Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME2A8X)

Drug Name

5-methoxypsoralen Drug Info

Synonyms

5-MOP

Indication

Disease Entry	ICD 11	Status	REF
Psoriasis vulgaris	EA90	Phase 3	[1]

Cross-matching ID

PubChem CID: 2355
ChEBI ID: CHEMBL24171
CAS Number: CAS 484-20-8
TTD Drug ID: DME2A8X
INTEDE Drug ID: DR1910

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[6]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[7]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[8]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[10]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[13]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[7]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[14]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[15]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[16]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[21]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[22]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[23]
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Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[15]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[24]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[10]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Metronidazole	DMTIVEN	Abscess		Approved	[27]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[28]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
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Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[30]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[31]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[21]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[34]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[35]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[36]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[37]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[38]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[42]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[21]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[24]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[43]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[45]
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Drug(s) Metabolized By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[21]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[35]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[36]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[47]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[48]
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[49]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[50]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[49]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[51]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[52]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[53]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[54]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[55]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[56]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[57]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[58]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[59]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[57]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[60]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[63]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[66]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[67]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[68]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[69]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[74]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
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Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[81]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[84]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[85]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[86]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[88]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[89]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[90]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[91]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[92]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[93]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[94]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[97]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[98]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[2]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Substrate	[3]
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Substrate	[3]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Substrate	[3]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[3]
Cytochrome P450 1B1 (CYP1B1)	DE9QHP6	CP1B1_HUMAN	Substrate	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[4]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[5]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[5]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Gene/Protein Processing	[5]

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