Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGC5DB)

Drug Name
Ciprofibrate Drug Info
Synonyms
Ciprofibrato; Ciprofibratum; Ciprol; Hiperlipen; Hyperlipen; Lipanor; Modalim; Oroxadin; Sanofi Synthelabo brand of ciprofibrate; Sanofi Winthrop brand of ciprofibrate; C 0330; WIN 35833; Ciprofibrato [INN-Spanish]; Ciprofibratum [INN-Latin]; Win 35,833; Win-35833; Ciprofibrate (USAN/INN); Ciprofibrate [USAN:BAN:INN]; 2-(4-(2,2-Dichlorocyclopropyl)phenoxy)2-methylpropanoic acid; 2-(p-(2,2-Dichlorocyclopropyl)phenoxy)-2-methylpropionic acid; 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid; 2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid; 2-{4-[2,2-dichlorocyclopropyl]phenoxy}-2-methylpropanoic acid; 2-{[4-(2,2-dichlorocyclopropyl)phenyl]oxy}-2-methylpropanoic acid
Indication
Disease Entry ICD 11 Status REF
Hyperlipoproteinemia 5C80 Approved [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
2763
ChEBI ID
CHEBI:50867
CAS Number
CAS 52214-84-3
TTD Drug ID
DMGC5DB
VARIDT Drug ID
DR01188
INTEDE Drug ID
DR0330

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Peroxisome proliferator-activated receptor alpha (PPARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lobeglitazone DMHY3IP Type-2 diabetes 5A11 Approved [11]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [2]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [12]
Pemafibrate DMD1VZL Hyperlipidemia 5C80.Z Approved [13]
MURAGLITAZAR DMG3NFZ N. A. N. A. Phase 3 [14]
Ragaglitazar DMFSHEM Type-1 diabetes 5A10 Phase 3 [15]
CS-038 DM67P0F Type-2 diabetes 5A11 Phase 3 [16]
TESAGLITAZAR DMGRBN5 Type-1 diabetes 5A10 Phase 3 [17]
GFT-505 DM7ZOAE Non-alcoholic steatohepatitis DB92.1 Phase 3 [18]
ZYH-1 DMMBJYC Lipid metabolism disorder 5C52.Z Phase 3 [19]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [21]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [22]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [26]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [27]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [21]
Verapamil DMA7PEW Angina pectoris BA40 Approved [28]
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Drug(s) Affected By Lipoprotein lipase (LPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [29]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [35]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [36]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [37]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [36]
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Drug(s) Affected By Sulfotransferase 2A1 (SULT2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [41]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [42]
Leflunomide DMR8ONJ Arthritis FA20 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
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Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [49]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [50]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [51]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [52]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [55]
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Drug(s) Affected By Apolipoprotein A-I (APOA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [58]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [59]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [60]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [61]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [63]
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Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [64]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [58]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [67]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [68]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [70]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
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Drug(s) Affected By Transcriptional activator Myb (MYB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Estrone DM5T6US Acne vulgaris ED80 Approved [72]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [76]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [77]
Testosterone DM7HUNW Hot flushes GA30 Approved [70]
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Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Selenium DM25CGV N. A. N. A. Approved [79]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [84]
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Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
Testosterone DM7HUNW Hot flushes GA30 Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [87]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [88]
Capsaicin DMGMF6V Back pain ME84.Z Approved [89]
Sodium Acetate Anhydrous DMH21E0 Hyponatraemia 5C72 Approved [90]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [91]
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Drug(s) Affected By Perilipin-2 (PLIN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [94]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [95]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [96]
Leflunomide DMR8ONJ Arthritis FA20 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [97]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [87]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Peroxisome proliferator-activated receptor alpha (PPARA) TTJ584C PPARA_HUMAN Agonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Gene/Protein Processing [4]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Gene/Protein Processing [5]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Gene/Protein Processing [6]
Lipoprotein lipase (LPL) OTTW0267 LIPL_HUMAN Gene/Protein Processing [7]
Monocyte differentiation antigen CD14 (CD14) OT83GJ47 CD14_HUMAN Gene/Protein Processing [6]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Gene/Protein Processing [8]
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) OTM0A0DY ACOX1_HUMAN Gene/Protein Processing [9]
Sulfotransferase 2A1 (SULT2A1) OT0ISKQ4 ST2A1_HUMAN Gene/Protein Processing [10]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Gene/Protein Processing [6]

References

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31 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
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38 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
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68 Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
69 Histamine downregulates CD14 expression via H2 receptors on human monocytes. Clin Immunol. 2003 Sep;108(3):274-81. doi: 10.1016/s1521-6616(03)00140-2.
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75 Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
76 Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
77 Thalidomide alters c-MYB and PIM-1 signaling in K-562 cells. Pharmacol Res. 2006 Aug;54(2):91-6. doi: 10.1016/j.phrs.2006.02.010. Epub 2006 Mar 8.
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