Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML36ZE)

• Drug Name: LY-292223 Drug Info
• Synonyms: 2-(4-Morpholinyl)-4H-1-benzopyran-4-one; 2-morpholinochromone; LY-292223; CHEMBL367315; 2-morpholino-4H-chromen-4-one; 130735-56-7; U67154; AC1L2YUR; U-67154; SCHEMBL3361567; 2-morpholin-4-ylchromen-4-one; DTXSID30156701; 2-Morpholin-4-yl-chromen-4-one; QNFWERYZJLBANZ-UHFFFAOYSA-N; BDBM50098118; 2-(4-Morpholinyl)-4H-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 131255
  CAS Number: CAS 130735-56-7
  TTD Drug ID: DML36ZE

Molecule-Related Drug Atlas

Drug(s) Targeting Endothelin-converting enzyme 1 (ECE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SCH-54470	DMEWLZ7	N. A.	N. A.	Terminated	[4]
CGS 35066	DMCHT27	Discovery agent	N.A.	Investigative	[5]
PO3 2-Nle-Trp-O-3K	DMW1XY4	Discovery agent	N.A.	Investigative	[6]
PMID19899765C22	DMBTV20	Discovery agent	N.A.	Investigative	[4]
PO3 2-Leu-Trp-O-3K	DM3O78D	Discovery agent	N.A.	Investigative	[6]
5-(2-hydroxyethyl)nonane-1,9-diol	DMHBD1T	Discovery agent	N.A.	Investigative	[7]
PO3 2-Ile-Trp-O-3K	DMQMDSG	Discovery agent	N.A.	Investigative	[6]
PD159790	DM6RVTO	Discovery agent	N.A.	Investigative	[8]
PO3 2-Leu-Nal-O-3K	DMY43FU	Discovery agent	N.A.	Investigative	[6]

Drug(s) Targeting PI3-kinase delta (PIK3CD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[9]
Idelalisib	DM602WT	Chronic lymphocytic leukaemia	2A82.0	Approved	[10]
Umbralisib	DMYRBO1	Follicular lymphoma	2A80	Approved	[11]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[12]
Leniolisib	DMWAD93	Stomach cancer	2B72	Approved	[13]
Buparlisib	DM1WEHC	Breast cancer	2C60-2C65	Phase 3	[14]
INCB50465	DMZJP2T	Diffuse large B-cell lymphoma	2A81	Phase 2	[15]
ME-401	DMK0UOY	Follicular lymphoma	2A80	Phase 2	[15]
RP6530	DMYILGK	Chronic lymphocytic leukaemia	2A82.0	Phase 2	[15]
Parsaclisib	DMYBIFS	Follicular lymphoma	2A80	Phase 2	[16]

Drug(s) Targeting DNA-dependent protein kinase catalytic (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
M3814	DMK2L38	Locally advanced rectal cancer	2B92	Phase 1/2	[15]
AZD7648	DMD9Y5T	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[17]
M9831	DM59TI2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[15]
PP121	DMU8KTO	Discovery agent	N.A.	Investigative	[18]
Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate	DM3FH02	Discovery agent	N.A.	Investigative	[19]
PIK-75	DM9BQTX	Discovery agent	N.A.	Investigative	[20]
KU-0060648	DMQWS6U	Discovery agent	N.A.	Investigative	[21]
ALPHA-NAPHTHOFLAVONE	DMELOIQ	Discovery agent	N.A.	Investigative	[22]
2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one	DM79ZOV	Discovery agent	N.A.	Investigative	[22]
2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one	DMAHZR9	Discovery agent	N.A.	Investigative	[3]

Drug(s) Targeting Angiotensin-converting enzyme (ACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[23]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[24]
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[25]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[26]
Moexipril	DM26E4B	Hypertension	BA00-BA04	Approved	[27]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[28]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[29]
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[30]
Fosinopril	DM9NJ52	Chronic heart failure	BD1Z	Approved	[31]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[32]

Drug(s) Targeting PI3K p110 beta messenger RNA (PIK3CB mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate	DM3FH02	Discovery agent	N.A.	Investigative	[1]
3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol	DM54MDH	Discovery agent	N.A.	Investigative	[33]
ISIS 32014	DMF5SK8	Discovery agent	N.A.	Investigative	[34]
ISIS 32024	DMPKGIU	Discovery agent	N.A.	Investigative	[34]
ISIS 32035	DM47B2O	Discovery agent	N.A.	Investigative	[34]
ISIS 32000	DM0O9WM	Discovery agent	N.A.	Investigative	[34]
ISIS 32021	DMISB5V	Discovery agent	N.A.	Investigative	[34]
ISIS 32003	DM7EVQX	Discovery agent	N.A.	Investigative	[34]
ISIS 32028	DMATWDO	Discovery agent	N.A.	Investigative	[34]
ISIS 32039	DMY1R0Q	Discovery agent	N.A.	Investigative	[34]

Drug(s) Targeting PI3-kinase gamma (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[35]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[12]
Buparlisib	DM1WEHC	Breast cancer	2C60-2C65	Phase 3	[14]
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[15]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[36]
GDC-0032	DMT4QHD	Breast cancer	2C60-2C65	Phase 3	[15]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[37]
SAR245409	DMQM7IL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[38]
XL147	DMML7BE	Solid tumour/cancer	2A00-2F9Z	Phase 2	[38]
SF1126	DML10K3	Head and neck cancer	2D42	Phase 2	[39]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin-converting enzyme (ACE)	TTL69WB	ACE_HUMAN	Inhibitor	[2]
DNA-dependent protein kinase catalytic (PRKDC)	TTK3PY9	PRKDC_HUMAN	Inhibitor	[3]
Endothelin-converting enzyme 1 (ECE1)	TTQ9RYT	ECE1_HUMAN	Inhibitor	[2]
PI3-kinase delta (PIK3CD)	TTGBPJE	PK3CD_HUMAN	Inhibitor	[1]
PI3-kinase gamma (PIK3CG)	TTHBTOP	PK3CG_HUMAN	Inhibitor	[1]
PI3K p110 beta messenger RNA (PIK3CB mRNA)	TT9H4P3	PK3CB_HUMAN	Inhibitor	[1]

References

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• [23] Determination of bezafibrate, methotrexate, cyclophosphamide, orlistat and enalapril in waste and surface waters using on-line solid-phase extracti... J Environ Monit. 2009 Apr;11(4):830-8.
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