Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJCOKV)

Drug Name
PALMATINE Drug Info
Synonyms
Palmatine; 3486-67-7; Berbericinine; O,O-Dimethyldemethyleneberberine; Palmatin; Burasaine; UNII-G50C034217; 7,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxyberbinium; Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-; BRN 1555498; GNF-PF-4086; CHEBI:16096; 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium; 2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium; 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo(a,g)quinolizinium; Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-; G50C034217
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
19009
ChEBI ID
CHEMBL206106
CAS Number
CAS 3486-67-7
TTD Drug ID
DMJCOKV

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Albendazole monooxygenase (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [6]
PMX-53 DMZUAJ4 Atopic dermatitis EA80 Phase 2 [7]
BMS-536924 DMXJB4N Discovery agent N.A. Investigative [8]
Heme DMGC287 Discovery agent N.A. Investigative [9]
ML-3163 DM3S5UC Discovery agent N.A. Investigative [10]
6-(3-Hydroxy-phenyl)-naphthalen-2-ol DMH8WA2 Discovery agent N.A. Investigative [11]
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole DMZVBPG Discovery agent N.A. Investigative [12]
ML-3375 DMXJY6W Discovery agent N.A. Investigative [10]
ML-3403 DMTQWI8 Discovery agent N.A. Investigative [10]
4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol DM7ERYJ Discovery agent N.A. Investigative [13]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [14]
Gefitinib DM15F0X Colon adenocarcinoma Approved [15]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [16]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [17]
Etretinate DM2CZFA Keratosis ED56 Approved [18]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [19]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [20]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [23]
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Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [24]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [26]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Gefitinib DM15F0X Colon adenocarcinoma Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Selenium DM25CGV N. A. N. A. Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
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Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [34]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [38]
Testosterone enanthate DMB6871 N. A. N. A. Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [3]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [41]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [42]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [43]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [46]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [47]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [48]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [51]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [49]
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Drug(s) Affected By C-C motif chemokine 3 (CCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [58]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [3]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [3]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [52]
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Drug(s) Affected By C-C motif chemokine 4 (CCL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [58]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [60]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [3]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [3]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [63]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [52]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Gefitinib DM15F0X Colon adenocarcinoma Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [67]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [68]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [69]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [70]
Quercetin DM3NC4M Obesity 5B81 Approved [71]
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Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [77]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [58]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [78]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Selenium DM25CGV N. A. N. A. Approved [30]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [81]
Etretinate DM2CZFA Keratosis ED56 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [83]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [84]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [85]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
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Drug(s) Affected By Cell division control protein 42 homolog (CDC42)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [90]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [91]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [95]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [96]
Bortezomib DMNO38U Leukemia Approved [97]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Albendazole monooxygenase (CYP3A4) TTXV4FI CP3A4_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Protein Interaction/Cellular Processes [2]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [3]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Gene/Protein Processing [3]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Gene/Protein Processing [3]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Gene/Protein Processing [3]
Cell division control protein 42 homolog (CDC42) OT5QBC5M CDC42_HUMAN Protein Interaction/Cellular Processes [4]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Gene/Protein Processing [5]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Gene/Protein Processing [3]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [3]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Protein Interaction/Cellular Processes [4]

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27 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
28 Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res. 2005 Oct 15;11(20):7480-9. doi: 10.1158/1078-0432.CCR-05-0328.
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61 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
62 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
63 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
64 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
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68 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
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71 Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFB and AhR and EGFR-ERK pathway. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):138-49.
72 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
73 A copper-hydrogen peroxide redox system induces dityrosine cross-links and chemokine oligomerisation. Cytokine. 2011 Dec;56(3):669-75. doi: 10.1016/j.cyto.2011.08.025. Epub 2011 Oct 1.
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