Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5FSJA)

Drug Name
Glimepiride Drug Info
Synonyms
Amarel; Amaryl; Endial; Glimepirid; Glimepirida; Glimepiridum; Glimepride; Glimer; Glymepirid; Roname; Solosa; Glimepirida [Spanish]; Glimepiridum [Latin]; Sandoz glimepiride; HOE 490; Amaryl (TN); Hoe-490; Novo-glimepiride; PMS-glimepiride; Ratio-glimepiride; Amaryl, Glista OD, Glimepiride; Glimepiride [USAN:BAN:INN]; Glimepiride (JAN/USP/INN); 1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea; 1-{[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]sulfonyl}-3-(trans-4-methylcyclohexyl)urea; 3-ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide; 3-ethyl-4-methyl-n-(4-(n-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro; 4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide; 64598P
Indication
Disease Entry ICD 11 Status REF
Diabetic complication 5A2Y Approved [1]
Therapeutic Class
Hypoglycemic Agents
Cross-matching ID
PubChem CID
3476
ChEBI ID
CHEMBL5383
CAS Number
CAS 261361-60-8
TTD Drug ID
DM5FSJA
VARIDT Drug ID
DR00158
INTEDE Drug ID
DR0777
ACDINA Drug ID
D00302

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting ATP-binding cassette transporter C9 (ABCC9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [11]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [12]
Nicorandil DMIYJFV Angina pectoris BA40 Approved [13]
BTS-67582 DM54K2P Diabetic complication 5A2Y Discontinued in Phase 2 [14]
KRN-2391 DMZ1SEW Angina pectoris BA40 Discontinued in Phase 2 [15]
CCX915 DMHMST3 Multiple sclerosis 8A40 Discontinued in Phase 1 [16]
BMS-191095 DMKFXTD Angina pectoris BA40 Discontinued in Phase 1 [17]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Targeting ATP-binding cassette transporter C8 (ABCC8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [18]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [11]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [12]
Acetohexamide DMR6N7H Diabetic complication 5A2Y Approved [19]
Gliclazide DMN6QO5 Diabetic complication 5A2Y Approved [20]
NN-414 DMRJEXM Type-1 diabetes 5A10 Phase 1 [21]
HBR-985 DMKDBFL Discovery agent N.A. Investigative [22]
NS-11757 DM98VMZ Atrial fibrillation BC81.3 Investigative [23]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Transported By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [24]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [3]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [3]
Taurocholic Acid DM2LZ8F Type-2 diabetes 5A11 Phase 1/2 [25]
Sodium taurocholate DM3GO0J Type-2 diabetes 5A11 Phase 1/2 [24]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [3]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [3]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [35]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [7]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [3]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [36]
Gefitinib DM15F0X Colon adenocarcinoma Approved [7]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [37]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [7]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [38]
⏷ Show the Full List of 15 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [27]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [28]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [29]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [30]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [29]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [32]
Estrone DM5T6US Acne vulgaris ED80 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [40]
Diazepam DM08E9O Alcohol withdrawal Approved [41]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [42]
Desogestrel DM27U4Y Contraception QA21 Approved [42]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [40]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [40]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [46]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [40]
Diazepam DM08E9O Alcohol withdrawal Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [40]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [40]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [48]
Ethacrynic acid DM60QMR Edema MG29 Approved [47]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [40]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [10]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [10]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [50]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [52]
Etidronic acid DM1XHYJ Bone Paget disease Approved [10]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [10]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [10]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [53]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calpain-1 catalytic subunit (CAPN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Selenium DM25CGV N. A. N. A. Approved [56]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calpain-2 catalytic subunit (CAPN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [70]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [8]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain G (HLA-G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [56]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [9]
Methotrexate DM2TEOL Anterior urethra cancer Approved [71]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [9]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [9]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [73]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [9]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [9]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [9]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calpain-10 (CAPN10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [76]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [76]
Arsenic DMTL2Y1 N. A. N. A. Approved [77]
Urethane DM7NSI0 N. A. N. A. Phase 4 [78]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [79]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 8 (ABCC8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [80]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [81]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [82]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [79]
L-leucine DMQHN7I Discovery agent N.A. Investigative
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Drug(s) Affected By ATP-binding cassette sub-family C member 9 (ABCC9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [84]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [85]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [86]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [87]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [88]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [89]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [90]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ATP-binding cassette transporter C8 (ABCC8) TTP835K ABCC8_HUMAN Blocker [2]
ATP-binding cassette transporter C9 (ABCC9) TTEF5MJ ABCC9_HUMAN Blocker [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Bile salt export pump (ABCB11) DTJ0EW4 ABCBB_HUMAN Substrate [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C9 (CYP2C9) Main DME DE5IED8 CP2C9_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Gene/Protein Processing [5]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Gene/Protein Processing [5]
ATP-binding cassette sub-family C member 8 (ABCC8) OTCWQ54I ABCC8_HUMAN Drug Response [6]
ATP-binding cassette sub-family C member 9 (ABCC9) OTGAXLQN ABCC9_HUMAN Drug Response [6]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [7]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Gene/Protein Processing [8]
Calpain-10 (CAPN10) OTS9LJW4 CAN10_HUMAN Gene/Protein Processing [8]
Calpain-2 catalytic subunit (CAPN2) OTIAPE5J CAN2_HUMAN Gene/Protein Processing [8]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Gene/Protein Processing [9]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [10]

References

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