-1 signaling pathways.J Neuropathol Exp Neurol. 2010 Jun;69(6):582-92. doi: 10.1097/NEN.0b013e3181e008fe.
66 Increased expression in human astrocytomas of a 100 kDa protein with sequence homology to the ros tyrosine kinase domain.Neurol Res. 1993 Oct;15(5):316-20. doi: 10.1080/01616412.1993.11740154.
67 c-erbB-2 protein expression in astrocytic tumors of the brain.Med Sci Monit. 2011 Aug;17(8):BR216-220. doi: 10.12659/msm.881900.
68 Eya2 overexpression promotes the invasion of human astrocytoma through the regulation of ERK/MMP9 signaling.Int J Mol Med. 2017 Nov;40(5):1315-1322. doi: 10.3892/ijmm.2017.3132. Epub 2017 Sep 13.
69 Altered expression of polycomb group genes in glioblastoma multiforme.PLoS One. 2013 Nov 15;8(11):e80970. doi: 10.1371/journal.pone.0080970. eCollection 2013.
70 Perspectives for Ezrin and Radixin in Astrocytes: Kinases, Functions and Pathology.Int J Mol Sci. 2019 Aug 2;20(15):3776. doi: 10.3390/ijms20153776.
71 The protease-activated receptor-3 (PAR-3) can signal autonomously to induce interleukin-8 release.Cell Mol Life Sci. 2008 Mar;65(6):970-81. doi: 10.1007/s00018-008-7555-y.
72 Assessment of tumor cell invasion factors in gliomatosis cerebri.J Neurooncol. 2005 Jun;73(2):109-15. doi: 10.1007/s11060-004-4206-5.
73 Aberrant GAP-43 gene expression in Alzheimer's disease.Am J Pathol. 1995 Oct;147(4):934-46.
74 E3 ubiquitin ligase siah? nuclear accumulation is critical for homocysteineinduced impairment of C6 astroglioma cells.Mol Med Rep. 2019 Sep;20(3):2227-2235. doi: 10.3892/mmr.2019.10449. Epub 2019 Jul 1.
75 C-terminal heptapeptide of gastrin inhibits astrocytomas motility by interacting with a new gastrin binding site.J Pharmacol Exp Ther. 2002 Jul;302(1):274-82. doi: 10.1124/jpet.302.1.274.
76 Clinicopathological characteristics of dysplastic teratomous neuroglia with anti-N-methyl-d-aspartate receptor encephalitis.Clin Immunol. 2020 Jan;210:108271. doi: 10.1016/j.clim.2019.108271. Epub 2019 Nov 19.
77 Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells.Biochem Biophys Res Commun. 2007 Oct 26;362(3):612-8. doi: 10.1016/j.bbrc.2007.08.138. Epub 2007 Aug 31.
78 Potential bioisosteres of -uracilalanines derived from 1H-1,2,3-triazole-C-carboxylic acids.Bioorg Chem. 2019 Mar;83:500-510. doi: 10.1016/j.bioorg.2018.10.061. Epub 2018 Nov 7.
79 Identification and characterization of the promoter region of the GRM3 gene.Biochem Biophys Res Commun. 2001 Aug 17;286(2):381-7. doi: 10.1006/bbrc.2001.5391.
80 Abnormal methylation of histone deacetylase genes: implications on etiology and epigenetic therapy of astrocytomas.Anticancer Res. 2011 Apr;31(4):1337-43.
81 Histamine-induced Ca2+ entry in human astrocytoma U373 MG cells: evidence for involvement of store-operated channels.J Neurosci Res. 2008 Nov 15;86(15):3456-68. doi: 10.1002/jnr.21784.
82 Serotonin and Dopamine Receptor Expression in Solid Tumours Including Rare Cancers.Pathol Oncol Res. 2020 Jul;26(3):1539-1547. doi: 10.1007/s12253-019-00734-w. Epub 2019 Sep 2.
83 Grade-specific expression of insulin-like growth factor-binding proteins-2, -3, and -5 in astrocytomas: IGFBP-3 emerges as a strong predictor of survival in patients with newly diagnosed glioblastoma.Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1399-408. doi: 10.1158/1055-9965.EPI-09-1213. Epub 2010 May 25.
84 Interleukin-13 receptor alpha 2 as a marker of poorer prognosis in high-grade astrocytomas.J Neurosurg Sci. 2018 Jun;62(3):239-244. doi: 10.23736/S0390-5616.16.03793-0. Epub 2017 Jan 12.
85 MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma.J Biol Chem. 2015 Oct 9;290(41):24678-88. doi: 10.1074/jbc.M115.649004. Epub 2015 Aug 18.
86 Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways by modulating IGF-2.J Biol Chem. 2011 Jul 22;286(29):25882-90. doi: 10.1074/jbc.M110.178012. Epub 2011 May 25.
87 Clinical significance and novel mechanism of action of kallikrein 6 in glioblastoma.Neuro Oncol. 2013 Mar;15(3):305-18. doi: 10.1093/neuonc/nos313. Epub 2013 Jan 10.
88 Altered expression of lysosomal associated membrane protein 1 in esophageal squamous cell carcinoma.Pathol Res Pract. 2017 Aug;213(8):938-942. doi: 10.1016/j.prp.2017.05.008. Epub 2017 May 31.
89 Expression of oligodendroglial differentiation markers in pilocytic astrocytomas identifies two clinical subsets and shows a significant correlation with proliferation index and progression free survival.J Neurooncol. 2008 Jan;86(2):183-90. doi: 10.1007/s11060-007-9455-7. Epub 2007 Aug 10.
90 Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas.Cancer Res. 2010 Jan 15;70(2):512-9. doi: 10.1158/0008-5472.CAN-09-1851. Epub 2010 Jan 12.
91 Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas.Int J Cancer. 2008 Feb 15;122(4):807-15. doi: 10.1002/ijc.23189.
92 A multi-sequence and habitat-based MRI radiomics signature for preoperative prediction of MGMT promoter methylation in astrocytomas with prognostic implication.Eur Radiol. 2019 Feb;29(2):877-888. doi: 10.1007/s00330-018-5575-z. Epub 2018 Jul 23.
93 Elevated levels of p-Mnk1, p-eIF4E and p-p70S6K proteins are associated with tumor recurrence and poor prognosis in astrocytomas.J Neurooncol. 2017 Feb;131(3):485-493. doi: 10.1007/s11060-016-2327-2. Epub 2016 Nov 29.
94 Expression and tissue localization of membrane-type 1, 2, and 3 matrix metalloproteinases in human astrocytic tumors.Am J Pathol. 1999 Feb;154(2):417-28. doi: 10.1016/S0002-9440(10)65288-1.
95 Loss of MycBP may be associated with the improved survival in 1P co-deletion of lower grade glioma patients.Clin Neurol Neurosurg. 2018 Sep;172:112-115. doi: 10.1016/j.clineuro.2018.07.003. Epub 2018 Jul 5.
96 Innate immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1). J Neuroinflammation. 2012 Jan 2;9:1.
97 Clinical significance of CD133 and Nestin in astrocytic tumor: The correlation with pathological grade and survival.J Clin Lab Anal. 2020 Mar;34(3):e23082. doi: 10.1002/jcla.23082. Epub 2019 Nov 1.
98 Missense mutations in the NF2 gene result in the quantitative loss of merlin protein and minimally affect protein intrinsic function.Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4980-5. doi: 10.1073/pnas.1102198108. Epub 2011 Mar 7.
99 Transcriptional regulation of adrenomedullin by oncostatin M in human astroglioma cells: implications for tumor invasion and migration.Sci Rep. 2014 Sep 23;4:6444. doi: 10.1038/srep06444.
100 Investigation on 2',3'-O-Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists.ACS Med Chem Lett. 2018 Dec 26;10(4):493-498. doi: 10.1021/acsmedchemlett.8b00524. eCollection 2019 Apr 11.
101 Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure.Purinergic Signal. 2019 Mar;15(1):27-35. doi: 10.1007/s11302-019-09646-5. Epub 2019 Jan 25.
102 Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor.Br J Pharmacol. 1996 May;118(1):167-73. doi: 10.1111/j.1476-5381.1996.tb15381.x.
103 Alanine-(87)-threonine polymorphism impairs signaling and internalization of the human P2Y11 receptor, when co-expressed with the P2Y1 receptor.J Neurochem. 2014 May;129(4):602-13. doi: 10.1111/jnc.12666. Epub 2014 Feb 13.
104 Expression site of P2RY12 in residential microglial cells in astrocytomas correlates with M1 and M2 marker expression and tumor grade.Acta Neuropathol Commun. 2017 Jan 10;5(1):4. doi: 10.1186/s40478-016-0405-5.
105 Identification of competitive antagonists of the P2Y1 receptor. Mol Pharmacol. 1996 Nov;50(5):1323-9.
106 Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.Cancer Res. 1992 Jun 1;52(11):3213-9.
107 Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer.Cancer Res. 2002 May 1;62(9):2468-73.
108 PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma.Brain Pathol. 2013 Sep;23(5):565-73. doi: 10.1111/bpa.12043. Epub 2013 Mar 18.
109 Prognostic Value of PFKFB3 to PFKFB4 mRNA Ratio in Patients With Primary Glioblastoma (IDH-Wildtype).J Neuropathol Exp Neurol. 2019 Sep 1;78(9):865-870. doi: 10.1093/jnen/nlz067.
110 PKC and PKC activation regulates transcriptional activity and degradation of progesterone receptor in human astrocytoma cells.Endocrinology. 2015 Mar;156(3):1010-22. doi: 10.1210/en.2014-1137. Epub 2014 Dec 16.
111 A dangerous liaison: Leptin and sPLA2-IIA join forces to induce proliferation and migration of astrocytoma cells.PLoS One. 2017 Mar 1;12(3):e0170675. doi: 10.1371/journal.pone.0170675. eCollection 2017.
112 Cytosolic phospholipase A2 and the distinct transcriptional programs of astrocytoma cells.Trends Neurosci. 2000 Jun;23(6):259-64. doi: 10.1016/s0166-2236(00)01563-0.
113 Phospholipase C Beta 1: a Candidate Signature Gene for Proneural Subtype High-Grade Glioma.Mol Neurobiol. 2016 Nov;53(9):6511-6525. doi: 10.1007/s12035-015-9518-2. Epub 2015 Nov 28.
114 Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells. Biochim Biophys Acta. 2007 Dec;1773(12):1721-31.
115 PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.Cancer Res. 2009 Apr 1;69(7):2870-7. doi: 10.1158/0008-5472.CAN-08-2760. Epub 2009 Mar 17.
116 Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of -amyloid found in Alzheimer disease.BMC Neurosci. 2019 Feb 20;20(1):6. doi: 10.1186/s12868-019-0489-5.
117 Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB.J Neurochem. 2006 Feb;96(3):680-93. doi: 10.1111/j.1471-4159.2005.03599.x. Epub 2006 Jan 9.
118 Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.Sci Signal. 2015 Dec 8;8(406):ra125. doi: 10.1126/scisignal.aaa1690.
119 FAS associated phosphatase (FAP-1) blocks apoptosis of astrocytomas through dephosphorylation of FAS.J Neurooncol. 2005 Sep;74(3):241-8. doi: 10.1007/s11060-004-7202-x.
120 Functional comparison of long and short splice forms of RPTPbeta: implications for glioblastoma treatment.Neuro Oncol. 2005 Apr;7(2):154-63. doi: 10.1215/S1152851704000547.
121 Expression of Rac3 in human brain tumors.J Clin Neurosci. 2005 Jun;12(5):571-4. doi: 10.1016/j.jocn.2004.08.013.
122 Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma.J Neuropathol Exp Neurol. 2000 Sep;59(9):759-67. doi: 10.1093/jnen/59.9.759.
123 RIP2 promotes glioma cell growth by regulating TRAF3 and activating the NFB and p38 signaling pathways.Oncol Rep. 2018 Jun;39(6):2915-2923. doi: 10.3892/or.2018.6397. Epub 2018 Apr 23.
124 Expression of Nogo-66 receptor in human astrocytoma is correlated with tumor malignancy.Mol Biol Rep. 2012 Mar;39(3):2625-32. doi: 10.1007/s11033-011-1015-8. Epub 2011 Jun 18.
125 Serum amyloid A1 is upregulated in human glioblastoma.J Neurooncol. 2017 May;132(3):383-391. doi: 10.1007/s11060-017-2386-z. Epub 2017 Mar 11.
126 Inhibition of SUMO-specific protease 1 induces apoptosis of astroglioma cells by regulating NF-B/Akt pathways.Gene. 2016 Dec 31;595(2):175-179. doi: 10.1016/j.gene.2016.09.040. Epub 2016 Sep 28.
127 Expression of corticosteroid-binding globulin in human astrocytoma cell line.Cell Mol Neurobiol. 2009 Jun;29(4):583-8. doi: 10.1007/s10571-009-9350-1. Epub 2009 Jan 27.
128 Splice-site variant in ACSL5: a marker promoting opposing effect on cell viability and protein expression.Eur J Hum Genet. 2019 Dec;27(12):1836-1844. doi: 10.1038/s41431-019-0414-5. Epub 2019 May 3.
129 SIRP Alpha Protein Downregulates in Human Astrocytoma: Presumptive Involvement of Hsa-miR-520d-5p and Hsa-miR-520d-3p.Mol Neurobiol. 2017 Dec;54(10):8162-8169. doi: 10.1007/s12035-016-0302-8. Epub 2016 Nov 29.
130 The excitatory amino acid transporter-2 induces apoptosis and decreases glioma growth in vitro and in vivo.Cancer Res. 2005 Mar 1;65(5):1934-40. doi: 10.1158/0008-5472.CAN-04-3626.
131 Gamma-aminobutyric acid transporter (BGT-1) expressed in human astrocytoma U373 MG cells: pharmacological and molecular characterization and phorbol ester-induced inhibition.J Neurosci Res. 2002 Jul 1;69(1):125-32. doi: 10.1002/jnr.10258.
132 The role of LAT1 in (18)F-DOPA uptake in malignant gliomas.J Neurooncol. 2013 Jan;111(1):11-8. doi: 10.1007/s11060-012-0986-1. Epub 2012 Oct 20.
133 Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines.J Neuropathol Exp Neurol. 2005 Aug;64(8):695-705. doi: 10.1097/01.jnen.0000175329.59092.2c.
134 Estradiol increases cell growth in human astrocytoma cell lines through ER activation and its interaction with SRC-1 and SRC-3 coactivators.Biochim Biophys Acta. 2012 Feb;1823(2):379-86. doi: 10.1016/j.bbamcr.2011.11.004. Epub 2011 Nov 21.
135 Expression profiling of glycosyltransferases and related enzymes using in situ hybridization.Methods Enzymol. 2006;416:120-9. doi: 10.1016/S0076-6879(06)16008-5.
136 Ketamine suppresses the substance P-induced production of IL-6 and IL-8 by human U373MG glioblastoma/astrocytoma cells.Int J Mol Med. 2017 Mar;39(3):687-692. doi: 10.3892/ijmm.2017.2875. Epub 2017 Feb 3.
137 Homologous desensitization of thromboxane A2 receptor in 1321N1 human astrocytoma cells.J Pharmacol Exp Ther. 1996 Feb;276(2):829-36.
138 Plasmatic membrane toll-like receptor expressions in human astrocytomas.PLoS One. 2018 Jun 18;13(6):e0199211. doi: 10.1371/journal.pone.0199211. eCollection 2018.
139 Death Receptor 6 (DR6) Is Overexpressed in Astrocytomas.Anticancer Res. 2019 May;39(5):2299-2306. doi: 10.21873/anticanres.13346.
140 Biological Functions of TNKS1 and Its Relationship with Wnt/-Catenin Pathway in Astrocytoma.Onco Targets Ther. 2019 Dec 11;12:10841-10850. doi: 10.2147/OTT.S206142. eCollection 2019.
141 Distinct roles of Topoisomerase II isoforms: DNA damage accelerating alpha, double strand break repair promoting beta.Arch Biochem Biophys. 2008 Feb 1;470(1):27-34. doi: 10.1016/j.abb.2007.10.017. Epub 2007 Nov 1.
142 Expression of TRH and TRH-like peptides in a human glioblastoma-astrocytoma cell line (U-373-MG).J Endocrinol. 2000 Sep;166(3):697-703. doi: 10.1677/joe.0.1660697.
143 Myc down-regulation affects cyclin D1/cdk4 activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell line.Cell Prolif. 2009 Feb;42(1):94-109. doi: 10.1111/j.1365-2184.2008.00576.x.
144 Expression of vascular endothelial growth factor-b in human astrocytoma.Neuro Oncol. 2000 Apr;2(2):80-6. doi: 10.1093/neuonc/2.2.80.
145 Refined deletion mapping of the chromosome 19q glioma tumor suppressor gene to the D19S412-STD interval.Oncogene. 1996 Dec 5;13(11):2483-5.
146 High expression of the stem cell marker nestin is an adverse prognostic factor in WHO grade II-III astrocytomas and oligoastrocytomas.J Neurooncol. 2014 Mar;117(1):183-189. doi: 10.1007/s11060-014-1376-7. Epub 2014 Feb 12.
147 Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms.PLoS One. 2019 Sep 6;14(9):e0221952. doi: 10.1371/journal.pone.0221952. eCollection 2019.
148 High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.Oncogene. 2008 Aug 7;27(34):4745-51. doi: 10.1038/onc.2008.110. Epub 2008 Apr 14.
149 Expression and clinicopathological significance of Nck1 in human astrocytoma progression.Int J Neurosci. 2019 Feb;129(2):171-178. doi: 10.1080/00207454.2018.1516655. Epub 2018 Nov 22.
150 NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape.Sci Rep. 2015 Nov 12;5:16495. doi: 10.1038/srep16495.
151 Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8.Cancer Res. 2005 May 1;65(9):3617-23. doi: 10.1158/0008-5472.CAN-05-0048.
152 Protein tyrosine phosphatase mu regulates glioblastoma cell growth and survival in vivo.Neuro Oncol. 2012 May;14(5):561-73. doi: 10.1093/neuonc/nos066. Epub 2012 Apr 14.
153 Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci.Cancer Res. 1995 Oct 1;55(19):4237-9.
154 Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.Nat Commun. 2014 Nov 25;5:5582. doi: 10.1038/ncomms6582.
155 Glutathione S-transferase polymorphisms and survival in primary malignant glioma.Clin Cancer Res. 2004 Apr 15;10(8):2618-25. doi: 10.1158/1078-0432.ccr-03-0053.
156 Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival.Sci Rep. 2019 Apr 1;9(1):5406. doi: 10.1038/s41598-019-41974-9.
157 Diagnostic revision of 206 adult gliomas (including 40 oligoastrocytomas) based on ATRX, IDH1/2 and 1p/19q status.J Neurooncol. 2017 Jan;131(2):213-222. doi: 10.1007/s11060-016-2296-5. Epub 2016 Oct 28.
158 Initial studies to define the physiologic role of cN-II.Nucleosides Nucleotides Nucleic Acids. 2011 Dec;30(12):1155-60. doi: 10.1080/15257770.2011.628355.
159 Interferon gamma up-regulates alpha 2 macroglobulin expression in human astrocytoma cells.J Neuroimmunol. 1994 Aug;53(1):31-7. doi: 10.1016/0165-5728(94)90061-2.
160 ADAR RNA editing in human disease; more to it than meets the I.Hum Genet. 2017 Sep;136(9):1265-1278. doi: 10.1007/s00439-017-1837-0. Epub 2017 Sep 14.
161 Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma.J Biol Chem. 2017 Mar 10;292(10):4326-4335. doi: 10.1074/jbc.M117.779868. Epub 2017 Feb 6.
162 Expression of activating transcription factor 5 (ATF5) is increased in astrocytomas of different WHO grades and correlates with survival of glioblastoma patients.Onco Targets Ther. 2018 Dec 4;11:8673-8684. doi: 10.2147/OTT.S176549. eCollection 2018.
163 A large de novo 9p21.3 deletion in a girl affected by astrocytoma and multiple melanoma.BMC Med Genet. 2014 May 17;15:59. doi: 10.1186/1471-2350-15-59.
164 High CHI3L1 expression is associated with glioma patient survival.Diagn Pathol. 2016 Apr 27;11:42. doi: 10.1186/s13000-016-0492-4.
165 Identification of a novel gene product, RIG, that is down-regulated in human glioblastoma.Oncogene. 1997 Mar 6;14(9):1075-81. doi: 10.1038/sj.onc.1200925.
166 DMBT1 homozygous deletion in diffuse astrocytomas is associated with unfavorable clinical outcome.J Neuropathol Exp Neurol. 2012 Aug;71(8):702-7. doi: 10.1097/NEN.0b013e31825f2e5d.
167 Region-Specific Dok2 Overexpression Associates with Poor Prognosis in Human Astrocytoma.Mol Neurobiol. 2018 Jan;55(1):402-408. doi: 10.1007/s12035-016-0324-2. Epub 2016 Dec 14.
168 LINC00470 Coordinates the Epigenetic Regulation of ELFN2 to Distract GBM Cell Autophagy.Mol Ther. 2018 Sep 5;26(9):2267-2281. doi: 10.1016/j.ymthe.2018.06.019. Epub 2018 Jun 27.
169 Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients.Tumour Biol. 2017 Apr;39(4):1010428317694552. doi: 10.1177/1010428317694552.
170 Overexpression and Nucleolar Localization of -Tubulin Small Complex Proteins GCP2 and GCP3 in Glioblastoma.J Neuropathol Exp Neurol. 2015 Jul;74(7):723-42. doi: 10.1097/NEN.0000000000000212.
171 Hydrogen sulfide generation from l-cysteine in the human glioblastoma-astrocytoma U-87 MG and neuroblastoma SHSY5Y cell lines.Acta Biochim Pol. 2017;64(1):171-176. doi: 10.18388/abp.2016_1394. Epub 2017 Mar 14.
172 Quantitative analysis of F-actin redistribution in astrocytoma cells treated with candidate pharmaceuticals.Cytometry A. 2014 Jun;85(6):512-21. doi: 10.1002/cyto.a.22442. Epub 2014 Feb 11.
173 Epigenetic silencing of the protocadherin family member PCDH-gamma-A11 in astrocytomas.Neoplasia. 2005 Mar;7(3):193-9. doi: 10.1593/neo.04490.
174 Overexpression of mTOR and p(240-244)S6 in IDH1 Wild-Type Human Glioblastomas Is Predictive of Low Survival.J Histochem Cytochem. 2018 Jun;66(6):403-414. doi: 10.1369/0022155417750838. Epub 2018 Jan 12.
175 Static and dynamic (18)F-FET PET for the characterization of gliomas defined by IDH and 1p/19q status.Eur J Nucl Med Mol Imaging. 2018 Mar;45(3):443-451. doi: 10.1007/s00259-017-3846-6. Epub 2017 Oct 17.
176 Shc3 affects human high-grade astrocytomas survival.Oncogene. 2005 Aug 4;24(33):5198-206. doi: 10.1038/sj.onc.1208708.
177 Expression of the tumor necrosis factor receptor-associated factors 1 and 2 and regulation of the nuclear factor-kappaB antiapoptotic activity in human gliomas.J Neurosurg. 2005 Nov;103(5):873-81. doi: 10.3171/jns.2005.103.5.0873.
178 Tbx2 confers poor prognosis in glioblastoma and promotes temozolomide resistance with change of mitochondrial dynamics.Onco Targets Ther. 2017 Feb 20;10:1059-1069. doi: 10.2147/OTT.S124012. eCollection 2017.
179 Frequent gene amplification and overexpression of decoy receptor 3 in glioblastoma.Acta Neuropathol. 2005 Mar;109(3):294-8. doi: 10.1007/s00401-004-0956-6. Epub 2004 Dec 31.
180 Deep phenotyping of patients with Tuberous Sclerosis Complex and no mutation identified in TSC1 and TSC2.Eur J Med Genet. 2018 Jul;61(7):403-410. doi: 10.1016/j.ejmg.2018.02.005. Epub 2018 Feb 9.
181 Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction.Int J Cancer. 2006 Nov 15;119(10):2330-8. doi: 10.1002/ijc.22108.
182 Attractin is elevated in the cerebrospinal fluid of patients with malignant astrocytoma and mediates glioma cell migration.Clin Cancer Res. 2006 Nov 1;12(21):6331-6. doi: 10.1158/1078-0432.CCR-06-1296.
183 Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes.J Neuropathol Exp Neurol. 2008 Dec;67(12):1194-204. doi: 10.1097/NEN.0b013e31818fbe1e.
184 Cdk9 regulates neural differentiation and its expression correlates with the differentiation grade of neuroblastoma and PNET tumors. Cancer Biol Ther. 2005 Mar;4(3):277-81. doi: 10.4161/cbt.4.3.1497. Epub 2005 Mar 20.
185 Inhibition of KIF14 Suppresses Tumor Cell Growth and Promotes Apoptosis in Human Glioblastoma.Cell Physiol Biochem. 2015;37(5):1659-70. doi: 10.1159/000438532. Epub 2015 Nov 5.
186 Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. Neurosci Res. 2006 Dec;56(4):450-8. doi: 10.1016/j.neures.2006.09.006. Epub 2006 Oct 17.
187 Matrilin-2 expression distinguishes clinically relevant subsets of pilocytic astrocytoma.Neurology. 2006 Jan 10;66(1):127-30. doi: 10.1212/01.wnl.0000188667.66646.1c.
188 Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers.BMC Genet. 2004 Sep 2;5:27. doi: 10.1186/1471-2156-5-27.
189 Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells.Exp Cell Res. 2010 Apr 15;316(7):1137-47. doi: 10.1016/j.yexcr.2010.02.011. Epub 2010 Feb 12.
190 ADAM 12: a putative marker of oligodendrogliomas?.Dis Markers. 2013;34(2):81-91. doi: 10.3233/DMA-120953.
191 GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion.Oncogene. 2005 Mar 3;24(10):1673-82. doi: 10.1038/sj.onc.1208395.
192 Differential expression of the tumor suppressor A-kinase anchor protein 12 in human diffuse and pilocytic astrocytomas is regulated by promoter methylation.J Neuropathol Exp Neurol. 2013 Oct;72(10):933-41. doi: 10.1097/NEN.0b013e3182a59a88.
193 Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells.Nat Med. 1995 Jul;1(7):638-43. doi: 10.1038/nm0795-638.
194 Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors.BMC Cancer. 2018 May 23;18(1):584. doi: 10.1186/s12885-018-4493-4.
195 Silver nanoparticle-induced hormesis of astroglioma cells: A Mu-2-related death-inducing protein-orchestrated modus operandi.Int J Biol Macromol. 2018 Oct 1;117:1147-1156. doi: 10.1016/j.ijbiomac.2018.05.234. Epub 2018 Jun 2.
196 Gene expression analyses of grade II gliomas and identification of rPTPbeta/zeta as a candidate oligodendroglioma marker.Neuro Oncol. 2008 Feb;10(1):2-9. doi: 10.1215/15228517-2007-041. Epub 2007 Nov 14.
197 The value of multi ultrahigh-b-value DWI in grading cerebral astrocytomas and its association with aquaporin-4.Br J Radiol. 2018 Jun;91(1086):20170696. doi: 10.1259/bjr.20170696. Epub 2018 Mar 20.
198 Expression of aquaporin8 in human astrocytomas: correlation with pathologic grade.Biochem Biophys Res Commun. 2013 Oct 11;440(1):168-72. doi: 10.1016/j.bbrc.2013.09.057. Epub 2013 Sep 18.
199 Aberrant nuclear factor-kappaB activity and its participation in the growth of human malignant astrocytoma.J Neurosurg. 2002 May;96(5):909-17. doi: 10.3171/jns.2002.96.5.0909.
200 Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.J Neuropathol Exp Neurol. 2006 Dec;65(12):1149-56. doi: 10.1097/01.jnen.0000248543.90304.2b.
201 ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties.Exp Cell Res. 2008 Sep 10;314(15):2870-83. doi: 10.1016/j.yexcr.2008.06.017. Epub 2008 Jul 1.
202 KUB3 amplification and overexpression in human gliomas.Glia. 2001 Oct;36(1):1-10. doi: 10.1002/glia.1090.
203 An update on the central nervous system manifestations of neurofibromatosis type 1.Acta Neuropathol. 2020 Apr;139(4):625-641. doi: 10.1007/s00401-019-02002-2. Epub 2019 Apr 8.
204 Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas.BMC Cancer. 2009 Aug 4;9:268. doi: 10.1186/1471-2407-9-268.
205 Human BLCAP transcript: new editing events in normal and cancerous tissues.Int J Cancer. 2010 Jul 1;127(1):127-37. doi: 10.1002/ijc.25022.
206 Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma.Oncol Rep. 2005 Feb;13(2):335-40.
207 Mislocalization of the E3 ligase, -transducin repeat-containing protein 1 (-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.J Biol Chem. 2011 Jun 3;286(22):19777-88. doi: 10.1074/jbc.M111.237081. Epub 2011 Mar 28.
208 Production and interferon-gamma-mediated regulation of complement component C2 and factors B and D by the astroglioma cell line U105-MG.Biochem J. 1992 Oct 15;287 ( Pt 2)(Pt 2):595-601. doi: 10.1042/bj2870595.
209 Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene.Clin Cancer Res. 2005 Feb 1;11(3):1119-28.
210 Characterization of a novel anti-cancer compound for astrocytomas.PLoS One. 2014 Sep 25;9(9):e108166. doi: 10.1371/journal.pone.0108166. eCollection 2014.
211 CCNG2 Overexpression Mediated by AKT Inhibits Tumor Cell Proliferation in Human Astrocytoma Cells.Front Neurol. 2018 Apr 18;9:255. doi: 10.3389/fneur.2018.00255. eCollection 2018.
212 Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas.BMC Cancer. 2018 Mar 9;18(1):270. doi: 10.1186/s12885-018-4179-y.
213 Elevated expression of the C-type lectin CD93 in the glioblastoma vasculature regulates cytoskeletal rearrangements that enhance vessel function and reduce host survival.Cancer Res. 2015 Nov 1;75(21):4504-16. doi: 10.1158/0008-5472.CAN-14-3636. Epub 2015 Sep 11.
214 CD99 Expression in Glioblastoma Molecular Subtypes and Role in Migration and Invasion.Int J Mol Sci. 2019 Mar 6;20(5):1137. doi: 10.3390/ijms20051137.
215 ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis.Oncogene. 2013 Feb 21;32(8):998-1009. doi: 10.1038/onc.2012.125. Epub 2012 Apr 23.
216 Cdk5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock.J Cell Sci. 2001 Mar;114(Pt 6):1145-53. doi: 10.1242/jcs.114.6.1145.
217 Differential expression of centrosome-associated proteins in human brain tumors: a possible role of hNinein isoform 6 in cell differentiation.Biofactors. 2012 Nov-Dec;38(6):470-7. doi: 10.1002/biof.1053. Epub 2012 Oct 10.
218 Molecular Diagnostics of Gliomas Using Next Generation Sequencing of a Glioma-Tailored Gene Panel.Brain Pathol. 2017 Mar;27(2):146-159. doi: 10.1111/bpa.12367. Epub 2016 Apr 19.
219 IL-1 beta inhibits IFN-gamma-induced class II MHC expression by suppressing transcription of the class II transactivator gene.J Immunol. 1999 Jan 15;162(2):886-96.
220 Mutational analysis of the CITED4 gene in glioblastomas.Cancer Genet Cytogenet. 2008 Sep;185(2):114-6. doi: 10.1016/j.cancergencyto.2008.05.013.
221 Identification of COL6A1 as a differentially expressed gene in human astrocytomas.Genet Mol Res. 2008 Apr 22;7(2):371-8. doi: 10.4238/vol7-2gmr432.
222 CASC2c as an unfavorable prognosis factor interacts with miR-101 to mediate astrocytoma tumorigenesis.Cell Death Dis. 2017 Mar 2;8(3):e2639. doi: 10.1038/cddis.2017.11.
223 Expression of N-cadherin and alpha-catenin in astrocytomas and glioblastomas.Br J Cancer. 1995 Sep;72(3):627-33. doi: 10.1038/bjc.1995.384.
224 Doublecortin is preferentially expressed in invasive human brain tumors.Acta Neuropathol. 2005 Nov;110(5):472-80. doi: 10.1007/s00401-005-1070-0. Epub 2005 Sep 30.
225 Desmoplastic Infantile Ganglioglioma: A MAPK Pathway-Driven and Microglia/Macrophage-Rich Neuroepithelial Tumor.J Neuropathol Exp Neurol. 2019 Nov 1;78(11):1011-1021. doi: 10.1093/jnen/nlz086.
226 Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach.Neuroradiology. 2019 May;61(5):545-555. doi: 10.1007/s00234-019-02173-5. Epub 2019 Feb 2.
227 Different behaviour of DVL1, DVL2, DVL3 in astrocytoma malignancy grades and their association to TCF1 and LEF1 upregulation.J Cell Mol Med. 2019 Jan;23(1):641-655. doi: 10.1111/jcmm.13969. Epub 2018 Nov 23.
228 The E2F-family proteins induce distinct cell cycle regulatory factors in p16-arrested, U343 astrocytoma cells.Oncogene. 1998 Aug 20;17(7):867-76. doi: 10.1038/sj.onc.1202008.
229 c-erbB-2 in astrocytomas: infrequent overexpression by immunohistochemistry and absence of gene amplification by fluorescence in situ hybridization.Br J Cancer. 1996 Mar;73(5):620-3. doi: 10.1038/bjc.1996.107.
230 hHSS1: a novel secreted factor and suppressor of glioma growth located at chromosome 19q13.33.J Neurooncol. 2011 Apr;102(2):197-211. doi: 10.1007/s11060-010-0314-6. Epub 2010 Jul 31.
231 DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in Human Gliomas.Brain Pathol. 2007 Oct;17(4):363-70. doi: 10.1111/j.1750-3639.2007.00083.x. Epub 2007 Jul 4.
232 Circulating microRNAs as Biomarkers for Pediatric Astrocytomas.Arch Med Res. 2017 May;48(4):323-332. doi: 10.1016/j.arcmed.2017.07.002.
233 BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions.Brain Behav Immun. 2011 Nov;25(8):1554-68. doi: 10.1016/j.bbi.2011.05.003. Epub 2011 May 17.
234 miR-106a-5p inhibits the proliferation and migration of astrocytoma cells and promotes apoptosis by targeting FASTK.PLoS One. 2013 Aug 27;8(8):e72390. doi: 10.1371/journal.pone.0072390. eCollection 2013.
235 Post-transcriptional regulation of fukutin in an astrocytoma cell line.Int J Exp Pathol. 2012 Feb;93(1):46-55. doi: 10.1111/j.1365-2613.2011.00799.x.
236 Overexpression of Fli-1 in astrocytoma is associated with poor prognosis.Oncotarget. 2017 Apr 25;8(17):29174-29186. doi: 10.18632/oncotarget.16303.
237 FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas.Acta Neuropathol. 2020 Jan;139(1):175-192. doi: 10.1007/s00401-019-02067-z. Epub 2019 Aug 31.
238 Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.Oncotarget. 2012 Jul;3(7):709-22. doi: 10.18632/oncotarget.588.
239 Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: an index of malignancy in astrocytomas.Int J Oncol. 2003 May;22(5):1045-9.
240 Differential expression of nucleostemin, a stem cell marker, and its variants in different types of brain tumors.Mol Carcinog. 2010 Sep;49(9):818-25. doi: 10.1002/mc.20658.
241 Expression of the Golgi phosphoprotein-3 gene in human gliomas: a pilot study.J Neurooncol. 2011 Nov;105(2):159-63. doi: 10.1007/s11060-011-0573-x. Epub 2011 Apr 16.
242 Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades.Oncogene. 2018 Aug;37(31):4313-4333. doi: 10.1038/s41388-018-0277-1. Epub 2018 May 3.
243 IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO.Acta Neuropathol. 2015 Jun;129(6):867-73. doi: 10.1007/s00401-015-1438-8. Epub 2015 May 12.
244 Bithalamic gliomas may be molecularly distinct from their unilateral high-grade counterparts.Brain Pathol. 2018 Jan;28(1):112-120. doi: 10.1111/bpa.12484. Epub 2017 Mar 12.
245 Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas.BMC Cancer. 2018 Jun 18;18(1):664. doi: 10.1186/s12885-018-4569-1.
246 Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3-E2F1 Axis Linking Reversely with Survival in Gliomas.Theranostics. 2017 Jan 1;7(1):132-143. doi: 10.7150/thno.17032. eCollection 2017.
247 Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells.Mol Cell Biochem. 2008 Jan;307(1-2):101-8. doi: 10.1007/s11010-007-9589-0. Epub 2007 Sep 12.
248 HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation.Oncogene. 2012 Mar 8;31(10):1299-310. doi: 10.1038/onc.2011.316. Epub 2011 Jul 25.
249 HFE polymorphisms affect cellular glutamate regulation.Neurobiol Aging. 2011 Jun;32(6):1114-23. doi: 10.1016/j.neurobiolaging.2009.05.016. Epub 2009 Jun 26.
250 Expression of iron-related genes in human brain and brain tumors.BMC Neurosci. 2009 Apr 22;10:36. doi: 10.1186/1471-2202-10-36.
251 Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells.Mol Cancer. 2011 May 22;10:60. doi: 10.1186/1476-4598-10-60.
252 Frequent HRK inactivation associated with low apoptotic index in secondary glioblastomas.Acta Neuropathol. 2005 Oct;110(4):402-10. doi: 10.1007/s00401-005-1065-x. Epub 2005 Sep 10.
253 Differential expression of ID4 and its association with TP53 mutation, SOX2, SOX4 and OCT-4 expression levels.PLoS One. 2013 Apr 16;8(4):e61605. doi: 10.1371/journal.pone.0061605. Print 2013.
254 Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN--phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.Brain Res. 2017 Mar 1;1658:60-67. doi: 10.1016/j.brainres.2017.01.018. Epub 2017 Jan 19.
255 ISG54 and ISG56 are induced by TLR3 signaling in U373MG human astrocytoma cells: possible involvement in CXCL10 expression.Neurosci Res. 2014 Jul;84:34-42. doi: 10.1016/j.neures.2014.03.001. Epub 2014 Mar 11.
256 Insulin like growth factor binding protein 4 promotes GBM progression and regulates key factors involved in EMT and invasion.J Neurooncol. 2014 Feb;116(3):455-64. doi: 10.1007/s11060-013-1324-y. Epub 2014 Jan 7.
257 Loss of inhibitor of growth (ING-4) is implicated in the pathogenesis and progression of human astrocytomas.Brain Pathol. 2010 Mar;20(2):490-7. doi: 10.1111/j.1750-3639.2009.00325.x. Epub 2009 Aug 6.
258 Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma.BMC Cancer. 2004 Sep 14;4:65. doi: 10.1186/1471-2407-4-65.
259 HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma.Oncotarget. 2017 Jul 22;8(40):68415-68438. doi: 10.18632/oncotarget.19474. eCollection 2017 Sep 15.
260 Epigenetic silencing of KAZALD1 confers a better prognosis and is associated with malignant transformation/progression in glioma.Oncol Rep. 2013 Nov;30(5):2089-96. doi: 10.3892/or.2013.2706. Epub 2013 Aug 29.
261 Overexpression of mouse IsK protein fused to green fluorescent protein induces apoptosis of human astroglioma cells.Neurol Res. 2007 Sep;29(6):628-31. doi: 10.1179/016164107X166326.
262 Analysis of KIAA1549-BRAF fusion gene expression and IDH1/IDH2 mutations in low grade pediatric astrocytomas.J Neurooncol. 2014 Apr;117(2):235-42. doi: 10.1007/s11060-014-1398-1. Epub 2014 Feb 17.
263 Absence of mutation in the putative tumor-suppressor gene KLF6 in colorectal cancers.Oncogene. 2005 Nov 3;24(48):7253-6. doi: 10.1038/sj.onc.1208867.
264 Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas.J Neurooncol. 2012 Sep;109(3):545-53. doi: 10.1007/s11060-012-0924-2. Epub 2012 Jul 7.
265 The IE2 regulatory protein of human cytomegalovirus induces expression of the human transforming growth factor beta1 gene through an Egr-1 binding site.J Virol. 1996 Oct;70(10):7062-70. doi: 10.1128/JVI.70.10.7062-7070.1996.
266 Expression of the LGI1 gene product in astrocytic gliomas: downregulation with malignant progression.Virchows Arch. 2003 Oct;443(4):561-4. doi: 10.1007/s00428-003-0874-3. Epub 2003 Aug 26.
267 Real-time quantitative PCR analysis of regions involved in gene amplification reveals gene overdose in low-grade astrocytic gliomas.Diagn Mol Pathol. 2005 Dec;14(4):224-9. doi: 10.1097/01.pas.0000177799.58336.1a.
268 Markers of mRNA stabilization and degradation, and RNAi within astrocytoma GW bodies.J Neurosci Res. 2007 Dec;85(16):3619-31. doi: 10.1002/jnr.21439.
269 Cytomegalovirus-mediated induction of antisense mRNA expression to UL44 inhibits virus replication in an astrocytoma cell line: identification of an essential gene.J Virol. 1995 Apr;69(4):2047-57. doi: 10.1128/JVI.69.4.2047-2057.1995.
270 Oligo-astrocytoma in LZTR1-related Noonan syndrome.Eur J Med Genet. 2020 Jan;63(1):103617. doi: 10.1016/j.ejmg.2019.01.007. Epub 2019 Jan 19.
271 Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis.Neuro Oncol. 2013 Dec;15(12):1696-709. doi: 10.1093/neuonc/not136. Epub 2013 Nov 11.
272 Hydrogel Environment Supports Cell Culture Expansion of a Grade IV Astrocytoma.Neurochem Res. 2017 Sep;42(9):2610-2624. doi: 10.1007/s11064-017-2308-7. Epub 2017 Jun 7.
273 Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors.Cancer. 2004 Sep 1;101(5):1018-27. doi: 10.1002/cncr.20442.
274 Megalencephalic Leukoencephalopathy with Subcortical Cysts Protein-1 (MLC1) Counteracts Astrocyte Activation in Response to Inflammatory Signals.Mol Neurobiol. 2019 Dec;56(12):8237-8254. doi: 10.1007/s12035-019-01657-y. Epub 2019 Jun 17.
275 Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells.J Neuropathol Exp Neurol. 2010 Mar;69(3):215-23. doi: 10.1097/NEN.0b013e3181ce9f67.
276 High MMP-26 expression in glioma is correlated with poor clinical outcome of patients.Oncol Lett. 2018 Aug;16(2):2237-2242. doi: 10.3892/ol.2018.8880. Epub 2018 Jun 4.
277 Comparative genomic hybridization in glioma: a meta-analysis of 509 cases.Cancer Genet Cytogenet. 2002 Jun;135(2):147-59. doi: 10.1016/s0165-4608(01)00650-1.
278 Quantitative PCR analysis of the expression profile of genes related to multiple drug resistance in tumors of the central nervous system.J Neurooncol. 2007 Oct;85(1):1-10. doi: 10.1007/s11060-007-9382-7. Epub 2007 Apr 12.
279 Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.Acta Neuropathol. 2020 Jan;139(1):193-209. doi: 10.1007/s00401-019-02078-w. Epub 2019 Sep 28.
280 Expression of a NOS-III-like protein in human astroglial cell culture.Biochem Biophys Res Commun. 1998 Nov 27;252(3):552-5. doi: 10.1006/bbrc.1998.9691.
281 Genomic organization, chromosomal localization and regulation of expression of the neuronal nuclear matrix protein NRP/B in human brain tumors.Gene. 2000 Sep 5;255(1):105-16. doi: 10.1016/s0378-1119(00)00297-3.
282 Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma.Cancer Res. 2007 Jan 1;67(1):130-8. doi: 10.1158/0008-5472.CAN-06-2478.
283 Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes.J Mol Biol. 2006 Feb 3;355(5):898-910. doi: 10.1016/j.jmb.2005.11.026. Epub 2005 Nov 28.
284 Expression and prognostic value of NDRG2 in human astrocytomas.J Neurol Sci. 2011 Sep 15;308(1-2):77-82. doi: 10.1016/j.jns.2011.06.007. Epub 2011 Jun 25.
285 Differences between phosphotyrosine accumulation and Neu/ErbB-2 receptor expression in astrocytic proliferative processes. Implications for glial oncogenesis.Cancer. 1996 Sep 15;78(6):1272-83. doi: 10.1002/(SICI)1097-0142(19960915)78:6<1272::AID-CNCR16>3.0.CO;2-Y.
286 NFAT4 is expressed in primary astrocytes and activated by glutamate.J Neurosci Res. 2003 Apr 15;72(2):191-7. doi: 10.1002/jnr.10584.
287 Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma.J Neurooncol. 2020 Jan;146(1):41-53. doi: 10.1007/s11060-019-03352-3. Epub 2019 Nov 23.
288 Upregulation of the NLRC4 inflammasome contributes to poor prognosis in glioma patients.Sci Rep. 2019 May 27;9(1):7895. doi: 10.1038/s41598-019-44261-9.
289 MiR-181b-5p downregulates NOVA1 to suppress proliferation, migration and invasion and promote apoptosis in astrocytoma.PLoS One. 2014 Oct 9;9(10):e109124. doi: 10.1371/journal.pone.0109124. eCollection 2014.
290 NPAS3 demonstrates features of a tumor suppressive role in driving the progression of Astrocytomas.Am J Pathol. 2011 Jul;179(1):462-76. doi: 10.1016/j.ajpath.2011.03.044. Epub 2011 May 19.
291 Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice.Brain Behav Immun. 2019 May;78:116-130. doi: 10.1016/j.bbi.2019.01.014. Epub 2019 Jan 22.
292 Prognostic Role of Chicken Ovalbumin Upstream Promoter Transcription Factor II in Isocitrate Dehydrogenase-Mutant Glioma with 1p19q Co-Deletion.J Mol Neurosci. 2019 Jun;68(2):234-242. doi: 10.1007/s12031-019-01281-4. Epub 2019 Mar 30.
293 Fragile X mental retardation protein promotes astrocytoma proliferation via the MEK/ERK signaling pathway.Oncotarget. 2016 Nov 15;7(46):75394-75406. doi: 10.18632/oncotarget.12215.
294 Nucleolar and spindle associated protein 1 promotes the aggressiveness of astrocytoma by activating the Hedgehog signaling pathway.J Exp Clin Cancer Res. 2017 Sep 12;36(1):127. doi: 10.1186/s13046-017-0597-y.
295 SOX10 and Olig2 as negative markers for the diagnosis of ependymomas: An immunohistochemical study of 98 glial tumors.Histol Histopathol. 2016 Jan;31(1):95-102. doi: 10.14670/HH-11-654. Epub 2015 Aug 19.
296 Novel small molecule protein kinase CK2 inhibitors exert potent antitumor effects on T98G and SEGA cells in vitro.Folia Neuropathol. 2019;57(3):239-248. doi: 10.5114/fn.2019.88452.
297 MicroRNA-132 targets PEA-15 and suppresses the progression of astrocytoma in vitro.J Neurooncol. 2016 Sep;129(2):211-20. doi: 10.1007/s11060-016-2173-2. Epub 2016 Jun 13.
298 Phosphoglycerate mutase 1 is highly expressed in C6 glioma cells and human astrocytoma.Oncol Lett. 2018 Jun;15(6):8935-8940. doi: 10.3892/ol.2018.8477. Epub 2018 Apr 12.
299 Glioma-expressed antigen 2 (GLEA2): a novel protein that can elicit immune responses in glioblastoma patients and some controls.Clin Exp Immunol. 2001 Nov;126(2):206-13. doi: 10.1046/j.1365-2249.2001.01635.x.
300 PHF3 expression is frequently reduced in glioma.Cytogenet Cell Genet. 2001;94(3-4):131-6. doi: 10.1159/000048804.
301 PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.Clin Cancer Res. 2014 Feb 15;20(4):827-36. doi: 10.1158/1078-0432.CCR-13-2053. Epub 2013 Dec 3.
302 Analysis of proliferation and apoptosis in brain gliomas: prognostic and clinical value.J Neurooncol. 1999;44(3):255-66. doi: 10.1023/a:1006398613605.
303 Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease.Am J Pathol. 2006 Mar;168(3):888-97. doi: 10.2353/ajpath.2006.051028.
304 Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression.Mol Cell Biol. 2011 Mar;31(6):1225-39. doi: 10.1128/MCB.00607-10. Epub 2011 Jan 18.
305 Expression of oligodendrocyte-associated genes in cell lines derived from human gliomas and neuroblastomas.Cancer Res. 1993 Jan 1;53(1):170-5.
306 Spermassociated antigen 9 promotes astrocytoma cell invasion through the upregulation of podocalyxin.Mol Med Rep. 2014 Jul;10(1):417-22. doi: 10.3892/mmr.2014.2168. Epub 2014 Apr 24.
307 iASPP, a microRNA?24 target, is aberrantly expressed in astrocytoma and regulatesmalignantgliomacellmigration and viability.Mol Med Rep. 2018 Jan;17(1):1970-1978. doi: 10.3892/mmr.2017.8097. Epub 2017 Nov 15.
308 STAT3 inhibitors attenuate interferon--induced neurotoxicity and inflammatory molecule production by human astrocytes.Neurobiol Dis. 2011 Feb;41(2):299-307. doi: 10.1016/j.nbd.2010.09.018. Epub 2010 Oct 1.
309 miR-101 reverses hypomethylation of the PRDM16 promoter to disrupt mitochondrial function in astrocytoma cells.Oncotarget. 2016 Jan 26;7(4):5007-22. doi: 10.18632/oncotarget.6652.
310 Altered cellular distribution and sub-cellular sorting of doppel (Dpl) protein in human astrocytoma cell lines.Cell Oncol. 2008;30(4):337-47. doi: 10.3233/clo-2008-0429.
311 PROX1 promotes human glioblastoma cell proliferation and invasion via activation of the nuclear factor-B signaling pathway.Mol Med Rep. 2017 Feb;15(2):963-968. doi: 10.3892/mmr.2016.6075. Epub 2016 Dec 27.
312 Expression of the pro-apoptotic protein ARTS in astrocytic tumors: correlation with malignancy grade and survival rate.Cancer. 2004 Dec 1;101(11):2614-21. doi: 10.1002/cncr.20675.
313 Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas.J Neuropathol Exp Neurol. 2003 Dec;62(12):1265-75. doi: 10.1093/jnen/62.12.1265.
314 Rab23 is overexpressed in human astrocytoma and promotes cell migration and invasion through regulation of Rac1.Tumour Biol. 2016 Aug;37(8):11049-55. doi: 10.1007/s13277-016-4949-6. Epub 2016 Feb 20.
315 Hypomethylated Rab27b is a progression-associated prognostic biomarker of glioma regulating MMP-9 to promote invasion.Oncol Rep. 2015 Sep;34(3):1503-9. doi: 10.3892/or.2015.4125. Epub 2015 Jul 13.
316 Rac2 expression and mutation in human brain tumors.Acta Neurochir (Wien). 2005 May;147(5):551-4; discussion 554. doi: 10.1007/s00701-005-0515-5. Epub 2005 Apr 4.
317 Overexpression of RASD1 inhibits glioma cell migration/invasion and inactivates the AKT/mTOR signaling pathway.Sci Rep. 2017 Jun 9;7(1):3202. doi: 10.1038/s41598-017-03612-0.
318 miR-137 acts as a tumor suppressor in astrocytoma by targeting RASGRF1.Tumour Biol. 2016 Mar;37(3):3331-40. doi: 10.1007/s13277-015-4110-y. Epub 2015 Oct 6.
319 RRP22: a novel neural tumor suppressor for astrocytoma.Med Oncol. 2012 Mar;29(1):332-9. doi: 10.1007/s12032-010-9795-6. Epub 2011 Jan 25.
320 Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis.Oncogene. 2011 Feb 24;30(8):978-89. doi: 10.1038/onc.2010.471. Epub 2010 Oct 18.
321 Differential expression of the RNA-binding motif protein 3 in human astrocytoma.Chin Med J (Engl). 2013;126(10):1948-52.
322 Nuclear phosphorylated Y142 -catenin accumulates in astrocytomas and glioblastomas and regulates cell invasion.Cell Cycle. 2015;14(22):3644-55. doi: 10.1080/15384101.2015.1104443.
323 A novel gene RNF138 expressed in human gliomas and its function in the glioma cell line U251.Anal Cell Pathol (Amst). 2012;35(3):167-78. doi: 10.3233/ACP-2011-0051.
324 Expression Profile of MiR-128 in the Astrocytoma Patients and Cell Lines.Mol Neurobiol. 2016 Sep;53(7):4631-7. doi: 10.1007/s12035-015-9401-1. Epub 2015 Aug 26.
325 Selection of reference genes for gene expression studies in astrocytomas.Anal Biochem. 2011 Jan 1;408(1):163-5. doi: 10.1016/j.ab.2010.09.010. Epub 2010 Sep 16.
326 LPP and RYR2 Gene Polymorphisms Correlate with the Risk and the Prognosis of Astrocytoma.J Mol Neurosci. 2019 Dec;69(4):628-635. doi: 10.1007/s12031-019-01391-z. Epub 2019 Aug 23.
327 S100A13 is a new angiogenic marker in human melanoma.Mod Pathol. 2010 Jun;23(6):804-13. doi: 10.1038/modpathol.2010.54. Epub 2010 Mar 5.
328 Frequent epigenetic inactivation of the chaperone SGNE1/7B2 in human gliomas.Int J Cancer. 2012 Aug 1;131(3):612-22. doi: 10.1002/ijc.26416. Epub 2011 Oct 5.
329 ACTB and SDHA Are Suitable Endogenous Reference Genes for Gene Expression Studies in Human Astrocytomas Using Quantitative RT-PCR.Technol Cancer Res Treat. 2018 Jan 1;17:1533033818802318. doi: 10.1177/1533033818802318.
330 Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton.Oncogene. 2012 Feb 2;31(5):595-610. doi: 10.1038/onc.2011.256. Epub 2011 Jun 27.
331 Expression of Nedd5, a mammalian septin, in human brain tumors.J Neurooncol. 2002 May;57(3):169-77. doi: 10.1023/a:1015721801075.
332 Epidermal growth factor and pro-inflammatory cytokines regulate the expression of components of plasminogen activation system in U373-MG astrocytoma cells.Cytokine. 2001 Dec 7;16(5):187-90. doi: 10.1006/cyto.2001.0957.
333 SWI/SNF gene variants and glioma risk and outcome.Cancer Epidemiol. 2013 Apr;37(2):162-5. doi: 10.1016/j.canep.2012.12.001. Epub 2012 Dec 29.
334 SMN deficiency attenuates migration of U87MG astroglioma cells through the activation of RhoA.Mol Cell Neurosci. 2012 Mar;49(3):282-9. doi: 10.1016/j.mcn.2011.12.003. Epub 2011 Dec 16.
335 Sohlh1 suppresses glioblastoma cell proliferation, migration, and invasion by inhibition of Wnt/-catenin signaling.Mol Carcinog. 2018 Apr;57(4):494-502. doi: 10.1002/mc.22774. Epub 2018 Jan 5.
336 SOX10 Distinguishes Pilocytic and Pilomyxoid Astrocytomas From Ependymomas but Shows No Differences in Expression Level in Ependymomas From Infants Versus Older Children or Among Molecular Subgroups.J Neuropathol Exp Neurol. 2016 Apr;75(4):295-8. doi: 10.1093/jnen/nlw010. Epub 2016 Mar 4.
337 SOX11: a potentially useful marker in surgical pathology: a systematic analysis of SOX11 expression in epithelial and non-epithelial tumours.Histopathology. 2019 Feb;74(3):391-405. doi: 10.1111/his.13757. Epub 2018 Dec 2.
338 Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation.J Neuropathol Exp Neurol. 2011 Sep;70(9):811-26. doi: 10.1097/NEN.0b013e31822c256d.
339 The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility.Exp Cell Res. 2014 Feb 15;321(2):109-22. doi: 10.1016/j.yexcr.2013.11.023. Epub 2013 Dec 10.
340 Expression of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, is enhanced by phorbol-ester stimulation in astroglioma: participation of the PKC signaling pathway.FEBS Lett. 2003 Feb 11;536(1-3):209-14. doi: 10.1016/s0014-5793(03)00015-2.
341 Antiinflammatory actions of gabapentin and pregabalin on the substance Pinduced mitogenactivated protein kinase activation in U373 MG human glioblastoma astrocytoma cells.Mol Med Rep. 2017 Nov;16(5):6109-6115. doi: 10.3892/mmr.2017.7368. Epub 2017 Aug 28.
342 The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites.J Virol. 2000 Feb;74(4):1632-40. doi: 10.1128/jvi.74.4.1632-1640.2000.
343 Mitochondrial DNA depletion and its correlation with TFAM, TFB1M, TFB2M and POLG in human diffusely infiltrating astrocytomas.Mitochondrion. 2011 Jan;11(1):48-53. doi: 10.1016/j.mito.2010.07.001. Epub 2010 Jul 17.
344 Multidimensional analysis of gene expression reveals TGFB1I1-induced EMT contributes to malignant progression of astrocytomas.Oncotarget. 2014 Dec 30;5(24):12593-606. doi: 10.18632/oncotarget.2518.
345 Transforming growth factor-beta-inducible gene-h3 (beta(ig)-h3) promotes cell adhesion of human astrocytoma cells in vitro: implication of alpha6beta4 integrin.Neurosci Lett. 2003 Jan 16;336(2):93-6. doi: 10.1016/s0304-3940(02)01260-0.
346 TIMP-4 and CD63: new prognostic biomarkers in human astrocytomas.Mod Pathol. 2010 Oct;23(10):1418-28. doi: 10.1038/modpathol.2010.136. Epub 2010 Aug 6.
347 Exploring the distinctive biological characteristics of pilocytic and low-grade diffuse astrocytomas using microarray gene expression profiles.J Neuropathol Exp Neurol. 2006 Aug;65(8):794-807. doi: 10.1097/01.jnen.0000228203.12292.a1.
348 Role of Ang1 and its interaction with VEGF-A in astrocytomas.J Neuropathol Exp Neurol. 2004 Sep;63(9):978-89. doi: 10.1093/jnen/63.9.978.
349 Detection of methylation in promoter sequences by melting curve analysis-based semiquantitative real time PCR.BMC Cancer. 2008 Feb 25;8:61. doi: 10.1186/1471-2407-8-61.
350 Higher topoisomerase 2 alpha gene transcript levels predict better prognosis in GBM patients receiving temozolomide chemotherapy: identification of temozolomide as a TOP2A inhibitor.J Neurooncol. 2012 Apr;107(2):289-97. doi: 10.1007/s11060-011-0758-3. Epub 2011 Nov 19.
351 Mutational analysis of TSC1 and TSC2 genes in Tuberous Sclerosis Complex patients from Greece.Sci Rep. 2017 Dec 1;7(1):16697. doi: 10.1038/s41598-017-16988-w.
352 Downregulation of putative tumor suppressor gene TSC-22 in human brain tumors.J Surg Oncol. 2003 Jan;82(1):57-64. doi: 10.1002/jso.10180.
353 The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion.Int J Cancer. 2010 Mar 1;126(5):1155-65. doi: 10.1002/ijc.24849.
354 Epigenetic silencing of death receptor 4 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in gliomas.Clin Cancer Res. 2009 Sep 1;15(17):5457-65. doi: 10.1158/1078-0432.CCR-09-1125. Epub 2009 Aug 25.
355 Aberrant methylation and reduced expression of LHX9 in malignant gliomas of childhood.Neoplasia. 2009 Jul;11(7):700-11. doi: 10.1593/neo.09406.
356 Expression analysis of the autosomal recessive primary microcephaly genes MCPH1 (microcephalin) and MCPH5 (ASPM, abnormal spindle-like, microcephaly associated) in human malignant gliomas.Oncol Rep. 2008 Aug;20(2):301-8.
357 Up-Regulation of microRNA-183 Promotes Cell Proliferation and Invasion in Glioma By Directly Targeting NEFL.Cell Mol Neurobiol. 2016 Nov;36(8):1303-1310. doi: 10.1007/s10571-016-0328-5. Epub 2016 Feb 15.
358 RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs.Brain Pathol. 2009 Apr;19(2):279-92. doi: 10.1111/j.1750-3639.2008.00185.x. Epub 2008 Jun 25.