General Information of Drug (ID: DM4QO9G)

Drug Name
Mononitrophenol Drug Info
Synonyms
Paranitrofenol; Paranitrofenol [Dutch]; Paranitrofenolo; Paranitrofenolo [Italian]; Paranitrophenol; Paranitrophenol [French,German]; Phenol, 4-nitro-; 4-Nitrophenol; Niphen; Phenol, p-nitro-; RCRA waste no. U170; RCRA waste number U170; UN1663; p-Hydroxynitrobenzene; p-Nitrofenol; p-Nitrofenol [Czech]; p-nitrophenol; para-nitrophenol; 1-Hydroxy-4-nitrobenzene; 100-02-7; 4-Hydroxynitrobenzene; 4-Nitrofenol; 4-Nitrofenol [Dutch]; 4-nitro-phenol; Caswell No. 603; NCI-C55992; NSC 1317; PNP; UNII-Y92ZL45L4R
Cross-matching ID
PubChem CID
980
ChEBI ID
CHEBI:16836
CAS Number
CAS 100-02-7
TTD Drug ID
DM4QO9G
INTEDE Drug ID
DR1969

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Drug(s) Metabolized By Sulfotransferase 1A2 (SULT1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [15]
Rotigotine DMP7X6Q N. A. N. A. Approved [16]
Drug(s) Metabolized By Sulfotransferase 1B1 (SULT1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [17]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [15]
Rotigotine DMP7X6Q N. A. N. A. Approved [16]
ABT-751 DMNG35S Solid tumour/cancer 2A00-2F9Z Phase 2 [18]
Aminophenol DMEMCQ9 N. A. N. A. Investigative [1]
Drug(s) Metabolized By Cytochrome P450 102A1 (cyp102)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [6]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [19]
Propranolol DM79NTF Angina pectoris BA40 Approved [20]
Dextromethorphan DMUDJZM Allergic rhinitis CA08.0 Approved [6]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [5]
Chlorzoxazone DMCYVDT Acute pain MG31 Approved [5]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [6]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [6]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [19]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [19]
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Drug(s) Metabolized By Nitroreductase (NTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [3]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [3]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [21]
Nitrobenzoate DM6FVHC N. A. N. A. Investigative [3] , [4]
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [22]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [23]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [25]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [26]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [30]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [28]
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Drug(s) Affected By Sulfotransferase 2A1 (SULT2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [34]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [35]
Leflunomide DMR8ONJ Arthritis FA20 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
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Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [40]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [41]
Minoxidil DMA2Z4F Alopecia ED70 Approved [42]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [15]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
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Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tegafur DM31ZQM Solid tumour/cancer 2A00-2F9Z Approved [47]
Methoxsalen DME8FZ9 Cutaneous T-cell lymphoma 2B01 Approved [48]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [40]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [51]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [53]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [54]
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Drug(s) Affected By Sulfotransferase 4A1 (SULT4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic DMTL2Y1 N. A. N. A. Approved [55]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [56]
Estrone DM5T6US Acne vulgaris ED80 Approved [57]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [57]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [58]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [59]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [60]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [61]
L-thyroxine DM83HWL N. A. N. A. Investigative [57]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [62]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [64]
Selenium DM25CGV N. A. N. A. Approved [65]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [67]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [68]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [73]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
Panobinostat DM58WKG Chronic graft versus host disease Approved [77]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [78]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [79]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [71]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [8]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [81]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [82]
Capsaicin DMGMF6V Back pain ME84.Z Approved [83]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [84]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [85]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [84]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [8]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [86]
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Drug(s) Affected By Sulfotransferase 1E1 (SULT1E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [43]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Estrone DM5T6US Acne vulgaris ED80 Approved [87]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [43]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [87]
Ethanol DMDRQZU Chronic pain MG30 Approved [88]
Folic Acid DMEMBJC Colorectal carcinoma Approved [89]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [90]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [91]
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Drug(s) Affected By Sulfotransferase 1A3 (SULT1A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ethanol DMDRQZU Chronic pain MG30 Approved [88]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [94]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [95]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [96]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [15]
Epinephrine DM3KJBC Acute asthma CA23 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [42]
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Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fomepizole DM6VOWQ Athylene glycol or methanol poisoning NE61 Approved [97]
Ademetionine DMYQDBO Hepatic fibrosis DB93.0 Approved [98]
Theophylline DMRJFN9 Bronchitis CA20 Approved [86]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [99]
Ethanol DMDRQZU Chronic pain MG30 Approved [100]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [40]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [86]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [8]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [102]
Methotrexate DM2TEOL Anterior urethra cancer Approved [103]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [104]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [105]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [106]
Paclitaxel DMLB81S Breast carcinoma Approved [107]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [108]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [110]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [111]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [112]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [113]
Methotrexate DM2TEOL Anterior urethra cancer Approved [103]
Leflunomide DMR8ONJ Arthritis FA20 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [114]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [115]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [116]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [117]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [118]
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Drug(s) Affected By GTPase HRas (HRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [119]
Selenium DM25CGV N. A. N. A. Approved [65]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [121]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [123]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [124]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [125]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [126]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [127]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Sulfotransferase 1B1 (SULT1B1) DED5UR3 ST1B1_HUMAN Substrate [1]
Sulfotransferase 1A2 (SULT1A2) DERUZL7 ST1A2_HUMAN Substrate [2]
Nitroreductase (NTR) DE0K82S A0A5K1UB29_SALTM Substrate [3] , [4]
Cytochrome P450 102A1 (cyp102) DE4OGUF CPXB_BACMB Substrate [5] , [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Biotransformations [7]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Biotransformations [8]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Biotransformations [8]
Cytochrome P450 2E1 (CYP2E1) OTHQ17JG CP2E1_HUMAN Biotransformations [9]
Glutathione S-transferase A2 (GSTA2) OTW7UB1H GSTA2_HUMAN Regulation of Drug Effects [10]
GTPase HRas (HRAS) OTWQN0DP RASH_HUMAN Biotransformations [7]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [11]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Biotransformations [12]
Serum paraoxonase/arylesterase 1 (PON1) OTD0Z2XO PON1_HUMAN Biotransformations [13]
Sulfotransferase 1A1 (SULT1A1) OT0K7JIE ST1A1_HUMAN Regulation of Drug Effects [14]

References

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10 Functional polymorphism of human glutathione transferase A2. Pharmacogenetics. 2004 Feb;14(2):111-6. doi: 10.1097/00008571-200402000-00005.
11 A novel approach for a toxicity prediction model of environmental pollutants by using a quantitative structure-activity relationship method based on toxicogenomics. ISRN Toxicol. 2011 Jul 2;2011:515724. doi: 10.5402/2011/515724. Print 2011.
12 Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: potential sources of metabolic drug interactions. Toxicology. 2010 Apr 11;270(2-3):59-65. doi: 10.1016/j.tox.2010.01.009. Epub 2010 Jan 25.
13 Is paraoxonase 192 gene polymorphism a risk factor for membranoproliferative glomerulonephritis in children?. Cell Biochem Funct. 2007 Mar-Apr;25(2):159-65. doi: 10.1002/cbf.1288.
14 Sulfation of environmental estrogen-like chemicals by human cytosolic sulfotransferases. Biochem Biophys Res Commun. 2000 Jan 7;267(1):80-4. doi: 10.1006/bbrc.1999.1935.
15 Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4.
16 Identification of the human SULT enzymes involved in the metabolism of rotigotine. J Clin Pharmacol. 2016 Jun;56(6):754-60.
17 Molecular cloning, expression, and functional characterization of novel mouse sulfotransferases. Biochem Biophys Res Commun. 1998 Jun 29;247(3):681-6.
18 Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751. Pharmacogenet Genomics. 2013 Jul;23(7):374-81.
19 Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753.
20 acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
21 CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro. Mutagenesis. 2013 Nov;28(6):645-51.
22 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
23 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
24 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
25 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
26 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
27 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
28 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
29 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
30 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
31 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
32 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
33 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
34 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
35 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
36 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
37 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
38 Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
39 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
40 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
41 Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
42 Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms. Drug Metab Dispos. 2001 Mar;29(3):274-81.
43 Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
44 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
45 Methotrexate induction of human sulfotransferases in Hep G2 and Caco-2 cells. J Appl Toxicol. 2005 Sep-Oct;25(5):354-60.
46 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
47 Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans. Drug Metab Dispos. 2005 Sep;33(9):1361-6. doi: 10.1124/dmd.105.004796. Epub 2005 Jun 24.
48 Mimicking gene defects to treat drug dependence. Ann N Y Acad Sci. 2000;909:233-46. doi: 10.1111/j.1749-6632.2000.tb06685.x.
49 Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur. Jpn J Cancer Res. 2001 May;92(5):524-8. doi: 10.1111/j.1349-7006.2001.tb01125.x.
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