Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTZJYKH)

• DTT Name: Indoleamine 2,3-dioxygenase 1 (IDO1) DTT Info
• Gene Name: IDO1

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[1]

11 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[2]
BMS-986205	DM3MAYQ	Melanoma	2C30	Phase 3	[3]
INCB24360	DMIJGT9	Urothelial carcinoma	2C92.0	Phase 3	[4]
NLG8189	DM0798Z	Melanoma	2C30	Phase 2/3	[3]
DN1406131	DMQFX8R	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
HTI-1090	DMI4TEC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
KHK2455	DMLSUQ8	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
LY3381916	DMONZ1L	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
MK-7162	DMBSXZ1	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
NLG802	DMP9J5V	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
PF-06840003	DMOX6EJ	Glioma	2A00.0	Phase 1	[8]

82 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2,3-diamino-benzo[b]thiophene derivative 1	DMD2KRW	N. A.	N. A.	Patented	[9]
2,3-diamino-benzo[b]thiophene derivative 2	DMDYXKT	N. A.	N. A.	Patented	[9]
2,3-diamino-benzo[b]thiophene derivative 3	DMR7QKL	N. A.	N. A.	Patented	[9]
2,3-diamino-benzo[b]thiophene derivative 4	DMEDFNC	N. A.	N. A.	Patented	[9]
2,3-diamino-benzo[b]thiophene derivative 5	DM05WXD	N. A.	N. A.	Patented	[9]
2,3-diamino-benzo[b]thiophene derivative 6	DMINE6V	N. A.	N. A.	Patented	[9]
2,3-diamino-benzo[b]thiophene derivative 7	DMQVMNJ	N. A.	N. A.	Patented	[9]
2,3-diamino-benzo[b]thiophene derivative 8	DM5O8K0	N. A.	N. A.	Patented	[9]
Acyl piperidine derivative 1	DMX9J1C	N. A.	N. A.	Patented	[10]
Amide derivative 2	DMBKIR0	N. A.	N. A.	Patented	[10]
Aryl 1,2-diamine derivative 1	DMSDRNQ	N. A.	N. A.	Patented	[10]
Aryl sulphoxide imine derivative 1	DMW7HKS	N. A.	N. A.	Patented	[10]
Azetidine derivative 5	DMJ9U0E	N. A.	N. A.	Patented	[10]
Benzimidazole and imadazopyridine carboximidamide compound 1	DM2G83R	N. A.	N. A.	Patented	[10]
Benzimidazole and imadazopyridine carboximidamide compound 2	DMJ2CIY	N. A.	N. A.	Patented	[10]
Biphenyl 1,2-diamine derivative 1	DM1VYZ9	N. A.	N. A.	Patented	[10]
Biphenyl derivative 1	DMG4WQB	N. A.	N. A.	Patented	[10]
Biphenyl derivative 2	DMJ4TZX	N. A.	N. A.	Patented	[10]
Biphenyl derivative 3	DMM3SWV	N. A.	N. A.	Patented	[10]
Carbamide derivative 13	DMCAD64	N. A.	N. A.	Patented	[10]
Cyclic hydroxamate derivative 1	DM0K62M	N. A.	N. A.	Patented	[10]
Cyclohexyl-ethyl-substituted diaza and triaza-tricyclic compound 1	DMI2T1D	N. A.	N. A.	Patented	[10]
Five-membered heteroaromatic compound 1	DMO8UKD	N. A.	N. A.	Patented	[10]
Five-membered heteroaromatic compound 2	DM1QH8Z	N. A.	N. A.	Patented	[10]
Five-membered heteroaromatic compound 3	DMS0P9E	N. A.	N. A.	Patented	[10]
Hexahydro quinoline derivative 1	DM4VNWX	N. A.	N. A.	Patented	[10]
Hydoxyamidine derivative 1	DMFIG8C	N. A.	N. A.	Patented	[10]
Hydroxy amidine derivative 1	DMBHIL2	N. A.	N. A.	Patented	[10]
Hydroxy amidine derivative 2	DM7SUFJ	N. A.	N. A.	Patented	[10]
Imidazo isoindole derivative 1	DM1JXKY	N. A.	N. A.	Patented	[10]
Imidazoleisoindoles derivative 1	DM7UMW2	N. A.	N. A.	Patented	[10]
Imidazoleisoindoles derivative 2	DMRJKIQ	N. A.	N. A.	Patented	[10]
Imidazo[1,5-a]pyridine derivative 1	DMFIP0D	N. A.	N. A.	Patented	[10]
Imidazo[1,5-a]pyridine derivative 2	DMU3PAR	N. A.	N. A.	Patented	[10]
Indazole derivative 2	DMV7AX9	N. A.	N. A.	Patented	[10]
Indazole derivative 3	DMVUWLK	N. A.	N. A.	Patented	[10]
Indazole derivative 4	DMJ2CRO	N. A.	N. A.	Patented	[10]
Monoaryl-1,2-diamine derivative 1	DMCI6YH	N. A.	N. A.	Patented	[10]
Monoaryl-1,2-diamine derivative 2	DMXUNZ1	N. A.	N. A.	Patented	[10]
Monoaryl-1,2-diamine derivative 3	DMAXKPC	N. A.	N. A.	Patented	[10]
Monoaryl-1,2-diamine derivative 4	DMD8AKH	N. A.	N. A.	Patented	[10]
Monofluorine derivative 1	DMJ8YZK	N. A.	N. A.	Patented	[10]
PMID27172114-Compound-30	DMBWLSA	N. A.	N. A.	Patented	[9]
PMID29473428-Compound-10	DM7EW5U	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-11	DM5MXFK	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-14	DMCB0D6	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-15	DM571JP	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-16	DM21QCE	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-17	DMI04GC	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-21	DMZGNWO	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-22	DMCNSZD	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-29	DMBMTUV	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-33	DMZA3FL	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-34	DM7BRPI	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-39	DMKRUPW	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-4	DM9KVOD	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-41	DM4AOIR	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-43	DMQ8EYV	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-47	DMCLJ0M	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-48	DMAYT2E	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-50	DMXUVDH	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-52	DMSXKP6	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-53	DMOASLQ	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-54	DMKIS26	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-58	DMVP7DL	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-59	DMJYUN2	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-6	DMOVPWD	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-60	DMRKWPQ	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-70	DMMV5KI	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-71	DML5G6D	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-72	DMJOBUZ	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-76	DM8PZ46	N. A.	N. A.	Patented	[10]
PMID29473428-Compound-80	DM8VBU2	N. A.	N. A.	Patented	[10]
Pyridine derivative 1	DMSGF8T	N. A.	N. A.	Patented	[10]
Pyridino tricyclic compound 1	DMKQFTY	N. A.	N. A.	Patented	[10]
Pyrrolo[1,2-c]pyrazole derivative 1	DM5RCW8	N. A.	N. A.	Patented	[10]
Sulfamic acid ester derivative 1	DMQ0VK9	N. A.	N. A.	Patented	[10]
Sulfamoylamide derivative 1	DMO7ZRW	N. A.	N. A.	Patented	[10]
Sulfonamide derivative 6	DMD51AV	N. A.	N. A.	Patented	[10]
Sulfonamide derivative 7	DMN5YUK	N. A.	N. A.	Patented	[10]
Sulfonamide derivative 8	DMOXIZC	N. A.	N. A.	Patented	[10]
Thieno[2,3-c]pyridine derivative 1	DMLUPV1	N. A.	N. A.	Patented	[10]

3 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-methyl-L-tryptophan	DMT8SFV	Solid tumour/cancer	2A00-2F9Z	Preclinical	[11]
EPL-1410	DM5K17C	Solid tumour/cancer	2A00-2F9Z	Preclinical	[12]
RG70099	DM7JH0K	Solid tumour/cancer	2A00-2F9Z	Preclinical	[12]

68 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,2-NAPHTHOQUINONE	DMYXELH	Discovery agent	N.A.	Investigative	[2]
1,4-Naphthoquinone	DMTCMH7	Discovery agent	N.A.	Investigative	[2]
1H-indole-4,7-dione	DMNDVMH	Discovery agent	N.A.	Investigative	[13]
2,2-dimethyl-2H-benzo[g]chromene-5,10-dione	DMQYCFI	Discovery agent	N.A.	Investigative	[2]
2,3-dichloro-1,4-naphthoquinone	DMPCGSD	Discovery agent	N.A.	Investigative	[2]
2,3-dihydrobenzo[d]thiazole-2-thiol	DMUW94S	Discovery agent	N.A.	Investigative	[14]
2,4-Dichlorobenzenemethanethiol	DMR5DYK	Discovery agent	N.A.	Investigative	[15]
2-(1H-Imidazol-4-yl)benzene-1,3-diol	DM2PZ1B	Discovery agent	N.A.	Investigative	[16]
2-(1H-Imidazol-4-yl)phenol	DM6MR82	Discovery agent	N.A.	Investigative	[16]
2-Chlorobenzenemethanethiol	DMI89RL	Discovery agent	N.A.	Investigative	[15]
2-hydroxygarveatin E	DM5E1DC	Discovery agent	N.A.	Investigative	[17]
2-HYDROXYGARVIN A	DMK96BL	Discovery agent	N.A.	Investigative	[17]
2-methoxy-1,4-naphthoquinone	DMA5Q4T	Discovery agent	N.A.	Investigative	[2]
3,4-Dichlorobenzenemethanethiol	DMN61Q5	Discovery agent	N.A.	Investigative	[15]
3-(1H-Imidazol-4-yl)benzenethiol	DMERZHK	Discovery agent	N.A.	Investigative	[16]
3-(4H-Imidazol-4-yl)benzenethiol	DMPS1GW	Discovery agent	N.A.	Investigative	[16]
4-(1H-1,2,3-triazol-5-yl)pyridine	DMFWVJI	Discovery agent	N.A.	Investigative	[14]
4-(2-(diethylamino)ethylamino)-1-naphthol	DMRQ8T9	Discovery agent	N.A.	Investigative	[14]
4-(2-Hydroxyethoxy)-1-naphthol	DM17QG8	Discovery agent	N.A.	Investigative	[14]
4-(Benzylamino)-1-naphthol	DMF6S3X	Discovery agent	N.A.	Investigative	[14]
4-(Cyclohexylamino)-1-naphthol	DMUOQN7	Discovery agent	N.A.	Investigative	[14]
4-(ethylamino)naphthalen-1-ol	DM14C9V	Discovery agent	N.A.	Investigative	[14]
4-(Isopropylamino)-1-naphthol	DMJFSTX	Discovery agent	N.A.	Investigative	[14]
4-(methylamino)naphthalen-1-ol	DMF3O10	Discovery agent	N.A.	Investigative	[14]
4-(Pent-3-ylamino)-1-naphthol	DMHIDY6	Discovery agent	N.A.	Investigative	[14]
4-(propylamino)naphthalen-1-ol	DMEAZFJ	Discovery agent	N.A.	Investigative	[14]
4-(tert-butylamino)naphthalen-1-ol	DMU5A2B	Discovery agent	N.A.	Investigative	[14]
4-amino-1,2,5-oxadiazole-3-carboximidamide	DMNXSM2	Discovery agent	N.A.	Investigative	[18]
4-aminonaphthalen-1-ol	DMIG82P	Discovery agent	N.A.	Investigative	[14]
4-Chlorobenzenemethanethiol	DMKTSPM	Discovery agent	N.A.	Investigative	[15]
4-Fluorobenzenemethanethiol	DMS6RHD	Discovery agent	N.A.	Investigative	[15]
4-Methoxybenzenemethanethiol	DMVFLCM	Discovery agent	N.A.	Investigative	[15]
4-methoxynaphthalen-1-amine	DMBS61O	Discovery agent	N.A.	Investigative	[14]
4-Methylbenzenemethanethiol	DM3S2P8	Discovery agent	N.A.	Investigative	[15]
4-Phenylimidazole	DM5UNBW	Discovery agent	N.A.	Investigative	[16]
4-phenylthiazole-2-thiol	DM3B1CE	Discovery agent	N.A.	Investigative	[14]
5-(isopropylamino)quinolin-8-ol	DM45VRX	Discovery agent	N.A.	Investigative	[14]
5-aminoquinolin-8-ol	DMIBHP5	Discovery agent	N.A.	Investigative	[14]
5-phenyl-1H-1,2,3-triazole	DMWF4HX	Discovery agent	N.A.	Investigative	[14]
amg-1	DMUONK5	Discovery agent	N.A.	Investigative	[19]
ANNULIN A	DM0RUQ8	Discovery agent	N.A.	Investigative	[17]
ANNULIN B	DMDQXJ2	Discovery agent	N.A.	Investigative	[17]
ANNULIN C	DMTYQDO	Discovery agent	N.A.	Investigative	[17]
BENZENEMETHANETHIOL	DMK5QYW	Discovery agent	N.A.	Investigative	[15]
BLV-0801	DMGB9PN	Solid tumour/cancer	2A00-2F9Z	Investigative	[20]
Exiguamine A	DMMZH3Q	Discovery agent	N.A.	Investigative	[13]
EXIGUAMINE B	DME1TGM	Discovery agent	N.A.	Investigative	[21]
GARVEATIN A	DM7GX1S	Discovery agent	N.A.	Investigative	[17]
Garveatin C	DMXNQ15	Discovery agent	N.A.	Investigative	[17]
Garveatin E	DMUFZ18	Discovery agent	N.A.	Investigative	[17]
N-[2-(Indol-3-yl)ethyl]-S-benzyl-dithiocarbamate	DMJ8W6F	Discovery agent	N.A.	Investigative	[22]
Naphthalene-1,4-diol	DMOQ43W	Discovery agent	N.A.	Investigative	[14]
PMID24099220C5i	DMWOHAE	Discovery agent	N.A.	Investigative	[11]
S-(2,4-Dichlorobenzyl)isothiourea hydrobromide	DMO1R69	Discovery agent	N.A.	Investigative	[15]
S-(2-Chlorobenzyl)isothiourea hydrochloride	DMN62KP	Discovery agent	N.A.	Investigative	[15]
S-(3,4-Dichlorobenzyl)isothiourea hydrochloride	DMNMCQJ	Discovery agent	N.A.	Investigative	[15]
S-(3-Chlorobenzyl)isothiourea hydrochloride	DMNG6JB	Discovery agent	N.A.	Investigative	[15]
S-(4-Bromobenzyl)isothiourea hydrobromide	DM0XDFG	Discovery agent	N.A.	Investigative	[15]
S-(4-Chlorobenzyl)isothiourea hydrochloride	DMWJE2X	Discovery agent	N.A.	Investigative	[15]
S-(4-Cyanobenzyl)isothiourea hydrobromide	DMYGULD	Discovery agent	N.A.	Investigative	[15]
S-(4-Ethylbenzyl)isothiourea hydrochloride	DMNXDWV	Discovery agent	N.A.	Investigative	[15]
S-(4-Fluorobenzyl)isothiourea hydrochloride	DM10MET	Discovery agent	N.A.	Investigative	[15]
S-(4-Methoxybenzyl)isothiourea hydrochloride	DM4XWAU	Discovery agent	N.A.	Investigative	[15]
S-(4-Methylbenzyl)isothiourea hydrochloride	DMAGLI8	Discovery agent	N.A.	Investigative	[15]
S-(4-Nitrobenzyl)isothiourea hydrochloride	DMYRBO0	Discovery agent	N.A.	Investigative	[15]
S-Benzyl-brassinin	DM2RLXF	Discovery agent	N.A.	Investigative	[22]
Seco-exiguamine	DMY7IVZ	Discovery agent	N.A.	Investigative	[21]
tryptanthrin	DMTRYCI	Discovery agent	N.A.	Investigative	[11]

References

• [1] Interactions between nitric oxide and indoleamine 2,3-dioxygenase. Biochemistry. 2006 Jul 18;45(28):8527-38.
• [2] Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Incyte. Product Development Pipeline.
• [5] ClinicalTrials.gov (NCT03641794) Indoleamine 2,3-Dioxygenase (IDO) Inhibitor in Healthy Volunteers. U.S. National Institutes of Health.
• [6] Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation. J Enzyme Inhib Med Chem. 2019 Dec;34(1):250-263.
• [7] ClinicalTrials.gov (NCT03364049) Study of MK-7162 in Combination With Pembrolizumab (MK-3475) in Adult Participants With Advanced Solid Tumors (MK-7162-002). U.S. National Institutes of Health.
• [8] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [9] Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32.
• [10] A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330.
• [11] Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem. 2013 Nov 14;56(21):8321-31.
• [12] Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401.
• [13] Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A. J Med Chem. 2008 May 8;51(9):2634-7.
• [14] Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89.
• [15] S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9.
• [16] Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. J Med Chem. 2008 Aug 28;51(16):4968-77.
• [17] Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata. J Nat Prod. 2006 Oct;69(10):1496-9.
• [18] Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma mo... J Med Chem. 2009 Dec 10;52(23):7364-7.
• [19] Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors. Biochim Biophys Acta. 2011 Dec;1814(12):1947-54.
• [20] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2829).
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• [22] Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2006 Jan 26;49(2):684-92.