Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGQFYB)

• Drug Name: Mecamylamine Drug Info
• Synonyms: Mecamilamina; Mecamine; Mecamylaminum; Mekamine; Mevasine; Revertina; Versamine; Inversine hydrochloride; Mecamilamina [DCIT]; Mecamilamina [Italian]; Mevasin hydrochloride; Inversine (TN); Mecamylamine [INN:BAN]; Mecamylaminum [INN-Latin]; N-Methyl-2-isocamphanamine; N,2,3,3-Tetramethyl-2-norbornamine; N,2,3,3-Tetramethyl-2-norcamphanamine; N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine; N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine; 2-Methylamino-2,3,3-trimethylnorbornane; 2-Methylaminoisocamphane; 3-Methylaminoisocamphane; 3-Methylaminoisokamfan; 3-Methylaminoisokamfan [Czech]; 3-beta-Methylamino-2,2,3-trimethylbicyclo(2.2.1)heptane

Indication

Disease Entry	ICD 11	Status	REF
Essential hypertension	BA00	Approved	[1]

• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 4032
  ChEBI ID: CHEMBL267936
  CAS Number: CAS 60-40-2
  TTD Drug ID: DMGQFYB
  ACDINA Drug ID: D00386

Molecule-Related Drug Atlas

Drug(s) Targeting Nicotinic acetylcholine receptor (nAChR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[5]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[6]
Pancuronium	DMB0VY8	Anaesthesia	9A78.6	Approved	[7]
Atracurium	DM42HXN	Anaesthesia	9A78.6	Approved	[7]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[8]
Dexefaroxan	DMTY4KN	Parkinson disease	8A00.0	Phase 2	[9]
BMS-954561	DM7XV4R	Diabetic neuropathy	8C0Z	Phase 2	[10]
ASM-024	DM35S2I	Asthma	CA23	Phase 2	[11]
NIC-002	DMKLJMI	Nicotine dependence	6C4A.2	Phase 2	[12]
TRIDMAC	DMWU41P	Mood disorder	6A60-6E23	Phase 2	[13]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase alpha (PTPRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[14]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[19]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[20]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[3]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[21]

Drug(s) Affected By Fasciculation and elongation protein zeta-1 (FEZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[26]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[29]

Drug(s) Affected By Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[36]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[37]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[39]
Haloperidol	DM96SE0	Delirium		Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[40]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[40]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[41]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[42]

Drug(s) Affected By Golgin subfamily A member 4 (GOLGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[26]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[4]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[45]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nicotinic acetylcholine receptor (nAChR)	TTJSZTB	NOUNIPROTAC	Antagonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Fasciculation and elongation protein zeta-1 (FEZ1)	OTWCXPRE	FEZ1_HUMAN	Gene/Protein Processing	[3]
Golgin subfamily A member 4 (GOLGA4)	OTCMEHNJ	GOGA4_HUMAN	Gene/Protein Processing	[4]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)	OTT5JX1F	LITAF_HUMAN	Gene/Protein Processing	[3]
Receptor-type tyrosine-protein phosphatase alpha (PTPRA)	OTZA82J1	PTPRA_HUMAN	Gene/Protein Processing	[3]
Stress-induced-phosphoprotein 1 (STIP1)	OT7TXLOX	STIP1_HUMAN	Gene/Protein Processing	[4]
Ubiquitin-protein ligase E3A	OTIA27P3	UBE3A_HUMAN	Gene/Protein Processing	[3]
Zinc finger RNA-binding protein	OTYDAOT8	ZFR_HUMAN	Gene/Protein Processing	[3]

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