Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0WX6I)

• Drug Name: Primidone Drug Info
• Synonyms: Cyral; Desoxyphenobarbital; Desoxyphenobarbitone; Hexadiona; Lepimidin; Lepsiral; Liskantin; Majsolin; Midone; Milepsin; Misodine; Misolyne; Mizodin; Mizolin; Myidone; Mylepsin; Mylepsinum; Mysedon; Mysoline; Neurosyn; Prilepsin; Primacione; Primaclone; Primacone; Primakton; Primidon; Primidona; Primidonum; Primoline; Prysoline; Resimatil; Sertan; Apotex Brand of Primidone; Astra Brand of Primidone; AstraZeneca Brand of Primidone; Desitin Brand of Primidone; Draxis Brand of Primidone; Holsten Brand of Primidone; Pms Primidone; Primidon Holsten; Primidone Methanol Solution; Xcel Brand of Primidone; Zeneca Brand of Primidone; P 7295; Roe 101; Apo-Primidone; Hexamidine (the antispasmodic); Hexamidine(the antispasmodic); Liskantin (TN); Medi-Pets; Mylepsinum (TN); Mysoline (TN); Primidona [INN-Spanish]; Primidone (primaclone); Primidonum [INN-Latin]; Prysoline (TN); Pyrimidone Medi-pets; Resimatil (TN); Sanofi-Synthelabo Brand of Primidone; Sertan (TN); Apo-Primidone (TN); Pyrimidone (Medi-pets); Primidone (JP15/USP/INN); Primidone [USAN:INN:BAN:JAN]; 2-Deoxyphenobarbital; 2-Desoxyphenobarbital; 4,4'-(Hexamethylenedioxy)dibenzamidine; 5-Aethyl-5-phenyl-hexahydropyrimidin-4,6-dion; 5-Aethyl-5-phenyl-hexahydropyrimidin-4,6-dion [German]; 5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione; 5-Ethyldihydro-5-phenyl-4,6(1H,5H)-pyrimidinedione; 5-Ethylhexahydro-4,6-dioxo-5-phenylpyrimidine; 5-Ethylhexahydro-5-phenylpyrimidine-4,6-dione; 5-Phenyl-5-aethylhexahydropyrimidindion-(4,6); 5-Phenyl-5-aethylhexahydropyrimidindion-(4,6) [German]; 5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione; 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione; 5-ethyl-5-phenyldihydropyrimidine-4,6(1H,5H)-dione; 5-ethylhe xahydro-4,6-dioxo-5-phenylpyrimidine

Indication

Disease Entry	ICD 11	Status	REF
Epilepsy	8A60-8A68	Approved	[1]
Epilepsy with generalized tonic-clonic seizures		Approved	[2]
Focal epilepsy		Approved	[2]

• Therapeutic Class: Anticonvulsants
• Cross-matching ID:
  PubChem CID: 4909
  ChEBI ID: CHEMBL8412
  CAS Number: CAS 125-33-7
  TTD Drug ID: DM0WX6I
  INTEDE Drug ID: DR1340
  ACDINA Drug ID: D00555

Molecule-Related Drug Atlas

Drug(s) Targeting GABA(A) receptor alpha-1 (GABRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[3]
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[10]
Methoxyflurane	DML0RAE	Anaesthesia	9A78.6	Approved	[3]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[3]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[11]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[3]
Hexobarbital	DMQ314B	Anaesthesia	9A78.6	Approved	[3]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[12]
Meprobamate	DMHM93Y	Anxiety		Approved	[3]
Zaleplon	DMGFWSM	Insomnia	7A00-7A0Z	Approved	[13]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[14]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[15]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[17]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[19]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[20]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[23]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[14]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[17]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[26]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[28]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[29]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[30]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[31]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[31]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[32]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[30]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[31]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[30]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[33]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[30]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[34]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[6]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[6]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[6]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[6]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[6]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[6]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[40]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[9]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[9]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[45]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]

Drug(s) Affected By Glutathione hydrolase 7 (GGT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[50]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[8]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[51]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[53]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[54]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[55]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor alpha-1 (GABRA1)	TT1MPAY	GBRA1_HUMAN	Antagonist	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9) Main DME	DE5IED8	CP2C9_HUMAN	Substrate	[4]
Mephenytoin 4-hydroxylase (CYP2C19) Main DME	DEGTFWK	CP2CJ_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Gene/Protein Processing	[6]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[7]
Glutathione hydrolase 7 (GGT7)	OTW4IO3I	GGT7_HUMAN	Drug Response	[8]
Protein S100-A8 (S100A8)	OTVMOB3F	S10A8_HUMAN	Gene/Protein Processing	[9]
Protein S100-A9 (S100A9)	OTOARHCS	S10A9_HUMAN	Gene/Protein Processing	[9]

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