Details of the Drug-Related molecule(s) Interaction Atlas

TRYPTAMINE Drug Info

tryptamine; 61-54-1; 2-(1H-Indol-3-yl)ethanamine; 3-(2-aminoethyl)indole; 1H-Indole-3-ethanamine; 2-(3-Indolyl)ethylamine; Indol-3-ethylamine; Indole, 3-(2-aminoethyl)-; 2-(Indol-3-yl)ethylamine; 2-(1H-Indol-3-Yl)Ethan-1-Amine; 3-Indoleethylamine; Tryptamin; 2-(1H-indol-3-yl)ethylamine; 2-Indol-3-ylethylamine; 2-(1H-INDOL-3-YL)-ETHYLAMINE; UNII-422ZU9N5TV; (Amino-2 ethyl)-3 indole; (Amino-2 ethyl)-3 indole [French]; Tryptamine, 98%; BRN 0125513; EINECS 200-510-5; CHEMBL6640; 422ZU9N5TV; CHEBI:16765; APJYDQYYACXCRM-UHFFFAOYSA-N

Cross-matching ID

PubChem CID

1150

ChEBI ID

CHEBI:16765

CAS Number

CAS 61-54-1

TTD Drug ID

DMAFPHB

General Information of Drug (ID: DMAFPHB)

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting 5-HT 2A receptor (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[8]
ZOTEPINE	DMF3VXA	Anxiety disorder	6B00-6B0Z	Approved	[9]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[10]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[11]
Lurasidone hydrochloride	DMCVPXO	Schizophrenia	6A20	Approved	[12]
Aniracetam	DMOIFW0	Cerebrovascular ischaemia	8B1Z	Approved	[13]
lumateperone tosylate	DMQ8HOJ	Schizophrenia	6A20	Approved	[14]
Sarpogrelate	DMGLP6S	Diabetic complication	5A2Y	Approved	[15]
Pimavanserin	DMR7IVC	Parkinson disease	8A00.0	Approved	[16]
Zicronapine	DMP8ESD	Schizophrenia	6A20	Phase 3	[17]
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Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[18]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[19]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[20]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[21]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[22]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[23]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[24]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[25]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[26]
Budipine	DMODHQI	Migraine	8A80	Approved	[27]
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Drug(s) Targeting Monoamine oxidase type A (MAO-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Moclobemide	DMNZWL7	Depression	6A70-6A7Z	Approved	[28]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[29]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[30]
Isocarboxazid	DMAF1NB	Depression	6A70-6A7Z	Approved	[31]
Psoralen	DMIZJ8M	N. A.	N. A.	Phase 3	[32]
CHF-3381	DMQ2O8V	Neuropathic pain	8E43.0	Phase 2	[33]
Ladostigil	DMJSY3Q	Alzheimer disease	8A20	Phase 2	[34]
CX157	DMS2WB5	Mood disorder	6A60-6E23	Phase 2	[35]
PIPERINE	DMYEAB1	Vitiligo	ED63.0	Phase 1/2	[36]
Desoxypeganine	DMTR7EH	Alcohol dependence	6C40.2	Phase 1	[37]
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Drug(s) Affected By 5-hydroxytryptamine receptor 2A (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[38]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[39]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[40]
Haloperidol	DM96SE0	Delirium		Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[42]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[45]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[46]
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Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[47]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[48]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[52]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[55]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[56]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[57]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[57]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[58]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[60]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[57]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[57]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[61]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[62]
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Drug(s) Affected By Trace amine-associated receptor 1 (TAAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Octopamine	DMLQVTJ	Thrombosis	DB61-GB90	Discontinued in Phase 2a	[7]
PHENETHYLAMINE	DMX0G4F	Discovery agent	N.A.	Investigative	[7]
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Drug(s) Affected By Amine oxidase A (MAOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[67]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
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Drug(s) Affected By Amine oxidase B (MAOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
BENZYL BENZOATE	DMDPYI5	Infestations of lice and scabies	1G00.Z	Approved	[76]
Linezolid	DMGFPU2	Bacteremia	1A73	Approved	[77]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[1]
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[2]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Drug Response	[3]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Biotransformations	[4]
Amine oxidase B (MAOB)	OTTDFM1O	AOFB_HUMAN	Biotransformations	[4]
Cytochrome P450 2A6 (CYP2A6)	OT52TWG3	CP2A6_HUMAN	Gene/Protein Processing	[5]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Gene/Protein Processing	[6]
Trace amine-associated receptor 1 (TAAR1)	OTUY8CGM	TAAR1_HUMAN	Gene/Protein Processing	[7]

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