Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPWB8G)

Drug Name

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Drug Info

Synonyms

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP; 28289-54-5; CCRIS 2186; 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine; HSDB 6942; PYRIDINE, 1,2,3,6-TETRAHYDRO-1-METHYL-4-PHENYL-; 1-METHYL-4-PHENYL-PIPERIDINE-3-EN; UNII-9P21XSP91P; N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NSC 139654; EINECS 248-939-7; 1-Methyl-4-phenyl-1,2,3,6-tetrahydroxpyridine; BRN 0133712; CHEMBL24172; 9P21XSP91P; 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine; CHEBI:17963; 1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine; PLRACCBDVIHHLZ-UHFFFAOYSA-N

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1388
ChEBI ID: CHEMBL24172
CAS Number: CAS 28289-54-5
TTD Drug ID: DMPWB8G

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[5]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[6]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[7]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[8]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[9]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[10]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[11]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[12]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[13]
Budipine	DMODHQI	Migraine	8A80	Approved	[14]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[16]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[18]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[19]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[20]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[21]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[22]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[25]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[16]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[26]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[27]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[30]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[18]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[19]
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Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[36]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Bortezomib	DMNO38U	Leukemia		Approved	[38]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Gene/Protein Processing	[2]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[2]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[2]
Thioredoxin	OT6XU6VW	THIO_HUMAN	Gene/Protein Processing	[3]
X-box-binding protein 1	OTJYCREE	XBP1_HUMAN	Drug Response	[4]

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