Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM14X29)

Drug Name
diarylpropionitril Drug Info
Synonyms
1428-67-7; diarylpropionitrile; 2,3-bis(4-hydroxyphenyl)propionitrile; 2,3-bis(4-hydroxyphenyl)propanenitrile; 2,3-bis(4-hydroxyphenyl)-propionitrile; 2,3-Bis(p-hydroxyphenyl)propionitrile; CHEMBL334773; CHEBI:63949; DPN compound; Benzenepropanenitrile,4-hydroxy-a-(4-hydroxyphenyl)-; SR-01000597601; BRN 3337109; SC-4473; 2,3-Bis(p-hydroxyphenyl)-propionitrile; Propionitrile, 2,3-bis(p-hydroxyphenyl); Propionitrile, 2,3-bis(p-hydroxyphenyl)-; AC1L2T6L; GTPL2825; SCHEMBL1940848; DTXSID0040387; CTK8F9375; MolPort-003-983-761
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
102614
ChEBI ID
CHEBI:63949
CAS Number
CAS 1428-67-7
TTD Drug ID
DM14X29

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Conjugated Estrogens DMLT0E1 Dyspareunia GA12 Approved [10]
Trilostane DMQZ9GF Cushing disease 5A70 Approved [11]
ARZOXIFENE DMOKCVI Breast cancer 2C60-2C65 Approved [12]
Estrogen DMGY0UT Menopause symptom GA30.0 Approved [13]
MF-101 DM8Z0I3 Hepatitis virus infection 1E50-1E51 Phase 3 [14]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [15]
AUS-131 DMUXO3Z Hot flushes GA30 Phase 2 [16]
ERB-041 DMCEPUA Inflammatory bowel disease DD72 Phase 2 [17]
Erteberel DMU1XZD Prostate hyperplasia GA90 Phase 2 [18]
VG-101 DMAN21O Menopause symptom GA30.0 Phase 1/2 [19]
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Drug(s) Affected By Delta(24)-sterol reductase (DHCR24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [20]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
Fluoxetine DM3PD2C Bipolar depression Approved [23]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [24]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [25]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [29]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [30]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [31]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [32]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [33]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Ethacrynic acid DM60QMR Edema MG29 Approved [36]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [37]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [38]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [39]
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Drug(s) Affected By Apolipoprotein D (APOD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [43]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [44]
Paclitaxel DMLB81S Breast carcinoma Approved [45]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [46]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [40]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [48]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [49]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [50]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [51]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [52]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Verapamil DMA7PEW Angina pectoris BA40 Approved [55]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [56]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [57]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [58]
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Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Ethanol DMDRQZU Chronic pain MG30 Approved [66]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [67]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [68]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [76]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [77]
Testosterone DM7HUNW Hot flushes GA30 Approved [78]
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Drug(s) Affected By Occludin (OCLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Testosterone DM7HUNW Hot flushes GA30 Approved [78]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [83]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ethanol DMDRQZU Chronic pain MG30 Approved [84]
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Drug(s) Affected By Nuclear respiratory factor 1 (NRF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [88]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [89]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [90]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Arsenic DMTL2Y1 N. A. N. A. Approved [92]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [93]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [94]
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Drug(s) Affected By Programmed cell death protein 4 (PDCD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [95]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [99]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [100]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [95]
Testosterone DM7HUNW Hot flushes GA30 Approved [78]
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Drug(s) Affected By Junctional adhesion molecule A (F11R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Selenium DM25CGV N. A. N. A. Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [29]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [102]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [103]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor beta (ESR2) TTOM3J0 ESR2_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apolipoprotein D (APOD) OTT77XW8 APOD_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [5]
Delta(24)-sterol reductase (DHCR24) OTP301JW DHC24_HUMAN Gene/Protein Processing [6]
Junctional adhesion molecule A (F11R) OTGHPAV6 JAM1_HUMAN Gene/Protein Processing [7]
Nuclear respiratory factor 1 (NRF1) OTOXWNV8 NRF1_HUMAN Gene/Protein Processing [8]
Occludin (OCLN) OTSUTVWL OCLN_HUMAN Gene/Protein Processing [7]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Gene/Protein Processing [4]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Gene/Protein Processing [4]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Gene/Protein Processing [9]

References

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31 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
32 Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
33 Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
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35 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
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37 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
38 The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
39 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
40 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
41 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
42 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
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58 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
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60 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
61 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
62 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
63 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
64 Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
65 Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model. Acta Neurol Scand Suppl. 2009;(189):14-21.
66 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
67 Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure. Toxicol Lett. 2019 Mar 1;302:7-17.
68 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
69 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
70 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
71 Astaxanthin protects mesenchymal stem cells from oxidative stress by direct scavenging of free radicals and modulation of cell signaling. Chem Biol Interact. 2021 Jan 5;333:109324. doi: 10.1016/j.cbi.2020.109324. Epub 2020 Nov 17.
72 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
73 Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. Br J Nutr. 2012 Mar;107(6):781-90. doi: 10.1017/S0007114511003631. Epub 2011 Aug 1.
74 Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
75 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
76 Arsenic trioxide inhibits the proliferation of myeloma cell line through notch signaling pathway. Cancer Cell Int. 2013 Mar 13;13(1):25. doi: 10.1186/1475-2867-13-25.
77 Mechanism of thalidomide to enhance cytotoxicity of temozolomide in U251-MG glioma cells in vitro. Chin Med J (Engl). 2009 Jun 5;122(11):1260-6.
78 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
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