Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM03FHA)

Drug Name
LY293111 Drug Info
Synonyms
Etalocib; LY293111; 161172-51-6; UNII-THY6RIW44R; LY 293111; THY6RIW44R; CHEMBL329123; LY-193111; 2-[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenoxy]benzoic acid; VML295; Etalocib [USAN:INN]; Etalocib (USAN); GTPL2948; SCHEMBL1649516; CTK8E7596; C33H33FO6; VML 295; DTXSID70167073; YFIZRWPXUYFCSN-UHFFFAOYSA-N; MolPort-009-019-411; ZINC3930629; AC1L4328; PDSP2_001221; BDBM50029450; PDSP1_001237; 1758AH; DB12850; RT-013626; D04074; L001468; J-009797; Benzoic acid, 2-(3-(3-((5-ethyl-4'-fluoro-2-hydroxy(1,1'-bipheny
Indication
Disease Entry ICD 11 Status REF
Pancreatic cancer 2C10 Discontinued in Phase 2 [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
177941
ChEBI ID
CHEMBL329123
CAS Number
CAS 161172-51-6
TTD Drug ID
DM03FHA

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Leukotriene B4 receptor 1 (LTB4R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LTB4 DME26RS Human immunodeficiency virus infection 1C62 Phase 2 [4]
Amelubant DMUMCB9 Pulmonary disease 1B10-1F85 Phase 2 [5]
Biomed 101 DMQ9KZW Kidney cancer 2C90.0 Phase 1 [6]
SB-201993 DMIF4VJ Psoriasis vulgaris EA90 Discontinued in Phase 2 [7]
CI-949 DMN4QSW Asthma CA23 Discontinued in Phase 2 [8]
CP-195543 DM1OSUR Rheumatoid arthritis FA20 Discontinued in Phase 2 [9]
LTB 019 DM6G0PN Asthma CA23 Discontinued in Phase 2 [10]
LY-223982 DMWB7DO Asthma CA23 Discontinued in Phase 2 [11]
CP-105696 DM1C4IN Inflammatory bowel disease DD72 Discontinued in Phase 1 [12]
TAK-683 DMRD8HK Prostate cancer 2C82.0 Discontinued in Phase 1 [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Gefitinib DM15F0X Colon adenocarcinoma Approved [15]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [16]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [17]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [18]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [19]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [18]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [20]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [23]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [26]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [27]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [28]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [29]
Gefitinib DM15F0X Colon adenocarcinoma Approved [30]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [33]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [34]
Paclitaxel DMLB81S Breast carcinoma Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [23]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [37]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [26]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [27]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Gefitinib DM15F0X Colon adenocarcinoma Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [45]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [46]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [43]
Ethacrynic acid DM60QMR Edema MG29 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [52]
Sorbitol DMAN0DE Constipation DD91.1 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [55]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Prednisone DM2HG4X Acute asthma CA23 Approved [57]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [58]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Fluoxetine DM3PD2C Bipolar depression Approved [61]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leukotriene B4 receptor 1 (LTB4R) TTN53ZF LT4R1_HUMAN Antagonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [3]
E3 ubiquitin-protein ligase XIAP OT24GP9B XIAP_HUMAN Protein Interaction/Cellular Processes [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Gene/Protein Processing [3]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [3]

References

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3 Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation. Leukemia. 2005 Nov;19(11):1977-84. doi: 10.1038/sj.leu.2403929.
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