Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI9FBP)

Drug Name

Imipenem Drug Info

Synonyms

Imipemide; Tienamycin; Imipenem anhydrous; Imipenem (INN); N-Formimidoylthienamycin; Primaxin (TN); Imipenem, N-Formimidoyl thienamycin; [5R-[5.alpha.,6.alpha.(R*)]]-6-(1-Hydroxyethyl)-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate; (5R,6S)-3-(2-Formimidoylamino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (5R,6S)-6-((R)-1-Hydroxyethyl)-3-(2-(iminomethylamino)ethylthio)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carbonsaeure; (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Bacteremia	1A73	Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Endometritis		Approved	[1]
Peritonitis		Approved	[1]
Pelvic inflammatory disease	GA05	Investigative	[1]

Therapeutic Class

Antibiotics

Cross-matching ID

PubChem CID: 104838
ChEBI ID: CHEBI:471744
CAS Number: CAS 64221-86-9
TTD Drug ID: DMI9FBP
INTEDE Drug ID: DR2447

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bacterial Penicillin binding protein 2 (Bact mrdA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cefepime	DMHVWIK	Bacterial infection	1A00-1C4Z	Approved	[22]
Amdinocillin	DMIG6FY	Bacterial infection	1A00-1C4Z	Approved	[23]
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Drug(s) Metabolized By Beta-lactamase (blaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[5]
Ertapenem	DM4S3O8	Bacterial infection	1A00-1C4Z	Approved	[5]
Doripenem	DM9UCJK	Cholecystitis		Approved	[5]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[24]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[25]
Avibactam	DM1AEH4	N. A.	N. A.	Approved	[26] , [27]
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[25] , [26]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[25]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[28]
Piperacillin	DMTBKF3	Acute gonococcal cervicitis		Approved	[28]
Tazobactam	DM3XNUI	Appendicitis	DB10	Approved	[28]
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[28]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[29]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[29]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[10]
Carbapenem	DMXZU73	N. A.	N. A.	Phase 4	[30]
Ceftazidine	DMPZTRC	N. A.	N. A.	Phase 4	[29]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[13]
Ertapenem	DM4S3O8	Bacterial infection	1A00-1C4Z	Approved	[31]
Cefpodoxime	DMJUNY5	Acute gonococcal cervicitis		Approved	[32]
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Drug(s) Metabolized By AmpC beta-lactamase (ampC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[11]
Cefalotin	DMVYSLE	Bacteremia	1A73	Approved	[11]
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Drug(s) Metabolized By Carbapenemase (cphA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[8]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[21]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[21]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[33]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[35]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[21]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[21]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[21]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[36]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[37]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Penicillin binding protein 2 (Bact mrdA)	TTHWB7G	MRDA_ECOLI	Binder	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-lactamase (blaB)	DE7IH52	AMPC_CITFR	Substrate	[4]
Beta-lactamase (blaB)	DEC3G7M	A0A1S7IV31_ENTAS	Substrate	[5] , [6]
Beta-lactamase (blaB)	DEYIEO5	AMPC_SERMA	Substrate	[4] , [7]
Carbapenemase (cphA)	DEB90AL	BLAB_AERHY	Substrate	[8] , [9]
Beta-lactamase (blaB)	DEBKS91	A0A1B1FBM9_ACIBA	Substrate	[10]
AmpC beta-lactamase (ampC)	DERI7LO	A0A0H3KQ39_BURM1	Substrate	[11]
Carbapenemase (cphA)	DETRKSD	A0A3G1JAD7_ALCXX	Substrate	[12]
Beta-lactamase (blaB)	DECWSA9	AMPC_MORMO	Substrate	[13]
Beta-lactamase (blaB)	DEUHIQS	A0A1S7IV31_ENTAS	Substrate	[14] , [15]
Beta-lactamase (blaB)	DECB2MX	A0A1M5PLB6_9FLAO	Substrate	[16]
Beta-lactamase (blaB)	DEEQ3RW	K0GG60_CITBR	Substrate	[17]
Beta-lactamase (blaB)	DEQ0K5J	A0A223JZR3_9ENTR	Substrate	[17]
Beta-lactamase (blaB)	DE7MYGB	A0A291NY45_PROSP	Substrate	[4]
Beta-lactamase (blaB)	DEL6894	A0A2S8DM15_SHIBO	Substrate	[17]
Beta-lactamase (blaB)	DE8KH4C	A0A3B7D7C4_9VIBR	Substrate	[18]
Carbapenemase (cphA)	DEQ4LIN	Q8L1M8_9ENTR	Substrate	[19]
Carbapenemase (cphA)	DE9QNXV	A0A366EJX1_9ENTR	Substrate	[20]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Gene/Protein Processing	[21]

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References

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37	Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.