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Irinotecan FDA Label
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Transcription factor C/EBP- mediates downregulation of dipeptidyl-peptidase III expression by interleukin-6 in human glioblastoma cells.FEBS J. 2014 Mar;281(6):1629-41. doi: 10.1111/febs.12728. Epub 2014 Feb 17.
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Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues.Tumour Biol. 2016 May;37(5):6935-42. doi: 10.1007/s13277-015-4592-7. Epub 2015 Dec 11.
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Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.Oncogene. 2009 Feb 5;28(5):752-61. doi: 10.1038/onc.2008.431. Epub 2008 Dec 1.
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Genome-Wide CRISPR-Cas9 Screening Identifies NF-B/E2F6 Responsible for EGFRvIII-Associated Temozolomide Resistance in Glioblastoma.Adv Sci (Weinh). 2019 Jul 24;6(17):1900782. doi: 10.1002/advs.201900782. eCollection 2019 Sep 4.
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Eukaryotic initiation factor 5B (eIF5B) provides a critical cell survival switch to glioblastoma cells via regulation of apoptosis.Cell Death Dis. 2019 Jan 22;10(2):57. doi: 10.1038/s41419-018-1283-5.
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ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1.Neuro Oncol. 2011 Nov;13(11):1202-12. doi: 10.1093/neuonc/nor119. Epub 2011 Aug 16.
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Attenuation of Tumor Suppressive Function of FBXO16 Ubiquitin Ligase Activates Wnt Signaling In Glioblastoma.Neoplasia. 2019 Jan;21(1):106-116. doi: 10.1016/j.neo.2018.11.005. Epub 2018 Dec 5.
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MiR-9-5p Inhibits Glioblastoma Cells Proliferation Through Directly Targeting FOXP2 (Forkhead Box P2).Front Oncol. 2019 Nov 19;9:1176. doi: 10.3389/fonc.2019.01176. eCollection 2019.
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A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.Nat Commun. 2016 Oct 4;7:12885. doi: 10.1038/ncomms12885.
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Induced expression of GINS complex is an essential step for reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in human glioblastoma.J Cancer Res Clin Oncol. 2019 Feb;145(2):363-371. doi: 10.1007/s00432-018-2797-z. Epub 2018 Nov 21.
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-Elemene inhibits proliferation through crosstalk between glia maturation factor and extracellular signalregulated kinase1/2 and impairs drug resistance to temozolomide in glioblastoma cells.Mol Med Rep. 2014 Aug;10(2):1122-8. doi: 10.3892/mmr.2014.2273. Epub 2014 May 27.
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Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma.Genome Biol. 2015 Jan 27;16(1):16. doi: 10.1186/s13059-015-0583-7.
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Overexpression of HOXC10 promotes glioblastoma cell progression to a poor prognosis via the PI3K/AKT signalling pathway.J Drug Target. 2019 Jan;27(1):60-66. doi: 10.1080/1061186X.2018.1473408. Epub 2018 Aug 6.
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Overexpression of immediate early gene X-1 (IEX-1) enhances gamma-radiation-induced apoptosis of human glioma cell line, U87-MG.Neuropathology. 2009 Feb;29(1):20-4. doi: 10.1111/j.1440-1789.2008.00932.x. Epub 2008 Jun 17.
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The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing.Cell Rep. 2016 May 24;15(8):1634-47. doi: 10.1016/j.celrep.2016.04.086. Epub 2016 May 12.
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MiR-148a inhibits the proliferation and migration of glioblastoma by targeting ITGA9.Hum Cell. 2019 Oct;32(4):548-556. doi: 10.1007/s13577-019-00279-9. Epub 2019 Sep 5.
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NETRIN-4 protects glioblastoma cells FROM temozolomide induced senescence.PLoS One. 2013 Nov 12;8(11):e80363. doi: 10.1371/journal.pone.0080363. eCollection 2013.
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KPNA2 promotes metabolic reprogramming in glioblastomas by regulation of c-myc.J Exp Clin Cancer Res. 2018 Aug 16;37(1):194. doi: 10.1186/s13046-018-0861-9.
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Alteration of major vault protein in human glioblastoma and its relation with EGFR and PTEN status.Neuroscience. 2015 Jun 25;297:243-51. doi: 10.1016/j.neuroscience.2015.04.005. Epub 2015 Apr 11.
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Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells.Oncotarget. 2017 Dec 4;8(68):112942-112958. doi: 10.18632/oncotarget.22896. eCollection 2017 Dec 22.
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MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin.Exp Cell Res. 2014 May 15;324(1):54-64. doi: 10.1016/j.yexcr.2014.03.009. Epub 2014 Mar 21.
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CircFOXO3 promotes glioblastoma progression by acting as a competing endogenous RNA for NFAT5.Neuro Oncol. 2019 Oct 9;21(10):1284-1296. doi: 10.1093/neuonc/noz128.
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Carnosine influences transcription via epigenetic regulation as demonstrated by enhanced histone acetylation of the pyruvate dehydrogenase kinase 4 promoter in glioblastoma cells.Amino Acids. 2019 Jan;51(1):61-71. doi: 10.1007/s00726-018-2619-2. Epub 2018 Jul 20.
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PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1.Mol Cell. 2019 Nov 7;76(3):516-527.e7. doi: 10.1016/j.molcel.2019.08.006. Epub 2019 Sep 3.
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Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype.Cancer Res. 2018 Oct 15;78(20):5901-5916. doi: 10.1158/0008-5472.CAN-18-0320. Epub 2018 Aug 22.
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Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma.Acta Neuropathol Commun. 2016 Sep 1;4(1):96. doi: 10.1186/s40478-016-0372-x.
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Parallel comparison of pre-conditioning and post-conditioning effects in human cancers and keratinocytes upon acute gamma irradiation.Int J Radiat Biol. 2019 Feb;95(2):170-178. doi: 10.1080/09553002.2019.1547850. Epub 2019 Jan 4.
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Retinoic Acid-Induced Protein 14 (RAI14) Promotes mTOR-Mediated Inflammation Under Inflammatory Stress and Chemical Hypoxia in a U87 Glioblastoma Cell Line.Cell Mol Neurobiol. 2019 Mar;39(2):241-254. doi: 10.1007/s10571-018-0644-z. Epub 2018 Dec 15.
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miR-128 and miR-149 enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeletal remodeling in glioblastoma.Oncol Rep. 2014 Sep;32(3):957-64. doi: 10.3892/or.2014.3318. Epub 2014 Jul 10.
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RECQ1 Helicase Silencing Decreases the Tumour Growth Rate of U87 Glioblastoma Cell Xenografts in Zebrafish Embryos.Genes (Basel). 2017 Sep 6;8(9):222. doi: 10.3390/genes8090222.
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Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma.Clin Cancer Res. 2009 Mar 1;15(5):1527-33. doi: 10.1158/1078-0432.CCR-08-2459. Epub 2009 Feb 17.
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Regulatory factor X1 is a new tumor suppressive transcription factor that acts via direct downregulation of CD44 in glioblastoma.Neuro Oncol. 2014 Aug;16(8):1078-85. doi: 10.1093/neuonc/nou010. Epub 2014 Feb 12.
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A multicenter randomized phase III study for newly diagnosed maximally resected glioblastoma comparing carmustine wafer implantation followed by chemoradiotherapy with temozolomide with chemoradiotherapy alone; Japan Clinical Oncology Group Study JCOG1703 (MACS study).Jpn J Clin Oncol. 2019 Dec 27;49(12):1172-1175. doi: 10.1093/jjco/hyz169.
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Down-regulation of ribosomal protein S15A inhibits proliferation of human glioblastoma cells in vivo and in vitro via AKT pathway.Tumour Biol. 2016 Apr;37(4):4979-90. doi: 10.1007/s13277-015-4323-0. Epub 2015 Nov 4.
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Generation of Rybp homozygous knockout murine ES cell line GIBHe001-A-1 by using CRISPR/Cas9 technology.Stem Cell Res. 2019 Dec;41:101638. doi: 10.1016/j.scr.2019.101638. Epub 2019 Oct 26.
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SERPINA3 induced by astroglia/microglia co-culture facilitates glioblastoma stem-like cell invasion.Oncol Lett. 2018 Jan;15(1):285-291. doi: 10.3892/ol.2017.7275. Epub 2017 Oct 26.
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Loss of SH3GL2 promotes the migration and invasion behaviours of glioblastoma cells through activating the STAT3/MMP2 signalling.J Cell Mol Med. 2017 Nov;21(11):2685-2694. doi: 10.1111/jcmm.13184. Epub 2017 May 4.
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Cell density modulates SHC3 expression and survival of human glioblastoma cells through Fak activation.J Neurooncol. 2014 Nov;120(2):245-56. doi: 10.1007/s11060-014-1551-x. Epub 2014 Jul 26.
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Glycan modification of glioblastoma-derived extracellular vesicles enhances receptor-mediated targeting of dendritic cells.J Extracell Vesicles. 2019 Aug 9;8(1):1648995. doi: 10.1080/20013078.2019.1648995. eCollection 2019.
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Preparation and investigation of indirubin-loaded SLN nanoparticles and their anti-cancer effects on human glioblastoma U87MG cells.Cell Biol Int. 2019 Jan;43(1):2-11. doi: 10.1002/cbin.11037.
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Suppression of STIM1 inhibits human glioblastoma cell proliferation and induces G0/G1 phase arrest.J Exp Clin Cancer Res. 2013 Apr 11;32(1):20. doi: 10.1186/1756-9966-32-20.
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SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression.Nat Commun. 2014 Jun 23;5:4234. doi: 10.1038/ncomms5234.
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Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells.Cancer Res. 2008 Jun 15;68(12):4614-22. doi: 10.1158/0008-5472.CAN-07-5291.
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TIPE3 is a regulator of cell apoptosis in glioblastoma.Cancer Lett. 2019 Apr 1;446:1-14. doi: 10.1016/j.canlet.2018.12.019. Epub 2019 Jan 11.
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The CNS penetrating taxane TPI 287 and the AURKA inhibitor alisertib induce synergistic apoptosis in glioblastoma cells.J Neurooncol. 2018 May;137(3):481-492. doi: 10.1007/s11060-018-2755-2. Epub 2018 Feb 2.
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Loss of tumor suppressive microRNA-31 enhances TRADD/NF-B signaling in glioblastoma.Oncotarget. 2015 Jul 10;6(19):17805-16. doi: 10.18632/oncotarget.4596.
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Overexpression of Tripartite Motif-Containing 48 (TRIM48) Inhibits Growth of Human Glioblastoma Cells by Suppressing Extracellular Signal Regulated Kinase 1/2 (ERK1/2) Pathway.Med Sci Monit. 2019 Nov 8;25:8422-8429. doi: 10.12659/MSM.916024.
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