Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOU93V)

Drug Name
Cyclic Guanosine Monophosphate Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
135398570
ChEBI ID
CHEMBL395336
CAS Number
CAS 7665-99-8
TTD Drug ID
DMOU93V
VARIDT Drug ID
DR01380

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Investigative Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting cAMP-dependent protein kinase A type I (PRKAR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RO-316233 DMAGLPW Discovery agent N.A. Investigative [10]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [2]
AdoC(Dpr)2AlaArg6 DM2TWSZ Discovery agent N.A. Investigative [11]
AdcAhxArg4NH(CH2)6NH2 DMSYMRJ Discovery agent N.A. Investigative [12]
AdcAhxArg4Lys-PEGOMe DMQ2C8X Discovery agent N.A. Investigative [12]
AdoC(GABA)Arg6 DMMWNPT Discovery agent N.A. Investigative [11]
AdcAhxArg4Lys(biotin)-PEG-OMe DMZYJHV Discovery agent N.A. Investigative [12]
AdoC(Aun)Arg6 DMDLHAB Discovery agent N.A. Investigative [11]
AdoCGlyArg6 DMVQJP0 Discovery agent N.A. Investigative [11]
AdoC(Aoc)Arg6 DMRSCO2 Discovery agent N.A. Investigative [11]
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Drug(s) Targeting Phosphodiesterase 2A (PDE2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tofisopam DMTGNWU Hyperuricaemia 5C55.Y Phase 2 [13]
CP-461 DMEYMTX Inflammatory bowel disease DD72 Phase 2 [14]
ND7001 DMUBTC6 Mood disorder 6A60-6E23 Phase 1 [15]
Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 1 DMC8935 N. A. N. A. Patented [16]
Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 2 DM4CSBD N. A. N. A. Patented [16]
Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 2 DMS3ROL N. A. N. A. Patented [16]
Triazolo-pyridine derivative 5 DM1R205 N. A. N. A. Patented [16]
PMID27321640-Compound-58 DM0NYK3 N. A. N. A. Patented [16]
Triazolo-pyridine derivative 4 DM5ZQKS N. A. N. A. Patented [16]
Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 3 DMZ61T8 N. A. N. A. Patented [16]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [17]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [18]
Gefitinib DM15F0X Colon adenocarcinoma Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [23]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [24]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [21]
Ethacrynic acid DM60QMR Edema MG29 Approved [25]
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Drug(s) Affected By High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Testosterone DM7HUNW Hot flushes GA30 Approved [27]
Leflunomide DMR8ONJ Arthritis FA20 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [32]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [33]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [34]
Urethane DM7NSI0 N. A. N. A. Phase 4 [35]
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Drug(s) Affected By cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [36]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [36]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [36]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [41]
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Drug(s) Affected By Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [43]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [44]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [45]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [41]
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Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [48]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [50]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
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Drug(s) Affected By Guanylate cyclase soluble subunit alpha-1 (GUCY1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Panobinostat DM58WKG Chronic graft versus host disease Approved [56]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Folic Acid DMEMBJC Colorectal carcinoma Approved [59]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [61]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
cAMP-dependent protein kinase A type I (PRKAR1A) TTNAHEX KAP0_HUMAN Inhibitor [2]
Phosphodiesterase 2A (PDE2A) TTJGW1Z PDE2A_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Regulation of Drug Effects [3]
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A) OT74EK7Z PDE10_HUMAN Biotransformations [4]
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A) OT9X261C PDE11_HUMAN Biotransformations [5]
Guanylate cyclase soluble subunit alpha-1 (GUCY1A1) OTPTCBUN GCYA1_HUMAN Regulation of Drug Effects [6]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A) OT4U3QHF PDE9A_HUMAN Biotransformations [7]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Gene/Protein Processing [8]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Regulation of Drug Effects [9]

References

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