Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6XFHS)

• Drug Name: SPI-1005 Drug Info
• Synonyms: Ebselen [INN]; Ebselene; Ebselene [French]; Ebseleno; Ebseleno [Spanish]; Ebselenum; Ebselenum [Latin]; Harmokisane; PZ 51; PZ-51; PZ51; RP 60931; SPI-1005; SPI-3005; 2-Phenyl-1,2-benzisoselenazol-3(2H)-one; 2-Phenyl-1,2-benzisoselenazolin-3-one; 2-phenyl-1,2-benzoisoselenazol-3(2H)-one; 2-phenyl-1,2-benzoselenazol-3-one; DR 3305; DR-3305; E 3520

Indication

Disease Entry	ICD 11	Status	REF
Reperfusion injury	ND56.Z	Approved	[1]
Meniere disease	AB31.0	Phase 2b	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[3]

• Therapeutic Class: Fibrinolytic Agents
• Cross-matching ID:
  PubChem CID: 3194
  ChEBI ID: CHEMBL51085
  CAS Number: CAS 60940-34-3
  TTD Drug ID: DM6XFHS

Molecule-Related Drug Atlas

Drug(s) Targeting Serum albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gadobenate Dimeglumine	DM4VAOG	Schizophrenia	6A20	Approved	[8]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[9]
Oxyphenbutazone	DMPZS7U	Arthritis	FA20	Approved	[10]
Iodipamide	DMXIQYS	Gallbladder disease	DC11.3	Approved	[11]
Gadofosveset	DM5V9U1	Imaging	QA0B	Approved	[12]
Albumin Human	DM5JTPU	Hypoalbuminemia	5C53.2	Approved	[13]
Bismuth	DMTKU46	Diarrhea	ME05.1	Approved	[14]
EVANS BLUE	DM5GT1M	Abdominal aortic aneurysm	BD50.4	Approved	[15]
Activated recombinant FVII-albumin fusion protein	DMKY9GI	Hemophilia	3B10.0	Phase 2/3	[16]
Vobarilizumab	DM9KNJT	Rheumatoid arthritis	FA20	Phase 2	[17]

Drug(s) Targeting COVID-19 papain-like proteinase (PL-PRO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[3]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[18]
PX-12	DMLVHAJ	Pancreatic cancer	2C10	Phase 2	[3]
Tideglusib	DME4LA1	Alzheimer disease	8A20	Phase 2	[3]
Hexylcarbamoyl fluorouracil	DMYNPK8	Solid tumour/cancer	2A00-2F9Z	Withdrawn from market	[3]
PMID26868298-compound-N3	DMQFUCD	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[3]
GRL0617	DMX9AGF	Coronavirus infection	1D92	Preclinical	[19]
Isoarnebin 4	DM0B7NO	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[3]
PMID32321856-compound-11a	DMN39V6	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[20]
PMID32321856-compound-11b	DM31QEY	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[20]

Drug(s) Affected By Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[29]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[29]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[6]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[31]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[6]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[6]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[6]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[31]

Drug(s) Affected By Phosphoethanolamine/phosphocholine phosphatase (PHOSPHO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[34]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[7]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[36]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[37]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[38]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serum albumin (ALB)	TTFNGC9	ALBU_HUMAN	Binder	[4]
COVID-19 papain-like proteinase (PL-PRO)	TTNHMO8	R1AB_SARS2 (819-2763)	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)	OTU0FC24	COX41_HUMAN	Gene/Protein Processing	[5]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Gene/Protein Processing	[6]
Phosphoethanolamine/phosphocholine phosphatase (PHOSPHO1)	OT43A0JA	PHOP1_HUMAN	Gene/Protein Processing	[7]

References

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