Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG3F94)

Drug Name
Mestranol Drug Info
Synonyms
Devocin; Menophase; Mestranolo; Mestranolum; Norquen; Ovastol; Component of Norinyl; Component of Norquen; Component of Ovulen; Ethynylestradiol methyl ether; Mestranol [Steroidal oestrogens]; Mestranolo [DCIT]; EE3ME; Ethinyl Estradiol 3 Methyl Ether; SC 4725; Component of Ortho-Novum; Delta-MVE; EE(sub3)ME; EthinylEstradiol 3-Methyl Ether; Ethinylestradiol 3-methyl ether; Ethinyloestradiol 3-methyl ether; Ethynylestradiol 3-methyl ether; Ethynyloestradiol 3-methyl ether; Inostral (steroid); Mestranolum [INN-Latin]; Mestranol (JP15/USP/INN); Mestranol [USAN:INN:BAN:JAN]; Alpha.-19-Norpregna-1,3,5(10)-trien-20-yn-17-ol, 3-meth; (17beta)-17-ethynyl-3-(methyloxy)estra-1,3,5(10)-trien-17-ol; 17-Ethynyl-3-methoxy-1,3,5(10)-oestratien-17-beta-ol; 17-Ethynyl-3-methoxyestra-1,3,5(10)-trien-17-ol; 17-Ethynylestradiol 3-methyl ether; 17-Ethynyloestradiol 3-methyl ether; 17-alpha-Ethinyl estradiol 3-methyl ether; 17-alpha-Ethinyl oestradiol 3-methyl ether; 17-alpha-Ethynyl-3-methoxy-1,3,5(10)-estratrien-17-beta-ol; 17-alpha-Ethynyloestradiol methyl ether; 17-ethynyl-3-methoxyestra-1(10),2,4-trien-17beta-ol; 17-ethynyl-3-methoxyoestra-1(10),2,4-trien-17beta-ol; 17alpha-Ethinyl estradiol 3-methyl ether; 17alpha-Ethinyl oestradiol 3-methyl ether; 17alpha-Ethinylestradiol 3-methyl ether; 17alpha-Ethynylestradiol 3-methyl ether; 17alpha-Ethynylestradiol methyl ether; 17alpha-Ethynyloestradiol 3-methyl ether; 17beta-Estradiol, 17-ethynyl-, 3-(methyl ether); 3-Methoxy-17-alpha-19-norpregna-1,3,5(10)-trien-20-yn-17-ol; 3-Methoxy-17-alpha-ethinylestradiol; 3-Methoxy-17-alpha-ethinyloestradiol; 3-Methoxy-17-alpha-ethynyl-1,3,5(10)-estratrien-17-beta-ol; 3-Methoxy-17-alpha-ethynyl-1,3,5(10)-oestratrien-17-beta-ol; 3-Methoxy-17-alpha-ethynylestradiol; 3-Methoxy-17-alpha-ethynyloestradiol; 3-Methoxy-17-ethynyloestradiol-17-beta; 3-Methoxy-17alpha-ethinylestradiol; 3-Methoxy-17alpha-ethinyloestradiol; 3-Methoxy-17alpha-ethynyl-1,3,5(10)-estratrien-17beta-ol; 3-Methoxy-17alpha-ethynyl-1,3,5(10)-oestratrien-17beta-ol; 3-Methoxy-17alpha-ethynylestradiol; 3-Methoxy-17alpha-ethynyloestradiol; 3-Methoxy-19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yn-17-ol; 3-Methoxy-19-nor-17alpha-pregna-1,3,5(10)-trien-20-yn-17-ol; 3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17beta-ol; 3-Methoxyethynylestradiol; 3-Methoxyethynyloestradiol; 3-Methylethynylestradiol; 3-Methylethynyloestradiol; 3-O-Methylethynylestradiol
Indication
Disease Entry ICD 11 Status REF
Contraception QA21 Approved [1]
Menorrhagia GA20.50 Approved [2]
Endometriosis GA10 Investigative [2]
Therapeutic Class
Estrogens
Cross-matching ID
PubChem CID
6291
ChEBI ID
CHEMBL6784
CAS Number
CAS 72-33-3
TTD Drug ID
DMG3F94
INTEDE Drug ID
DR1034

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor (ESR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [8]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [9]
Estrone DM5T6US Acne vulgaris ED80 Approved [9]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [10]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [10]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [10]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [11]
Raloxifene DMDKF3M Osteoporosis FB83.0 Approved [12]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [13]
Toremifene DMQYUWG Breast cancer 2C60-2C65 Approved [14]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [15]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [16]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [17]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [18]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [19]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [20]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [21]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [22]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [16]
Verapamil DMA7PEW Angina pectoris BA40 Approved [5]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [23]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [25]
Verapamil DMA7PEW Angina pectoris BA40 Approved [26]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [27]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [28]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [24]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [29]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [30]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [31]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [25]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [34]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [25]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [36]
Estrone DM5T6US Acne vulgaris ED80 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
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Drug(s) Affected By E3 ubiquitin-protein ligase SIAH2 (SIAH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [41]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [43]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
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Drug(s) Affected By Carbonic anhydrase 12 (CA12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [46]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [50]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
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Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [53]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [56]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [58]
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Drug(s) Affected By monooxygenase MICAL2 (MICAL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [62]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [7]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
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Drug(s) Affected By Serine protease 23 (PRSS23)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [66]
Testosterone DM7HUNW Hot flushes GA30 Approved [67]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [68]
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Drug(s) Affected By Supervillin (SVIL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [72]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [73]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [7]
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Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [74]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [74]
Testosterone DM7HUNW Hot flushes GA30 Approved [77]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [78]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [43]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [43]
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Drug(s) Affected By Monoacylglycerol lipase ABHD2 (ABHD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Selenium DM25CGV N. A. N. A. Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Testosterone enanthate DMB6871 N. A. N. A. Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [7]
Bortezomib DMNO38U Leukemia Approved [81]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
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Drug(s) Affected By Transcriptional activator Myb (MYB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [83]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [84]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [86]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [87]
Testosterone DM7HUNW Hot flushes GA30 Approved [67]
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Drug(s) Affected By Myb-related protein A (MYBL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [90]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
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Drug(s) Affected By CD44 antigen (CD44)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Selenium DM25CGV N. A. N. A. Approved [93]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [94]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [97]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [98]
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Drug(s) Affected By Ephrin-A1 (EFNA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [100]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [66]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [78]
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Drug(s) Affected By Single-stranded DNA-binding protein 2 (SSBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Testosterone DM7HUNW Hot flushes GA30 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [7]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [102]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [103]
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Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Selenium DM25CGV N. A. N. A. Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [106]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [107]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [108]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
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Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [109]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [110]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [114]
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Drug(s) Affected By Early growth response protein 3 (EGR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [107]
Estrone DM5T6US Acne vulgaris ED80 Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [116]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [66]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [117]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
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Drug(s) Affected By Four and a half LIM domains protein 2 (FHL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [118]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [66]
Testosterone DM7HUNW Hot flushes GA30 Approved [67]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [67]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
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Drug(s) Affected By Cyclin-G2 (CCNG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Fluoxetine DM3PD2C Bipolar depression Approved [119]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [100]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [117]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [43]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
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Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [107]
Estrone DM5T6US Acne vulgaris ED80 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [120]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [73]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [121]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [121]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [121]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
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Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [122]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [78]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [7]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [123]
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Drug(s) Affected By Transcription factor AP-2 gamma (TFAP2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [124]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [62]
Paclitaxel DMLB81S Breast carcinoma Approved [125]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [7]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [126]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Sgk3 (SGK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [66]
Testosterone enanthate DMB6871 N. A. N. A. Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [7]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inactive rhomboid protein 1 (RHBDF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [127]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [128]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [7]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Arsenic DMTL2Y1 N. A. N. A. Approved [129]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calmin (CLMN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Testosterone DM7HUNW Hot flushes GA30 Approved [67]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [127]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [128]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA endonuclease RBBP8 (RBBP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Testosterone DM7HUNW Hot flushes GA30 Approved [67]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [120]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [130]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [126]
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Drug(s) Affected By Noelin (OLFM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [131]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [132]
Arsenic DMTL2Y1 N. A. N. A. Approved [133]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [134]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [135]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [136]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pleckstrin homology domain-containing family F member 2 (PLEKHF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [7]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [137]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [138]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rap guanine nucleotide exchange factor-like 1 (RAPGEFL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [66]
Testosterone DM7HUNW Hot flushes GA30 Approved [77]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [7]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [139]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [140]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [141]
Urethane DM7NSI0 N. A. N. A. Phase 4 [142]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA 3'-terminal phosphate cyclase-like protein (RCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Estrone DM5T6US Acne vulgaris ED80 Approved [7]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [143]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [144]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [62]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein GREB1 (GREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [145]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [146]
Testosterone DM7HUNW Hot flushes GA30 Approved [77]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Nandrolone DMFWKG1 Osteoporosis FB83.0 Approved [147]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [148]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Agonist [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [5]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Calmin (CLMN) OT7U5J3T CLMN_HUMAN Gene/Protein Processing [7]
Carbonic anhydrase 12 (CA12) OT6WNFU8 CAH12_HUMAN Gene/Protein Processing [7]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Gene/Protein Processing [7]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Gene/Protein Processing [7]
DNA endonuclease RBBP8 (RBBP8) OTRHJ3GI CTIP_HUMAN Gene/Protein Processing [7]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Gene/Protein Processing [7]
E3 ubiquitin-protein ligase SIAH2 (SIAH2) OTKED2XN SIAH2_HUMAN Gene/Protein Processing [7]
Early growth response protein 3 (EGR3) OTGPJIRA EGR3_HUMAN Gene/Protein Processing [7]
Ephrin-A1 (EFNA1) OTU2NUA2 EFNA1_HUMAN Gene/Protein Processing [7]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Gene/Protein Processing [7]

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131 Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
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